SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3llt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 6 TRP A 751
VAL A 745
ALA A 742
SER A 759
 None
 0.92A 1p6kA-3lltA:
undetectable		 1p6kA-3lltA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.44A 1p6kA-3lltA:
undetectable
1p6kB-3lltA:
undetectable		 1p6kA-3lltA:
21.74
1p6kB-3lltA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.45A 1p6kA-3lltA:
undetectable
1p6kB-3lltA:
undetectable		 1p6kA-3lltA:
21.74
1p6kB-3lltA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		8 / 12 VAL A 566
ALA A 579
LYS A 581
GLU A 596
LEU A 600
GLY A 634
LEU A 684
ASP A 720
 ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
None
None
ANP  A 877 (-2.9A)
 0.96A 1t46A-3lltA:
21.3		 1t46A-3lltA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		8 / 12 VAL A 566
ALA A 579
LYS A 581
GLU A 596
LEU A 600
VAL A 614
GLY A 634
ASP A 720
 ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
None
None
ANP  A 877 (-2.9A)
 0.79A 1t46A-3lltA:
21.3		 1t46A-3lltA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 ASN A 682
HIS A 675
PHE A 721
ILE A 661
 ANP  A 877 ( 4.8A)
None
None
None
 1.27A 1tdnA-3lltA:
undetectable		 1tdnA-3lltA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		5 / 12 LEU A 678
PRO A 680
ILE A 661
LEU A 764
GLY A 761
 None
 0.88A 1uakA-3lltA:
undetectable		 1uakA-3lltA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		5 / 12 ALA A 579
GLU A 596
LEU A 600
LEU A 668
HIS A 675
 ANP  A 877 ( 3.7A)
ANP  A 877 ( 4.4A)
None
None
None
 0.66A 1uwhA-3lltA:
21.3		 1uwhA-3lltA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		6 / 12 ALA A 579
LYS A 581
GLU A 596
LEU A 600
LEU A 668
HIS A 675
 ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
None
None
 0.71A 1uwhB-3lltA:
21.2		 1uwhB-3lltA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 LYS A 581
LEU A 600
ILE A 613
ASP A 720
 ANP  A 877 (-2.7A)
None
None
ANP  A 877 (-2.9A)
 0.75A 1uwjA-3lltA:
7.2		 1uwjA-3lltA:
26.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		7 / 12 VAL A 566
LYS A 581
VAL A 614
PHE A 630
ASN A 682
LEU A 684
ASP A 720
 ANP  A 877 (-4.1A)
ANP  A 877 (-2.7A)
None
None
ANP  A 877 ( 4.8A)
None
ANP  A 877 (-2.9A)
 0.88A 2eufB-3lltA:
29.2		 2eufB-3lltA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		7 / 12 VAL A 566
ALA A 579
GLU A 596
ILE A 603
VAL A 614
GLY A 634
LEU A 684
 ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 ( 4.4A)
None
None
None
None
 1.05A 2hyyC-3lltA:
21.4		 2hyyC-3lltA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		5 / 12 LEU A 600
ILE A 613
ALA A 724
PHE A 721
LEU A 668
 None
 1.16A 2qb4A-3lltA:
undetectable		 2qb4A-3lltA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 ASP A 752
SER A 754
SER A 864
GLU A 867
 None
 1.18A 3bc9A-3lltA:
undetectable		 3bc9A-3lltA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EYG_A_MI1A1_1
(TYROSINE-PROTEIN
KINASE)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		9 / 12 GLY A 559
GLY A 561
GLY A 564
VAL A 566
ALA A 579
LYS A 581
SER A 636
ASN A 682
LEU A 684
 ANP  A 877 (-3.8A)
ANP  A 877 (-3.3A)
ANP  A 877 (-3.9A)
ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
None
ANP  A 877 ( 4.8A)
None
 0.89A 3eygA-3lltA:
8.9		 3eygA-3lltA:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		6 / 12 VAL A 566
ALA A 579
GLU A 596
LEU A 600
HIS A 675
ASP A 720
 ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 ( 4.4A)
None
None
ANP  A 877 (-2.9A)
 1.08A 3gp0A-3lltA:
24.7		 3gp0A-3lltA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGG_A_CHDA211_0
(CMER)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 CYH A 723
SER A 592
TYR A 589
LYS A 581
 None
None
None
ANP  A 877 (-2.7A)
 1.47A 3hggA-3lltA:
undetectable		 3hggA-3lltA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 8 ALA A 579
LYS A 581
GLU A 596
LEU A 628
 ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
 0.32A 3lfaA-3lltA:
23.4		 3lfaA-3lltA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		6 / 12 GLY A 559
VAL A 566
ALA A 579
LYS A 581
LEU A 600
GLY A 634
 ANP  A 877 (-3.8A)
ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
None
None
 0.61A 3ohtB-3lltA:
5.3		 3ohtB-3lltA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		7 / 12 VAL A 566
ALA A 579
GLU A 596
LEU A 600
PHE A 630
LEU A 668
HIS A 675
 ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 ( 4.4A)
None
None
None
None
 0.77A 3rgfA-3lltA:
11.3		 3rgfA-3lltA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		7 / 12 VAL A 566
ALA A 579
GLU A 596
LEU A 600
PHE A 630
LEU A 673
HIS A 675
 ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 ( 4.4A)
None
None
None
None
 1.19A 3rgfA-3lltA:
11.3		 3rgfA-3lltA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 ASN A 612
ILE A 661
PHE A 760
MET A 757
 None
 1.10A 3tvxB-3lltA:
undetectable		 3tvxB-3lltA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.42A 3ufpA-3lltA:
undetectable
3ufpB-3lltA:
undetectable		 3ufpA-3lltA:
21.60
3ufpB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.44A 3ufrA-3lltA:
undetectable
3ufrB-3lltA:
undetectable		 3ufrA-3lltA:
21.60
3ufrB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFS_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.44A 3ufsA-3lltA:
undetectable
3ufsB-3lltA:
undetectable		 3ufsA-3lltA:
21.60
3ufsB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_1
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		7 / 12 GLY A 561
GLY A 564
VAL A 566
ALA A 579
LYS A 581
VAL A 614
LEU A 684
 ANP  A 877 (-3.3A)
ANP  A 877 (-3.9A)
ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
None
None
 0.94A 3v5wA-3lltA:
8.0		 3v5wA-3lltA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 8 VAL A 566
LYS A 581
PHE A 630
ILE A 719
 ANP  A 877 (-4.1A)
ANP  A 877 (-2.7A)
None
ANP  A 877 ( 4.3A)
 0.52A 3warA-3lltA:
27.5		 3warA-3lltA:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C39_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.42A 4c39A-3lltA:
undetectable
4c39B-3lltA:
undetectable		 4c39A-3lltA:
21.60
4c39B-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C39_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.39A 4c39A-3lltA:
undetectable
4c39B-3lltA:
undetectable		 4c39A-3lltA:
21.60
4c39B-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		7 / 12 ALA A 579
LYS A 581
GLU A 596
LEU A 600
HIS A 675
LEU A 684
ASP A 720
 ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
None
None
ANP  A 877 (-2.9A)
 1.07A 4c8bA-3lltA:
21.0		 4c8bA-3lltA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_B_0LIB1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		8 / 12 ALA A 579
LYS A 581
GLU A 596
LEU A 600
ILE A 613
HIS A 675
LEU A 684
ASP A 720
 ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
None
None
None
ANP  A 877 (-2.9A)
 1.06A 4c8bB-3lltA:
20.8		 4c8bB-3lltA:
28.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.39A 4ctpA-3lltA:
undetectable
4ctpB-3lltA:
undetectable		 4ctpA-3lltA:
21.60
4ctpB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.34A 4ctqA-3lltA:
undetectable
4ctqB-3lltA:
undetectable		 4ctqA-3lltA:
21.60
4ctqB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.37A 4cx6A-3lltA:
undetectable
4cx6B-3lltA:
undetectable		 4cx6A-3lltA:
21.60
4cx6B-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		7 / 12 VAL A 566
ALA A 579
ASP A 677
LYS A 679
ASN A 682
LEU A 684
ILE A 719
 ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 ( 4.9A)
None
ANP  A 877 ( 4.8A)
None
ANP  A 877 ( 4.3A)
 0.63A 4i41A-3lltA:
24.5		 4i41A-3lltA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		6 / 11 VAL A 566
ALA A 579
LYS A 581
LEU A 684
ILE A 719
ASP A 720
 ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
None
ANP  A 877 ( 4.3A)
ANP  A 877 (-2.9A)
 0.80A 4iaaA-3lltA:
24.4		 4iaaA-3lltA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		5 / 12 LEU A 874
LEU A 868
LEU A 764
ILE A 651
LEU A 846
 None
 1.11A 4j24A-3lltA:
undetectable		 4j24A-3lltA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSF_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.39A 4jsfA-3lltA:
undetectable
4jsfB-3lltA:
undetectable		 4jsfA-3lltA:
21.60
4jsfB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSG_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.40A 4jsgA-3lltA:
undetectable
4jsgB-3lltA:
undetectable		 4jsgA-3lltA:
21.38
4jsgB-3lltA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5D_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.43A 4k5dA-3lltA:
undetectable
4k5dB-3lltA:
undetectable		 4k5dA-3lltA:
21.60
4k5dB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K5G_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.40A 4k5gA-3lltA:
undetectable
4k5gB-3lltA:
undetectable		 4k5gA-3lltA:
21.60
4k5gB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUX_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.47A 4luxA-3lltA:
undetectable
4luxB-3lltA:
undetectable		 4luxA-3lltA:
21.60
4luxB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUX_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.42A 4luxA-3lltA:
undetectable
4luxB-3lltA:
undetectable		 4luxA-3lltA:
21.60
4luxB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_1
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		6 / 12 VAL A 566
ALA A 579
LYS A 581
GLU A 596
LEU A 684
ASP A 720
 ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
ANP  A 877 (-2.9A)
 0.75A 4r7iA-3lltA:
20.9		 4r7iA-3lltA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_2
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		7 / 12 ALA A 579
LYS A 581
LEU A 600
GLY A 634
HIS A 675
LEU A 684
ASP A 720
 ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
None
None
None
None
ANP  A 877 (-2.9A)
 1.12A 4u0iA-3lltA:
21.4		 4u0iA-3lltA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGZ_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.36A 4ugzA-3lltA:
undetectable
4ugzB-3lltA:
undetectable		 4ugzA-3lltA:
21.60
4ugzB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.42A 4uh2A-3lltA:
undetectable
4uh2B-3lltA:
undetectable		 4uh2A-3lltA:
21.60
4uh2B-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.37A 4uh3A-3lltA:
undetectable
4uh3B-3lltA:
undetectable		 4uh3A-3lltA:
21.60
4uh3B-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH5_B_H4BB760_1
(NEURONAL NITRIC
OXIDE SYNTHASE)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.35A 4uh5A-3lltA:
undetectable
4uh5B-3lltA:
undetectable		 4uh5A-3lltA:
21.06
4uh5B-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.37A 4uh6A-3lltA:
undetectable
4uh6B-3lltA:
undetectable		 4uh6A-3lltA:
21.06
4uh6B-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.29A 4uh6A-3lltA:
undetectable
4uh6B-3lltA:
undetectable		 4uh6A-3lltA:
21.06
4uh6B-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		5 / 12 ALA A 579
GLU A 596
ILE A 603
LEU A 668
HIS A 675
 ANP  A 877 ( 3.7A)
ANP  A 877 ( 4.4A)
None
None
None
 0.82A 4v01A-3lltA:
20.5		 4v01A-3lltA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3W_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 6 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.39A 4v3wA-3lltA:
undetectable
4v3wB-3lltA:
undetectable		 4v3wA-3lltA:
21.60
4v3wB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		5 / 12 ALA A 579
LYS A 581
LEU A 600
ASP A 720
PHE A 721
 ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
None
ANP  A 877 (-2.9A)
None
 0.97A 4xv2B-3lltA:
21.7		 4xv2B-3lltA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.42A 5ad4A-3lltA:
undetectable
5ad4B-3lltA:
undetectable		 5ad4A-3lltA:
21.60
5ad4B-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.39A 5ad4A-3lltA:
undetectable
5ad4B-3lltA:
undetectable		 5ad4A-3lltA:
21.60
5ad4B-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.32A 5ad5A-3lltA:
undetectable
5ad5B-3lltA:
undetectable		 5ad5A-3lltA:
21.60
5ad5B-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AD6_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.27A 5ad6A-3lltA:
undetectable
5ad6B-3lltA:
undetectable		 5ad6A-3lltA:
21.60
5ad6B-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.34A 5adaA-3lltA:
undetectable
5adaB-3lltA:
undetectable		 5adaA-3lltA:
21.60
5adaB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.38A 5adaA-3lltA:
undetectable
5adaB-3lltA:
undetectable		 5adaA-3lltA:
21.60
5adaB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADG_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.34A 5adgA-3lltA:
undetectable
5adgB-3lltA:
undetectable		 5adgA-3lltA:
21.06
5adgB-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADI_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.34A 5adiA-3lltA:
undetectable
5adiB-3lltA:
undetectable		 5adiA-3lltA:
21.06
5adiB-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		3 / 3 ASN A 736
SER A 759
ARG A 862
 None
 0.90A 5b2qA-3lltA:
undetectable		 5b2qA-3lltA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.42A 5fvqA-3lltA:
undetectable
5fvqB-3lltA:
undetectable		 5fvqA-3lltA:
21.60
5fvqB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVS_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.41A 5fvsA-3lltA:
undetectable
5fvsB-3lltA:
undetectable		 5fvsA-3lltA:
21.60
5fvsB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVT_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.30A 5fvtA-3lltA:
undetectable
5fvtB-3lltA:
undetectable		 5fvtA-3lltA:
21.60
5fvtB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVU_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.37A 5fvuA-3lltA:
undetectable
5fvuB-3lltA:
undetectable		 5fvuA-3lltA:
21.06
5fvuB-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVV_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.41A 5fvvA-3lltA:
undetectable
5fvvB-3lltA:
undetectable		 5fvvA-3lltA:
21.06
5fvvB-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVV_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.41A 5fvvA-3lltA:
undetectable
5fvvB-3lltA:
undetectable		 5fvvA-3lltA:
21.06
5fvvB-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.34A 5fvwA-3lltA:
undetectable
5fvwB-3lltA:
undetectable		 5fvwA-3lltA:
21.06
5fvwB-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVW_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.38A 5fvwA-3lltA:
undetectable
5fvwB-3lltA:
undetectable		 5fvwA-3lltA:
21.06
5fvwB-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVX_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.35A 5fvxA-3lltA:
undetectable
5fvxB-3lltA:
undetectable		 5fvxA-3lltA:
21.06
5fvxB-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FW0_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.28A 5fw0A-3lltA:
undetectable
5fw0B-3lltA:
undetectable		 5fw0A-3lltA:
21.60
5fw0B-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0N_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.41A 5g0nA-3lltA:
undetectable
5g0nB-3lltA:
undetectable		 5g0nA-3lltA:
21.60
5g0nB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0N_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.32A 5g0nA-3lltA:
undetectable
5g0nB-3lltA:
undetectable		 5g0nA-3lltA:
21.60
5g0nB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		6 / 12 ALA A 579
LYS A 581
GLU A 596
LEU A 600
LEU A 668
HIS A 675
 ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
None
None
 0.74A 5hi2A-3lltA:
21.5		 5hi2A-3lltA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		7 / 12 GLY A 559
VAL A 566
ALA A 579
LYS A 581
GLU A 596
GLY A 634
ILE A 719
 ANP  A 877 (-3.8A)
ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
ANP  A 877 ( 4.3A)
 0.82A 5mafA-3lltA:
25.1		 5mafA-3lltA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_1
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		6 / 12 LEU A 568
ALA A 579
GLU A 596
VAL A 614
GLY A 634
LEU A 684
 None
ANP  A 877 ( 3.7A)
ANP  A 877 ( 4.4A)
None
None
None
 0.85A 5te0A-3lltA:
24.0		 5te0A-3lltA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.45A 5untA-3lltA:
undetectable
5untB-3lltA:
undetectable		 5untA-3lltA:
21.60
5untB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNT_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.31A 5untA-3lltA:
undetectable
5untB-3lltA:
undetectable		 5untA-3lltA:
21.60
5untB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.39A 5unuA-3lltA:
undetectable
5unuB-3lltA:
undetectable		 5unuA-3lltA:
21.60
5unuB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNU_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.30A 5unuA-3lltA:
undetectable
5unuB-3lltA:
undetectable		 5unuA-3lltA:
21.60
5unuB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.39A 5unwA-3lltA:
undetectable
5unwB-3lltA:
undetectable		 5unwA-3lltA:
21.60
5unwB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.41A 5unyA-3lltA:
undetectable
5unyB-3lltA:
undetectable		 5unyA-3lltA:
21.60
5unyB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.42A 5unyA-3lltA:
undetectable
5unyB-3lltA:
undetectable		 5unyA-3lltA:
21.60
5unyB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.44A 5unzA-3lltA:
undetectable
5unzB-3lltA:
undetectable		 5unzA-3lltA:
21.60
5unzB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.39A 5uo1A-3lltA:
undetectable
5uo1B-3lltA:
undetectable		 5uo1A-3lltA:
21.06
5uo1B-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.32A 5uo1A-3lltA:
undetectable
5uo1B-3lltA:
undetectable		 5uo1A-3lltA:
21.06
5uo1B-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.32A 5uo3A-3lltA:
undetectable
5uo3B-3lltA:
undetectable		 5uo3A-3lltA:
21.06
5uo3B-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO3_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.31A 5uo3A-3lltA:
undetectable
5uo3B-3lltA:
undetectable		 5uo3A-3lltA:
21.06
5uo3B-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.33A 5uo4A-3lltA:
undetectable
5uo4B-3lltA:
undetectable		 5uo4A-3lltA:
21.06
5uo4B-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO5_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.32A 5uo5A-3lltA:
undetectable
5uo5B-3lltA:
undetectable		 5uo5A-3lltA:
21.06
5uo5B-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO6_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.33A 5uo6A-3lltA:
undetectable
5uo6B-3lltA:
undetectable		 5uo6A-3lltA:
21.06
5uo6B-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 8 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.31A 5uo7A-3lltA:
undetectable
5uo7B-3lltA:
undetectable		 5uo7A-3lltA:
21.06
5uo7B-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.29A 5uo7A-3lltA:
undetectable
5uo7B-3lltA:
undetectable		 5uo7A-3lltA:
21.06
5uo7B-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		6 / 12 ALA A 579
LYS A 581
GLU A 596
LEU A 628
GLY A 634
PRO A 635
 ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
None
None
 0.60A 5vcvA-3lltA:
25.9		 5vcvA-3lltA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		6 / 12 VAL A 566
ALA A 579
GLU A 596
LEU A 628
GLY A 634
PRO A 635
 ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 ( 4.4A)
None
None
None
 0.66A 5vcyA-3lltA:
25.5		 5vcyA-3lltA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.40A 5vuiA-3lltA:
undetectable
5vuiB-3lltA:
undetectable		 5vuiA-3lltA:
21.60
5vuiB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.29A 5vuiA-3lltA:
undetectable
5vuiB-3lltA:
undetectable		 5vuiA-3lltA:
21.60
5vuiB-3lltA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.35A 5vuvA-3lltA:
undetectable
5vuvB-3lltA:
undetectable		 5vuvA-3lltA:
21.06
5vuvB-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.40A 5vuzA-3lltA:
undetectable
5vuzB-3lltA:
undetectable		 5vuzA-3lltA:
21.06
5vuzB-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV3_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.33A 5vv3A-3lltA:
undetectable
5vv3B-3lltA:
undetectable		 5vv3A-3lltA:
21.06
5vv3B-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.33A 5vv4A-3lltA:
undetectable
5vv4B-3lltA:
undetectable		 5vv4A-3lltA:
21.06
5vv4B-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VV5_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.45A 5vv5A-3lltA:
undetectable
5vv5B-3lltA:
undetectable		 5vv5A-3lltA:
21.06
5vv5B-3lltA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		5 / 12 GLY A 559
VAL A 566
ALA A 579
PHE A 630
GLY A 634
 ANP  A 877 (-3.8A)
ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
None
None
 0.71A 5xv7A-3lltA:
34.6		 5xv7A-3lltA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_B_8LXB501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		5 / 12 LEU A 665
CYH A 762
ILE A 789
ILE A 854
HIS A 782
 None
 0.98A 5y2tB-3lltA:
undetectable		 5y2tB-3lltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		7 / 12 ARG A 556
VAL A 566
ALA A 579
LYS A 581
GLU A 596
GLY A 634
LEU A 684
 None
ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
None
 0.87A 5y7zA-3lltA:
24.4		 5y7zA-3lltA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7Z_A_IREA401_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		7 / 12 ARG A 556
VAL A 566
ALA A 579
LYS A 581
GLU A 596
GLY A 634
LEU A 684
 None
ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
ANP  A 877 ( 4.4A)
None
None
 0.87A 5y7zA-3lltA:
24.4		 5y7zA-3lltA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		5 / 8 VAL A 566
LYS A 581
PHE A 630
ILE A 719
ASP A 720
 ANP  A 877 (-4.1A)
ANP  A 877 (-2.7A)
None
ANP  A 877 ( 4.3A)
ANP  A 877 (-2.9A)
 0.77A 5y9mA-3lltA:
26.7		 5y9mA-3lltA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 8 VAL A 566
LYS A 581
PHE A 630
ILE A 719
 ANP  A 877 (-4.1A)
ANP  A 877 (-2.7A)
None
ANP  A 877 ( 4.3A)
 0.39A 5y9mX-3lltA:
26.6		 5y9mX-3lltA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		5 / 7 VAL A 566
LYS A 581
PHE A 630
ILE A 719
ASP A 720
 ANP  A 877 (-4.1A)
ANP  A 877 (-2.7A)
None
ANP  A 877 ( 4.3A)
ANP  A 877 (-2.9A)
 0.90A 5yf9B-3lltA:
26.4		 5yf9B-3lltA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 LYS A 581
PHE A 630
ILE A 719
ASP A 720
 ANP  A 877 (-2.7A)
None
ANP  A 877 ( 4.3A)
ANP  A 877 (-2.9A)
 0.60A 5ywmX-3lltA:
26.3		 5ywmX-3lltA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 VAL A 566
LYS A 581
PHE A 630
ILE A 719
 ANP  A 877 (-4.1A)
ANP  A 877 (-2.7A)
None
ANP  A 877 ( 4.3A)
 0.45A 5ywmX-3lltA:
26.3		 5ywmX-3lltA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		3 / 3 LYS A 581
LEU A 684
ASP A 720
 ANP  A 877 (-2.7A)
None
ANP  A 877 (-2.9A)
 0.95A 5zv2A-3lltA:
21.1		 5zv2A-3lltA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.32A 6aurA-3lltA:
undetectable
6aurB-3lltA:
undetectable		 6aurA-3lltA:
16.25
6aurB-3lltA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUR_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.32A 6aurA-3lltA:
undetectable
6aurB-3lltA:
undetectable		 6aurA-3lltA:
16.25
6aurB-3lltA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUT_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.32A 6autA-3lltA:
undetectable
6autB-3lltA:
undetectable		 6autA-3lltA:
16.25
6autB-3lltA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUV_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.40A 6auvA-3lltA:
undetectable
6auvB-3lltA:
undetectable		 6auvA-3lltA:
16.25
6auvB-3lltA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUY_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.35A 6auyA-3lltA:
undetectable
6auyB-3lltA:
undetectable		 6auyA-3lltA:
17.43
6auyB-3lltA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUZ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.35A 6auzA-3lltA:
undetectable
6auzB-3lltA:
undetectable		 6auzA-3lltA:
17.43
6auzB-3lltA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUZ_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.33A 6auzA-3lltA:
undetectable
6auzB-3lltA:
undetectable		 6auzA-3lltA:
17.43
6auzB-3lltA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV0_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.32A 6av0A-3lltA:
undetectable
6av0B-3lltA:
undetectable		 6av0A-3lltA:
17.43
6av0B-3lltA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.38A 6av1A-3lltA:
undetectable
6av1B-3lltA:
undetectable		 6av1A-3lltA:
17.43
6av1B-3lltA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV1_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.41A 6av1A-3lltA:
undetectable
6av1B-3lltA:
undetectable		 6av1A-3lltA:
17.43
6av1B-3lltA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV2_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.34A 6av2A-3lltA:
undetectable
6av2B-3lltA:
undetectable		 6av2A-3lltA:
17.43
6av2B-3lltA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV3_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.34A 6av3A-3lltA:
undetectable
6av3B-3lltA:
undetectable		 6av3A-3lltA:
17.43
6av3B-3lltA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV4_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.33A 6av4A-3lltA:
undetectable
6av4B-3lltA:
undetectable		 6av4A-3lltA:
17.43
6av4B-3lltA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV5_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.35A 6av5A-3lltA:
undetectable
6av5B-3lltA:
undetectable		 6av5A-3lltA:
17.43
6av5B-3lltA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AV5_B_H4BB803_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.33A 6av5A-3lltA:
undetectable
6av5B-3lltA:
undetectable		 6av5A-3lltA:
17.43
6av5B-3lltA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.37A 6cicA-3lltA:
undetectable
6cicB-3lltA:
undetectable		 6cicA-3lltA:
17.43
6cicB-3lltA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CIC_B_H4BB802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.36A 6cicA-3lltA:
undetectable
6cicB-3lltA:
undetectable		 6cicA-3lltA:
17.43
6cicB-3lltA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 MET A 786
VAL A 832
TRP A 819
GLU A 787
 None
 1.34A 6cidA-3lltA:
undetectable
6cidB-3lltA:
undetectable		 6cidA-3lltA:
17.43
6cidB-3lltA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_B_H4BB803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3llt SERINE/THREONINE
KINASE-1, PFLAMMER
(Plasmodium
falciparum) 		4 / 7 TRP A 819
GLU A 787
MET A 786
VAL A 832
 None
 1.34A 6cidA-3lltA:
undetectable
6cidB-3lltA:
undetectable		 6cidA-3lltA:
17.43
6cidB-3lltA:
17.43