SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3llx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		4 / 8 GLY A 337
HIS A 338
ALA A   9
THR A  13
 None
CL  A 377 (-4.3A)
None
None
 0.69A 1gtnE-3llxA:
undetectable
1gtnF-3llxA:
undetectable		 1gtnE-3llxA:
12.02
1gtnF-3llxA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		4 / 8 GLY A 337
HIS A 338
ALA A   9
THR A  13
 None
CL  A 377 (-4.3A)
None
None
 0.76A 1gtnP-3llxA:
undetectable
1gtnQ-3llxA:
undetectable		 1gtnP-3llxA:
12.02
1gtnQ-3llxA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		4 / 4 HIS A 164
VAL A 121
THR A 166
LEU A 111
 None
 1.35A 1oq5A-3llxA:
undetectable		 1oq5A-3llxA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		3 / 3 SER A  36
ASP A 225
CYH A 192
 None
 1.15A 2br4E-3llxA:
undetectable		 2br4E-3llxA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		5 / 12 PHE A 226
ILE A 247
SER A 175
PHE A 222
HIS A 221
 None
None
None
None
EDO  A 384 (-4.5A)
 1.17A 2ft9A-3llxA:
undetectable		 2ft9A-3llxA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		5 / 12 ALA A 194
ALA A 158
ILE A 147
PHE A 165
LEU A 111
 None
 1.16A 2nyrA-3llxA:
undetectable		 2nyrA-3llxA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		5 / 11 LEU A 202
ILE A 207
GLY A 206
LEU A 154
SER A 152
 None
 0.97A 2qmmA-3llxA:
undetectable
2qmmB-3llxA:
undetectable		 2qmmA-3llxA:
18.06
2qmmB-3llxA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		5 / 9 LEU A 202
ILE A 207
GLY A 206
LEU A 154
SER A 152
 None
 1.06A 3ai9X-3llxA:
undetectable		 3ai9X-3llxA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		3 / 3 LEU A 168
GLU A 203
ILE A 207
 None
 0.54A 3czhA-3llxA:
undetectable		 3czhA-3llxA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		3 / 3 VAL A  34
LYS A  31
HIS A  44
 None
None
LLP  A  46 ( 3.6A)
 0.95A 3elzA-3llxA:
undetectable		 3elzA-3llxA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		5 / 12 ALA A 158
PHE A 165
GLY A 206
ALA A 198
ILE A 136
 None
 1.06A 4nkxD-3llxA:
undetectable		 4nkxD-3llxA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		3 / 3 CYH A 250
PRO A 218
ASP A 241
 None
 0.97A 4pm5A-3llxA:
undetectable		 4pm5A-3llxA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		4 / 8 ASP A  59
GLU A 231
ILE A 211
ASP A  83
 None
 1.00A 4xjeA-3llxA:
undetectable		 4xjeA-3llxA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		4 / 8 ASP A 241
GLY A 235
THR A  47
ASN A  26
 None
LLP  A  46 ( 3.5A)
LLP  A  46 ( 4.3A)
EDO  A 384 (-4.3A)
 1.04A 5hwaA-3llxA:
undetectable		 5hwaA-3llxA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		3 / 3 ALA A 198
ASN A 201
LEU A 202
 None
 0.49A 5i1nC-3llxA:
undetectable		 5i1nC-3llxA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		3 / 3 ALA A 198
ASN A 201
LEU A 202
 None
 0.48A 5i1pD-3llxA:
undetectable		 5i1pD-3llxA:
6.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		3 / 3 THR A 239
PRO A  43
ARG A 233
 None
None
LLP  A  46 ( 3.6A)
 0.86A 5nd7B-3llxA:
undetectable		 5nd7B-3llxA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		5 / 12 ASP A 151
LEU A 154
ARG A 144
GLY A  89
LEU A 111
 None
None
TRS  A 383 ( 3.4A)
EDO  A 387 (-3.7A)
None
 0.90A 6b0iB-3llxA:
undetectable		 6b0iB-3llxA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		4 / 9 VAL A 195
LEU A  85
VAL A 134
SER A 133
 None
 0.91A 6c2mD-3llxA:
undetectable		 6c2mD-3llxA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		4 / 6 TYR A 297
ASP A 294
GLN A 291
THR A 316
 None
EDO  A 385 (-3.7A)
EDO  A 391 ( 3.9A)
None
 1.46A 6djzA-3llxA:
undetectable		 6djzA-3llxA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		4 / 5 ALA A  87
TYR A  86
GLN A 117
ILE A  90
 LLP  A  46 ( 3.7A)
None
None
None
 1.30A 6g9bA-3llxA:
undetectable
6g9bB-3llxA:
undetectable		 6g9bA-3llxA:
13.01
6g9bB-3llxA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		3 / 3 ARG A 196
PHE A 187
PHE A 226
 None
 1.09A 6nknC-3llxA:
undetectable
6nknJ-3llxA:
undetectable		 6nknC-3llxA:
20.66
6nknJ-3llxA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 3llx PREDICTED AMINO ACID
ALDOLASE OR RACEMASE
(Idiomarina
loihiensis) 		4 / 7 ALA A 234
GLY A 235
GLY A 173
TYR A 176
 LLP  A  46 ( 3.8A)
LLP  A  46 ( 3.5A)
TRS  A 383 ( 3.9A)
TRS  A 383 ( 4.1A)
 0.85A 6nm4A-3llxA:
undetectable		 6nm4A-3llxA:
19.25