SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ll3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		5 / 12 GLY A 261
VAL A 257
LEU A 255
LEU A 385
PHE A 279
 None
None
None
None
XUL  A7778 (-4.5A)
 1.31A 1mx1E-3ll3A:
undetectable		 1mx1E-3ll3A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		5 / 12 LEU A 378
ILE A 374
ILE A 371
ARG A 368
LEU A 255
 None
 1.03A 1xdkB-3ll3A:
undetectable		 1xdkB-3ll3A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		5 / 9 LEU A 289
ARG A 264
HIS A  79
ARG A 342
ALA A 343
 None
XUL  A7778 ( 4.7A)
XUL  A7778 (-4.0A)
XUL  A7778 ( 3.1A)
None
 1.44A 2bxcB-3ll3A:
undetectable		 2bxcB-3ll3A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		4 / 7 SER A 241
ASP A 237
SER A 427
GLN A 425
 None
XUL  A7778 (-2.9A)
None
None
 1.07A 2cmlA-3ll3A:
undetectable		 2cmlA-3ll3A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		4 / 8 SER A 241
ASP A 237
SER A 427
GLN A 425
 None
XUL  A7778 (-2.9A)
None
None
 1.01A 2cmlB-3ll3A:
undetectable		 2cmlB-3ll3A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		4 / 8 SER A 241
ASP A 237
SER A 427
GLN A 425
 None
XUL  A7778 (-2.9A)
None
None
 1.06A 2cmlD-3ll3A:
undetectable		 2cmlD-3ll3A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		5 / 11 PHE A  59
GLY A 224
ILE A 225
ILE A 215
LEU A 163
 None
 0.98A 2kawA-3ll3A:
undetectable		 2kawA-3ll3A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		3 / 3 ARG A 305
GLU A 313
GLN A 306
 None
 0.97A 2p16A-3ll3A:
undetectable		 2p16A-3ll3A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		4 / 5 LEU A 440
ARG A 437
ALA A 439
ILE A   4
 None
 0.88A 2qhfA-3ll3A:
undetectable		 2qhfA-3ll3A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		5 / 9 THR A 177
LEU A 289
ARG A 264
SER A 241
GLY A 154
 None
None
XUL  A7778 ( 4.7A)
None
None
 1.16A 3cv9A-3ll3A:
undetectable		 3cv9A-3ll3A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		4 / 7 THR A  11
ILE A  50
ILE A 155
SER A  80
 None
 0.78A 3deuA-3ll3A:
2.4		 3deuA-3ll3A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB800_0
(GLUTAMATE RECEPTOR 2)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		5 / 10 TYR A  19
SER A  75
SER A 427
LEU A 430
GLY A 238
 None
None
None
None
XUL  A7778 ( 4.9A)
 1.40A 3lsfB-3ll3A:
0.0
3lsfE-3ll3A:
undetectable		 3lsfB-3ll3A:
19.00
3lsfE-3ll3A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		4 / 8 LEU A 446
ALA A 439
THR A 209
GLY A 244
 None
 0.91A 3ny4A-3ll3A:
undetectable		 3ny4A-3ll3A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		4 / 5 PHE A 334
ILE A 414
ASN A 302
PHE A 376
 None
None
ATP  A1760 (-4.6A)
None
 1.26A 3octA-3ll3A:
undetectable		 3octA-3ll3A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_B_KKKB413_1
(FLAVOHEMOGLOBIN)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		5 / 12 ILE A 272
GLN A 117
LEU A 182
HIS A  79
ILE A 194
 None
None
None
XUL  A7778 (-4.0A)
None
 1.12A 3ozwB-3ll3A:
undetectable		 3ozwB-3ll3A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		5 / 9 ILE A  65
LEU A  18
ILE A   5
ILE A   4
ILE A  72
 None
 1.00A 3zosA-3ll3A:
undetectable		 3zosA-3ll3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		5 / 11 LEU A 378
GLY A 297
VAL A 407
LEU A 402
GLY A 258
 None
None
None
None
ATP  A1760 (-3.1A)
 0.96A 3zosA-3ll3A:
undetectable
3zosB-3ll3A:
undetectable		 3zosA-3ll3A:
21.05
3zosB-3ll3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		4 / 6 THR A 242
GLY A 244
ILE A 449
LEU A 240
 None
 0.96A 4acbC-3ll3A:
2.0		 4acbC-3ll3A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		3 / 3 TYR A 133
GLN A 107
TRP A 137
 None
 1.18A 4kn2C-3ll3A:
undetectable		 4kn2C-3ll3A:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		5 / 12 CYH A 280
GLY A 291
GLY A 292
GLY A 123
LEU A 182
 None
 1.29A 4n48A-3ll3A:
undetectable		 4n48A-3ll3A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		5 / 12 ASN A 377
ALA A 350
GLY A 340
GLY A 339
GLY A 488
 None
None
DXP  A3264 ( 4.5A)
None
None
 1.01A 4obwB-3ll3A:
undetectable		 4obwB-3ll3A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		3 / 3 SER A 404
ASP A 310
ASP A 320
 ATP  A1760 ( 4.7A)
None
None
 0.53A 4uckA-3ll3A:
undetectable		 4uckA-3ll3A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		4 / 8 TYR A 476
GLY A 373
ILE A 299
SER A 260
 None
 0.71A 5alcL-3ll3A:
undetectable		 5alcL-3ll3A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ENT_C_MIYC901_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT
ACRB,MULTIDRUG
EFFLUX PUMP SUBUNIT
ACRB)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		5 / 9 SER A 427
GLY A 261
SER A 260
ILE A 263
ALA A 381
 None
 1.19A 5entC-3ll3A:
undetectable		 5entC-3ll3A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		3 / 3 ALA A 381
ASN A 384
LEU A 385
 None
 0.22A 5i1nB-3ll3A:
undetectable		 5i1nB-3ll3A:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		3 / 3 ALA A 381
ASN A 384
LEU A 385
 None
 0.29A 5i1oA-3ll3A:
undetectable		 5i1oA-3ll3A:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		3 / 3 ALA A 381
ASN A 384
LEU A 385
 None
 0.44A 5i1pD-3ll3A:
undetectable		 5i1pD-3ll3A:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		4 / 8 ALA A 235
SER A 427
THR A 429
GLY A 238
 None
None
None
XUL  A7778 ( 4.9A)
 1.01A 5v0vA-3ll3A:
undetectable		 5v0vA-3ll3A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_A_9KLA402_0
(EST-Y29)		 3ll3 GLUCONATE KINASE
(Lactobacillus
acidophilus) 		5 / 12 ILE A 248
LEU A 446
GLY A 428
ALA A 431
LEU A 435
 None
 1.06A 5zwrA-3ll3A:
undetectable		 5zwrA-3ll3A:
22.76