SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3llm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_A_GW6A1_1
(GLUCOCORTICOID
RECEPTOR)		 3llm ATP-DEPENDENT RNA
HELICASE A
(Homo
sapiens) 		5 / 12 GLY A 462
GLN A 371
LEU A 368
LEU A 426
THR A 419
 None
None
None
None
ADP  A 565 (-2.8A)
 1.44A 3cldA-3llmA:
0.0		 3cldA-3llmA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_C_H4BC600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 3llm ATP-DEPENDENT RNA
HELICASE A
(Homo
sapiens) 		4 / 8 ARG A 434
ILE A 401
PHE A 429
GLU A 394
 None
 1.15A 4cx7C-3llmA:
undetectable
4cx7D-3llmA:
undetectable		 4cx7C-3llmA:
22.47
4cx7D-3llmA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 3llm ATP-DEPENDENT RNA
HELICASE A
(Homo
sapiens) 		5 / 9 VAL A 457
ALA A 458
PHE A 488
SER A 485
GLY A 470
 None
 1.30A 4mmeB-3llmA:
undetectable		 4mmeB-3llmA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 3llm ATP-DEPENDENT RNA
HELICASE A
(Homo
sapiens) 		5 / 10 ALA A 454
VAL A 457
PHE A 488
SER A 485
GLY A 470
 None
 1.22A 4xp1A-3llmA:
undetectable		 4xp1A-3llmA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 3llm ATP-DEPENDENT RNA
HELICASE A
(Homo
sapiens) 		3 / 3 VAL A 563
GLN A 420
CYH A 415
 None
None
ADP  A 565 (-4.8A)
 0.60A 5icxA-3llmA:
undetectable
5icxE-3llmA:
undetectable		 5icxA-3llmA:
22.04
5icxE-3llmA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 3llm ATP-DEPENDENT RNA
HELICASE A
(Homo
sapiens) 		3 / 3 VAL A 563
GLN A 420
CYH A 415
 None
None
ADP  A 565 (-4.8A)
 0.89A 5icxC-3llmA:
undetectable
5icxF-3llmA:
undetectable		 5icxC-3llmA:
22.04
5icxF-3llmA:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3llm ATP-DEPENDENT RNA
HELICASE A
(Homo
sapiens) 		3 / 3 GLU A 553
TYR A 554
ARG A 528
 None
 0.74A 5uunA-3llmA:
undetectable		 5uunA-3llmA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3llm ATP-DEPENDENT RNA
HELICASE A
(Homo
sapiens) 		3 / 3 GLU A 553
TYR A 554
ARG A 528
 None
 0.58A 5uunB-3llmA:
undetectable		 5uunB-3llmA:
21.59