SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ll8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		3 / 3 ASP A 118
HIS A 151
HIS A  92
 ZN  A 505 (-2.7A)
PO4  A 500 (-3.8A)
FE  A 506 ( 3.3A)
 0.63A 1oe1A-3ll8A:
undetectable		 1oe1A-3ll8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		3 / 3 ASP A 118
HIS A 151
HIS A  92
 ZN  A 505 (-2.7A)
PO4  A 500 (-3.8A)
FE  A 506 ( 3.3A)
 0.62A 1oe3A-3ll8A:
undetectable		 1oe3A-3ll8A:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TCO_C_FK5C509_1
(SERINE/THREONINE
PHOSPHATASE B2
FK506-BINDING
PROTEIN)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 4 TRP A 352
SER A 353
PHE A 356
GLU A 359
 None
 0.63A 1tcoA-3ll8A:
57.4		 1tcoA-3ll8A:
99.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		5 / 10 LEU A 139
ALA A 135
ILE A 138
VAL A  34
ALA A  31
 None
 1.16A 1xp0A-3ll8A:
undetectable		 1xp0A-3ll8A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 6 TYR A 291
GLY A  89
PHE A 306
SER A 307
 None
 1.28A 2a3cA-3ll8A:
undetectable		 2a3cA-3ll8A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 6 TYR A 291
GLY A  89
PHE A 306
SER A 307
 None
 1.31A 2a3cB-3ll8A:
undetectable		 2a3cB-3ll8A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3ll8 CALCINEURIN SUBUNIT
B TYPE 1
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 8 PHE A  96
PHE A 125
GLU A  53
GLN B 130
 None
 1.33A 2aoxA-3ll8A:
undetectable		 2aoxA-3ll8A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_B_THAB401_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3ll8 CALCINEURIN SUBUNIT
B TYPE 1
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 7 PHE A  96
PHE A 125
GLU A  53
GLN B 130
 None
 1.32A 2aoxB-3ll8A:
0.5		 2aoxB-3ll8A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		5 / 12 GLY A 117
GLY A 149
GLY A 200
VAL A 120
ILE A  91
 None
 1.02A 2b25A-3ll8A:
undetectable		 2b25A-3ll8A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 8 ARG A 254
HIS A 199
ASP A 118
ARG A 122
 PO4  A 500 (-3.1A)
ZN  A 505 (-3.3A)
ZN  A 505 (-2.7A)
PO4  A 500 (-2.9A)
 1.36A 2rk8A-3ll8A:
undetectable		 2rk8A-3ll8A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 7 ARG A 254
HIS A 199
ASP A 118
ARG A 122
 PO4  A 500 (-3.1A)
ZN  A 505 (-3.3A)
ZN  A 505 (-2.7A)
PO4  A 500 (-2.9A)
 1.31A 2rk8B-3ll8A:
undetectable		 2rk8B-3ll8A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		3 / 3 ASP A 118
HIS A 151
HIS A  92
 ZN  A 505 (-2.7A)
PO4  A 500 (-3.8A)
FE  A 506 ( 3.3A)
 0.65A 2xxgA-3ll8A:
undetectable		 2xxgA-3ll8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		3 / 3 ASP A 118
HIS A 151
HIS A  92
 ZN  A 505 (-2.7A)
PO4  A 500 (-3.8A)
FE  A 506 ( 3.3A)
 0.66A 2xxgC-3ll8A:
undetectable		 2xxgC-3ll8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 5 LEU A 274
GLN A 193
THR A 208
HIS A 271
 None
 1.36A 2zj0C-3ll8A:
undetectable		 2zj0C-3ll8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		5 / 12 ILE A 206
SER A 257
GLY A 200
ASP A 234
ASN A 272
 None
 1.24A 2zw9A-3ll8A:
undetectable		 2zw9A-3ll8A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_B_ADNB500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 5 LEU A 274
GLN A 193
THR A 208
HIS A 271
 None
 1.34A 3ce6B-3ll8A:
undetectable		 3ce6B-3ll8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		5 / 12 TYR A 113
CYH A  88
ILE A 305
VAL A 104
GLY A 106
 None
 1.06A 3em0B-3ll8A:
undetectable		 3em0B-3ll8A:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6G_A_IZPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		5 / 12 PHE A 162
ILE A  65
VAL A 174
CYH A 178
TYR A 170
 None
 1.34A 3p6gA-3ll8A:
undetectable		 3p6gA-3ll8A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		5 / 12 ASP A  90
LEU A 302
ASN A 150
THR A 304
GLY A 149
 FE  A 506 (-3.1A)
None
PO4  A 500 ( 2.4A)
None
None
 1.12A 3vaqB-3ll8A:
undetectable		 3vaqB-3ll8A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		5 / 12 CYH A  88
SER A 307
HIS A  92
LEU A  98
LEU A 144
 None
None
FE  A 506 ( 3.3A)
None
None
 1.32A 3vn2A-3ll8A:
undetectable		 3vn2A-3ll8A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
CALCINEURIN SUBUNIT
B TYPE 1
(Homo
sapiens;
Homo
sapiens) 		5 / 11 LEU B 115
VAL B 114
ALA B  94
SER A 353
PHE A 350
 None
 1.39A 4evrA-3ll8B:
undetectable		 4evrA-3ll8B:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 7 ASP A 121
ASP A 118
ASN A 150
GLU A 152
 None
ZN  A 505 (-2.7A)
PO4  A 500 ( 2.4A)
None
 1.18A 4feuB-3ll8A:
undetectable		 4feuB-3ll8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 8 ASP A 121
ASP A 118
ASN A 150
GLU A 152
 None
ZN  A 505 (-2.7A)
PO4  A 500 ( 2.4A)
None
 1.21A 4feuF-3ll8A:
undetectable		 4feuF-3ll8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 7 ASP A 121
ASP A 118
ASN A 150
GLU A 152
 None
ZN  A 505 (-2.7A)
PO4  A 500 ( 2.4A)
None
 1.21A 4fevD-3ll8A:
undetectable		 4fevD-3ll8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 7 ASP A 121
ASP A 118
ASN A 150
GLU A 152
 None
ZN  A 505 (-2.7A)
PO4  A 500 ( 2.4A)
None
 1.19A 4fevF-3ll8A:
undetectable		 4fevF-3ll8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 8 ASP A 121
ASP A 118
ASN A 150
GLU A 152
 None
ZN  A 505 (-2.7A)
PO4  A 500 ( 2.4A)
None
 1.20A 4fewD-3ll8A:
undetectable		 4fewD-3ll8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 8 ASP A 121
ASP A 118
ASN A 150
GLU A 152
 None
ZN  A 505 (-2.7A)
PO4  A 500 ( 2.4A)
None
 1.19A 4fewF-3ll8A:
undetectable		 4fewF-3ll8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 7 ASP A 121
ASP A 118
ASN A 150
GLU A 152
 None
ZN  A 505 (-2.7A)
PO4  A 500 ( 2.4A)
None
 1.20A 4fexB-3ll8A:
undetectable		 4fexB-3ll8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 8 ASP A 121
ASP A 118
ASN A 150
GLU A 152
 None
ZN  A 505 (-2.7A)
PO4  A 500 ( 2.4A)
None
 1.21A 4gkhB-3ll8A:
undetectable		 4gkhB-3ll8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 7 ASP A 121
ASP A 118
ASN A 150
GLU A 152
 None
ZN  A 505 (-2.7A)
PO4  A 500 ( 2.4A)
None
 1.18A 4gkhG-3ll8A:
undetectable		 4gkhG-3ll8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 8 ASP A 121
ASP A 118
ASN A 150
GLU A 152
 None
ZN  A 505 (-2.7A)
PO4  A 500 ( 2.4A)
None
 1.20A 4gkiA-3ll8A:
undetectable		 4gkiA-3ll8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 8 ASP A 121
ASP A 118
ASN A 150
GLU A 152
 None
ZN  A 505 (-2.7A)
PO4  A 500 ( 2.4A)
None
 1.18A 4gkiC-3ll8A:
undetectable		 4gkiC-3ll8A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		5 / 12 ALA A 177
PHE A 182
ALA A  69
VAL A 120
CYH A 166
 None
 1.09A 4k6iA-3ll8A:
undetectable		 4k6iA-3ll8A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KUK_A_RBFA201_2
(BLUE-LIGHT
PHOTORECEPTOR)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		5 / 9 MET A 191
ILE A 305
ARG A 279
LEU A 116
ILE A 331
 None
 0.83A 4kukA-3ll8A:
undetectable		 4kukA-3ll8A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 3ll8 CALCINEURIN SUBUNIT
B TYPE 1
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		5 / 12 GLY B  77
GLN B  80
VAL B  57
LEU A 365
PHE B  93
 None
 1.24A 4pd5A-3ll8B:
undetectable		 4pd5A-3ll8B:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD9_A_ADNA501_1
(NUPC FAMILY PROTEIN)		 3ll8 CALCINEURIN SUBUNIT
B TYPE 1
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		5 / 12 GLY B  77
GLN B  80
VAL B  57
LEU A 365
PHE B  93
 None
 1.26A 4pd9A-3ll8B:
undetectable		 4pd9A-3ll8B:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 6 TYR A 140
TYR A 132
LEU A 133
PHE A 102
 None
 1.07A 4twdB-3ll8A:
undetectable
4twdC-3ll8A:
undetectable		 4twdB-3ll8A:
22.55
4twdC-3ll8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 6 TYR A 140
TYR A 132
LEU A 133
PHE A 102
 None
 1.02A 4twdD-3ll8A:
undetectable
4twdE-3ll8A:
undetectable		 4twdD-3ll8A:
22.55
4twdE-3ll8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 7 TYR A 132
LEU A 133
PHE A 102
TYR A 140
 None
 1.15A 4twdF-3ll8A:
undetectable
4twdJ-3ll8A:
undetectable		 4twdF-3ll8A:
22.55
4twdJ-3ll8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 6 TYR A 140
TYR A 132
LEU A 133
PHE A 102
 None
 1.10A 4twdF-3ll8A:
undetectable
4twdG-3ll8A:
undetectable		 4twdF-3ll8A:
22.55
4twdG-3ll8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 6 TYR A 140
TYR A 132
LEU A 133
PHE A 102
 None
 1.15A 4twdI-3ll8A:
undetectable
4twdJ-3ll8A:
undetectable		 4twdI-3ll8A:
22.55
4twdJ-3ll8A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		6 / 12 LEU A 209
LEU A  78
ILE A 212
ILE A 230
VAL A 198
LEU A 274
 None
 1.34A 4y0sA-3ll8A:
undetectable		 4y0sA-3ll8A:
18.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		5 / 6 LEU A 343
TRP A 352
SER A 353
PHE A 356
GLU A 359
 None
 0.83A 5b8iA-3ll8A:
56.7		 5b8iA-3ll8A:
73.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		5 / 6 LEU A 343
TRP A 352
SER A 353
PRO A 355
PHE A 356
 None
 0.52A 5b8iA-3ll8A:
56.7		 5b8iA-3ll8A:
73.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5B8I_C_FK5C201_2
(CALCINEURIN SUBUNIT
B, VARIANT
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3ll8 CALCINEURIN SUBUNIT
B TYPE 1
(Homo
sapiens) 		4 / 4 LEU B 115
MET B 118
VAL B 119
ASN B 122
 None
 0.37A 5b8iB-3ll8B:
22.4		 5b8iB-3ll8B:
63.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 6 CYH A 197
LEU A 114
HIS A 199
LEU A 147
 None
None
ZN  A 505 (-3.3A)
None
 1.19A 5hpuC-3ll8A:
undetectable
5hpuD-3ll8A:
undetectable		 5hpuC-3ll8A:
5.42
5hpuD-3ll8A:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3ll8 CALCINEURIN SUBUNIT
B TYPE 1
(Homo
sapiens) 		4 / 6 PHE B 152
VAL B 156
MET B 165
ILE B 161
 None
 1.15A 5iwuA-3ll8B:
undetectable		 5iwuA-3ll8B:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		4 / 4 ASP A 118
HIS A 199
HIS A 281
HIS A 151
 ZN  A 505 (-2.7A)
ZN  A 505 (-3.3A)
ZN  A 505 ( 3.3A)
PO4  A 500 (-3.8A)
 1.49A 5ncdD-3ll8A:
undetectable		 5ncdD-3ll8A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		5 / 12 LEU A 209
THR A 208
ILE A 212
LEU A 274
LEU A 269
 None
 1.01A 5nfjA-3ll8A:
undetectable		 5nfjA-3ll8A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens) 		5 / 12 LEU A 136
LEU A  98
PHE A 115
THR A  86
VAL A 321
 None
 1.21A 6debB-3ll8A:
undetectable		 6debB-3ll8A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3ll8 CALCINEURIN SUBUNIT
B TYPE 1
(Homo
sapiens) 		4 / 6 LYS B  28
PHE B  71
LEU B  37
PHE B  42
 None
 1.26A 6nmpC-3ll8B:
undetectable
6nmpJ-3ll8B:
undetectable		 6nmpC-3ll8B:
18.65
6nmpJ-3ll8B:
17.33