SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ll5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 10 ARG A  18
VAL A  84
ILE A   6
GLY A   7
GLY A   8
 None
None
None
ADP  A 246 (-3.2A)
IPE  A 247 ( 3.5A)
 1.02A 1k6cA-3ll5A:
undetectable		 1k6cA-3ll5A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 9 LEU A 162
VAL A  10
GLY A   7
VAL A  84
ILE A  25
 None
None
ADP  A 246 (-3.2A)
None
None
 1.38A 2a1oB-3ll5A:
undetectable		 2a1oB-3ll5A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 6 VAL A 210
LYS A 211
ILE A 244
ILE A 168
 None
None
None
ADP  A 246 ( 4.6A)
 0.89A 2piwA-3ll5A:
undetectable		 2piwA-3ll5A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 ARG A  18
VAL A  84
ILE A   6
GLY A   7
GLY A   8
 None
None
None
ADP  A 246 (-3.2A)
IPE  A 247 ( 3.5A)
 1.04A 2r5pA-3ll5A:
undetectable		 2r5pA-3ll5A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 ARG A  18
VAL A  84
ILE A   6
GLY A   7
GLY A   8
 None
None
None
ADP  A 246 (-3.2A)
IPE  A 247 ( 3.5A)
 1.04A 2r5pC-3ll5A:
undetectable		 2r5pC-3ll5A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 5 ARG A  26
ALA A  87
ASP A  86
GLU A  90
 None
 1.41A 2xrzA-3ll5A:
3.1		 2xrzA-3ll5A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DHIC32_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 6 GLY A 143
GLY A  44
GLY A  45
GLY A 128
GLY A  49
 IPE  A 247 (-3.3A)
IPE  A 247 (-3.3A)
IPE  A 247 (-3.8A)
IPE  A 247 (-3.5A)
IPE  A 247 (-3.3A)
 1.47A 3bogA-3ll5A:
undetectable
3bogC-3ll5A:
undetectable		 3bogA-3ll5A:
undetectable
3bogC-3ll5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)		 3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 8 GLY A  44
GLY A  45
GLY A  49
HIS A  50
 IPE  A 247 (-3.3A)
IPE  A 247 (-3.8A)
IPE  A 247 (-3.3A)
IPE  A 247 (-4.1A)
 0.39A 3d41A-3ll5A:
23.2		 3d41A-3ll5A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)		 3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 10 TYR A 111
ASP A 149
LEU A 103
VAL A  98
ILE A   3
 None
 1.31A 3kz7A-3ll5A:
undetectable		 3kz7A-3ll5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 9 VAL A  31
VAL A  41
ILE A   6
GLY A 225
ALA A  24
 None
 1.04A 4fwdA-3ll5A:
undetectable		 4fwdA-3ll5A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 11 VAL A 123
VAL A 125
ILE A  28
ILE A   6
LEU A  38
 None
 1.07A 5e4dB-3ll5A:
undetectable		 5e4dB-3ll5A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 6 ILE A  96
ILE A   3
LEU A  38
PHE A 161
 None
 1.01A 5vkqB-3ll5A:
undetectable
5vkqC-3ll5A:
undetectable		 5vkqB-3ll5A:
9.18
5vkqC-3ll5A:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		4 / 6 ILE A  96
ILE A   3
LEU A  38
PHE A 161
 None
 1.04A 5vkqC-3ll5A:
undetectable
5vkqD-3ll5A:
undetectable		 5vkqC-3ll5A:
9.18
5vkqD-3ll5A:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 3ll5 GAMMA-GLUTAMYL
KINASE RELATED
PROTEIN
(Thermoplasma
acidophilum) 		5 / 12 LYS A 213
VAL A 210
ILE A 244
ASN A 188
ILE A 185
 None
 1.45A 6gsdA-3ll5A:
2.7		 6gsdA-3ll5A:
15.10