SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lkx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 3lkx NASCENT
POLYPEPTIDE-ASSOCIAT
ED COMPLEX SUBUNIT
ALPHA
TRANSCRIPTION FACTOR
BTF3
(Homo
sapiens) 		4 / 8 LEU B  44
ILE B  43
GLY A  30
ILE A  31
 None
 0.85A 3wxoA-3lkxB:
undetectable		 3wxoA-3lkxB:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 3lkx TRANSCRIPTION FACTOR
BTF3
NASCENT
POLYPEPTIDE-ASSOCIAT
ED COMPLEX SUBUNIT
ALPHA
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU A  82
GLY A  83
ASP A  85
THR B  33
THR B  36
 None
 1.11A 4o5fA-3lkxA:
undetectable
4o5fB-3lkxA:
undetectable		 4o5fA-3lkxA:
14.46
4o5fB-3lkxA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3lkx TRANSCRIPTION FACTOR
BTF3
NASCENT
POLYPEPTIDE-ASSOCIAT
ED COMPLEX SUBUNIT
ALPHA
(Homo
sapiens;
Homo
sapiens) 		5 / 12 THR B  36
LEU A  82
GLY A  83
ASP A  85
THR B  33
 None
 1.13A 4o5fA-3lkxB:
undetectable
4o5fB-3lkxB:
undetectable		 4o5fA-3lkxB:
12.62
4o5fB-3lkxB:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 3lkx NASCENT
POLYPEPTIDE-ASSOCIAT
ED COMPLEX SUBUNIT
ALPHA
(Homo
sapiens) 		3 / 3 VAL B  46
THR B  48
ARG B  34
 None
 0.71A 5b2sB-3lkxB:
undetectable		 5b2sB-3lkxB:
2.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 3lkx NASCENT
POLYPEPTIDE-ASSOCIAT
ED COMPLEX SUBUNIT
ALPHA
(Homo
sapiens) 		3 / 3 VAL B  46
THR B  48
ARG B  34
 None
 0.74A 5b2tB-3lkxB:
undetectable		 5b2tB-3lkxB:
2.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 3lkx TRANSCRIPTION FACTOR
BTF3
NASCENT
POLYPEPTIDE-ASSOCIAT
ED COMPLEX SUBUNIT
ALPHA
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU A  82
GLY A  83
ASP A  85
THR B  33
THR B  36
 None
 1.17A 5b8hA-3lkxA:
undetectable
5b8hB-3lkxA:
undetectable		 5b8hA-3lkxA:
12.45
5b8hB-3lkxA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3lkx TRANSCRIPTION FACTOR
BTF3
NASCENT
POLYPEPTIDE-ASSOCIAT
ED COMPLEX SUBUNIT
ALPHA
(Homo
sapiens;
Homo
sapiens) 		5 / 12 THR B  36
LEU A  82
GLY A  83
ASP A  85
THR B  33
 None
 1.15A 5b8hA-3lkxB:
undetectable
5b8hB-3lkxB:
undetectable		 5b8hA-3lkxB:
9.93
5b8hB-3lkxB:
9.93