SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lm4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		3 / 3 TRP A 287
ALA A 191
VAL A 182
 None
 0.88A 1c4dC-3lm4A:
undetectable
1c4dD-3lm4A:
undetectable		 1c4dC-3lm4A:
5.17
1c4dD-3lm4A:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 12 HIS A 249
THR A 252
LEU A 303
HIS A 217
PHE A 270
 HPX  A 406 (-3.4A)
HPX  A 406 ( 3.8A)
None
FE  A 400 ( 3.4A)
None
 1.46A 1d4fC-3lm4A:
undetectable		 1d4fC-3lm4A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		4 / 6 LEU A 117
ILE A 153
TRP A  55
VAL A 202
 None
 1.05A 1db1A-3lm4A:
undetectable		 1db1A-3lm4A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NKI_A_PPFA5001_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 9 HIS A 217
SER A 254
TYR A 258
GLU A 268
HIS A 155
 FE  A 400 ( 3.4A)
HPX  A 406 ( 4.5A)
None
FE  A 400 (-2.7A)
FE  A 400 ( 3.5A)
 1.23A 1nkiA-3lm4A:
8.6
1nkiB-3lm4A:
8.5		 1nkiA-3lm4A:
18.15
1nkiB-3lm4A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NKI_B_PPFB5002_1
(PROBABLE FOSFOMYCIN
RESISTANCE PROTEIN)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 9 HIS A 155
HIS A 217
SER A 254
TYR A 258
GLU A 268
 FE  A 400 ( 3.5A)
FE  A 400 ( 3.4A)
HPX  A 406 ( 4.5A)
None
FE  A 400 (-2.7A)
 1.24A 1nkiA-3lm4A:
8.6
1nkiB-3lm4A:
8.5		 1nkiA-3lm4A:
18.15
1nkiB-3lm4A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		6 / 12 TYR A 222
ALA A 231
ILE A 148
VAL A 150
LEU A  57
PHE A  27
 None
 1.35A 1xozA-3lm4A:
undetectable		 1xozA-3lm4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		4 / 4 ARG A 181
GLY A 190
GLU A 188
SER A 254
 None
None
None
HPX  A 406 ( 4.5A)
 1.24A 2xctS-3lm4A:
undetectable
2xctU-3lm4A:
undetectable		 2xctS-3lm4A:
20.43
2xctU-3lm4A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		4 / 5 ALA A 244
GLY A 299
LYS A 248
HIS A 249
 None
None
None
HPX  A 406 (-3.4A)
 1.42A 2ylgA-3lm4A:
undetectable		 2ylgA-3lm4A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 11 HIS A 249
HIS A 217
ASN A 157
HIS A 155
VAL A 202
 HPX  A 406 (-3.4A)
FE  A 400 ( 3.4A)
PEO  A 401 ( 4.1A)
FE  A 400 ( 3.5A)
None
 1.24A 2zweA-3lm4A:
undetectable
2zweB-3lm4A:
undetectable		 2zweA-3lm4A:
22.54
2zweB-3lm4A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 11 HIS A 249
HIS A 217
ASN A 157
HIS A 155
VAL A 202
 HPX  A 406 (-3.4A)
FE  A 400 ( 3.4A)
PEO  A 401 ( 4.1A)
FE  A 400 ( 3.5A)
None
 1.23A 2zwfA-3lm4A:
undetectable
2zwfB-3lm4A:
undetectable		 2zwfA-3lm4A:
22.54
2zwfB-3lm4A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 11 HIS A 249
HIS A 217
ASN A 157
HIS A 155
VAL A 202
 HPX  A 406 (-3.4A)
FE  A 400 ( 3.4A)
PEO  A 401 ( 4.1A)
FE  A 400 ( 3.5A)
None
 1.24A 2zwgA-3lm4A:
undetectable
2zwgB-3lm4A:
undetectable		 2zwgA-3lm4A:
22.54
2zwgB-3lm4A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		4 / 7 PHE A 270
ASN A 228
HIS A 217
HIS A 155
 None
None
FE  A 400 ( 3.4A)
FE  A 400 ( 3.5A)
 1.13A 3t01A-3lm4A:
undetectable		 3t01A-3lm4A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 11 HIS A 217
TYR A 258
GLU A 268
HIS A 155
ALA A 203
 FE  A 400 ( 3.4A)
None
FE  A 400 (-2.7A)
FE  A 400 ( 3.5A)
PEO  A 401 ( 3.7A)
 0.60A 4ir0A-3lm4A:
7.6
4ir0B-3lm4A:
7.8		 4ir0A-3lm4A:
17.54
4ir0B-3lm4A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 11 HIS A 155
ALA A 203
HIS A 217
TYR A 258
GLU A 268
 FE  A 400 ( 3.5A)
PEO  A 401 ( 3.7A)
FE  A 400 ( 3.4A)
None
FE  A 400 (-2.7A)
 0.52A 4ir0A-3lm4A:
7.6
4ir0B-3lm4A:
7.8		 4ir0A-3lm4A:
17.54
4ir0B-3lm4A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 12 HIS A 217
TYR A 258
GLU A 268
HIS A 155
ALA A 203
 FE  A 400 ( 3.4A)
None
FE  A 400 (-2.7A)
FE  A 400 ( 3.5A)
PEO  A 401 ( 3.7A)
 0.55A 4jd1A-3lm4A:
7.2
4jd1B-3lm4A:
7.6		 4jd1A-3lm4A:
17.54
4jd1B-3lm4A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB 2)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 12 HIS A 155
ALA A 203
HIS A 217
TYR A 258
GLU A 268
 FE  A 400 ( 3.5A)
PEO  A 401 ( 3.7A)
FE  A 400 ( 3.4A)
None
FE  A 400 (-2.7A)
 0.64A 4jd1A-3lm4A:
7.2
4jd1B-3lm4A:
7.6		 4jd1A-3lm4A:
17.54
4jd1B-3lm4A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 12 HIS A 217
TYR A 258
GLU A 268
HIS A 155
ALA A 203
 FE  A 400 ( 3.4A)
None
FE  A 400 (-2.7A)
FE  A 400 ( 3.5A)
PEO  A 401 ( 3.7A)
 0.52A 4jh3A-3lm4A:
7.3
4jh3B-3lm4A:
7.4		 4jh3A-3lm4A:
18.34
4jh3B-3lm4A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 11 HIS A 155
ALA A 203
HIS A 217
TYR A 258
GLU A 268
 FE  A 400 ( 3.5A)
PEO  A 401 ( 3.7A)
FE  A 400 ( 3.4A)
None
FE  A 400 (-2.7A)
 0.49A 4jh3A-3lm4A:
7.3
4jh3B-3lm4A:
7.4		 4jh3A-3lm4A:
18.34
4jh3B-3lm4A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 11 HIS A 217
TYR A 258
GLU A 268
HIS A 155
ALA A 203
 FE  A 400 ( 3.4A)
None
FE  A 400 (-2.7A)
FE  A 400 ( 3.5A)
PEO  A 401 ( 3.7A)
 0.44A 4jh4A-3lm4A:
7.4
4jh4B-3lm4A:
7.3		 4jh4A-3lm4A:
18.34
4jh4B-3lm4A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 11 HIS A 155
ALA A 203
HIS A 217
TYR A 258
GLU A 268
 FE  A 400 ( 3.5A)
PEO  A 401 ( 3.7A)
FE  A 400 ( 3.4A)
None
FE  A 400 (-2.7A)
 0.47A 4jh4A-3lm4A:
7.4
4jh4B-3lm4A:
7.3		 4jh4A-3lm4A:
18.34
4jh4B-3lm4A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH5_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 11 HIS A 217
TYR A 258
GLU A 268
HIS A 155
ALA A 203
 FE  A 400 ( 3.4A)
None
FE  A 400 (-2.7A)
FE  A 400 ( 3.5A)
PEO  A 401 ( 3.7A)
 0.47A 4jh5A-3lm4A:
7.4
4jh5B-3lm4A:
7.3		 4jh5A-3lm4A:
18.34
4jh5B-3lm4A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH5_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 11 HIS A 155
ALA A 203
HIS A 217
TYR A 258
GLU A 268
 FE  A 400 ( 3.5A)
PEO  A 401 ( 3.7A)
FE  A 400 ( 3.4A)
None
FE  A 400 (-2.7A)
 0.50A 4jh5A-3lm4A:
7.4
4jh5B-3lm4A:
7.3		 4jh5A-3lm4A:
18.34
4jh5B-3lm4A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH6_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 10 HIS A 217
TYR A 258
GLU A 268
HIS A 155
ALA A 203
 FE  A 400 ( 3.4A)
None
FE  A 400 (-2.7A)
FE  A 400 ( 3.5A)
PEO  A 401 ( 3.7A)
 0.51A 4jh6A-3lm4A:
7.4
4jh6B-3lm4A:
7.4		 4jh6A-3lm4A:
18.34
4jh6B-3lm4A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH6_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 10 HIS A 155
ALA A 203
HIS A 217
TYR A 258
GLU A 268
 FE  A 400 ( 3.5A)
PEO  A 401 ( 3.7A)
FE  A 400 ( 3.4A)
None
FE  A 400 (-2.7A)
 0.52A 4jh6A-3lm4A:
7.4
4jh6B-3lm4A:
7.4		 4jh6A-3lm4A:
18.34
4jh6B-3lm4A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH8_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 10 HIS A 217
TYR A 258
GLU A 268
HIS A 155
ALA A 203
 FE  A 400 ( 3.4A)
None
FE  A 400 (-2.7A)
FE  A 400 ( 3.5A)
PEO  A 401 ( 3.7A)
 0.49A 4jh8A-3lm4A:
7.3
4jh8B-3lm4A:
7.3		 4jh8A-3lm4A:
18.34
4jh8B-3lm4A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH8_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 10 HIS A 155
ALA A 203
HIS A 217
TYR A 258
GLU A 268
 FE  A 400 ( 3.5A)
PEO  A 401 ( 3.7A)
FE  A 400 ( 3.4A)
None
FE  A 400 (-2.7A)
 0.49A 4jh8A-3lm4A:
7.3
4jh8B-3lm4A:
7.3		 4jh8A-3lm4A:
18.34
4jh8B-3lm4A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 12 HIS A 155
VAL A 182
MET A 289
MET A 205
HIS A 217
 FE  A 400 ( 3.5A)
None
HPX  A 406 ( 4.6A)
HPX  A 406 (-3.5A)
FE  A 400 ( 3.4A)
 1.45A 4o8fB-3lm4A:
undetectable		 4o8fB-3lm4A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 12 SER A 254
HIS A 155
VAL A 182
MET A 289
HIS A 217
 HPX  A 406 ( 4.5A)
FE  A 400 ( 3.5A)
None
HPX  A 406 ( 4.6A)
FE  A 400 ( 3.4A)
 1.41A 4o8fB-3lm4A:
undetectable		 4o8fB-3lm4A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		4 / 6 LEU A 215
HIS A 155
TYR A 258
GLU A 268
 None
FE  A 400 ( 3.5A)
None
FE  A 400 (-2.7A)
 0.82A 4pahA-3lm4A:
undetectable		 4pahA-3lm4A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_1
(ADENOSYLHOMOCYSTEINA
SE)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 12 HIS A 249
THR A 252
LEU A 303
HIS A 217
PHE A 270
 HPX  A 406 (-3.4A)
HPX  A 406 ( 3.8A)
None
FE  A 400 ( 3.4A)
None
 1.42A 4pfjB-3lm4A:
undetectable		 4pfjB-3lm4A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 12 THR A 178
ILE A 189
GLY A 190
VAL A 182
ILE A 292
 None
HPX  A 406 (-4.1A)
None
None
None
 1.00A 4rvgA-3lm4A:
undetectable		 4rvgA-3lm4A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		4 / 5 ALA A 244
GLY A 299
LYS A 248
HIS A 249
 None
None
None
HPX  A 406 (-3.4A)
 1.47A 5jliA-3lm4A:
undetectable		 5jliA-3lm4A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 12 THR A 106
GLY A  94
ALA A  84
THR A  88
SER A  97
 None
 1.11A 5lf3b-3lm4A:
undetectable		 5lf3b-3lm4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 12 THR A 106
GLY A  94
ALA A  84
THR A  88
SER A  97
 None
 1.10A 5lf3N-3lm4A:
undetectable		 5lf3N-3lm4A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		3 / 3 GLU A  50
ARG A 139
TYR A  49
 None
 0.59A 5trqB-3lm4A:
undetectable		 5trqB-3lm4A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		3 / 3 GLU A  98
TYR A 103
ARG A  13
 None
 0.84A 5uunA-3lm4A:
undetectable		 5uunA-3lm4A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		3 / 3 GLU A  98
TYR A 103
ARG A  13
 None
 0.70A 5uunB-3lm4A:
undetectable		 5uunB-3lm4A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 11 HIS A 249
HIS A 217
ASN A 157
HIS A 155
VAL A 202
 HPX  A 406 (-3.4A)
FE  A 400 ( 3.4A)
PEO  A 401 ( 4.1A)
FE  A 400 ( 3.5A)
None
 1.20A 5z0fA-3lm4A:
undetectable
5z0fB-3lm4A:
undetectable		 5z0fA-3lm4A:
12.06
5z0fB-3lm4A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 11 HIS A 249
HIS A 217
ASN A 157
HIS A 155
VAL A 202
 HPX  A 406 (-3.4A)
FE  A 400 ( 3.4A)
PEO  A 401 ( 4.1A)
FE  A 400 ( 3.5A)
None
 1.20A 5z0gA-3lm4A:
undetectable
5z0gB-3lm4A:
undetectable		 5z0gA-3lm4A:
12.06
5z0gB-3lm4A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 11 HIS A 249
HIS A 217
ASN A 157
HIS A 155
VAL A 202
 HPX  A 406 (-3.4A)
FE  A 400 ( 3.4A)
PEO  A 401 ( 4.1A)
FE  A 400 ( 3.5A)
None
 1.22A 5z0hA-3lm4A:
undetectable
5z0hB-3lm4A:
undetectable		 5z0hA-3lm4A:
12.06
5z0hB-3lm4A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 11 HIS A 249
HIS A 217
ASN A 157
HIS A 155
VAL A 202
 HPX  A 406 (-3.4A)
FE  A 400 ( 3.4A)
PEO  A 401 ( 4.1A)
FE  A 400 ( 3.5A)
None
 1.21A 5z0iA-3lm4A:
undetectable
5z0iB-3lm4A:
undetectable		 5z0iA-3lm4A:
12.06
5z0iB-3lm4A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 11 HIS A 249
HIS A 217
ASN A 157
HIS A 155
VAL A 202
 HPX  A 406 (-3.4A)
FE  A 400 ( 3.4A)
PEO  A 401 ( 4.1A)
FE  A 400 ( 3.5A)
None
 1.22A 5z0jA-3lm4A:
undetectable
5z0jB-3lm4A:
undetectable		 5z0jA-3lm4A:
12.06
5z0jB-3lm4A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 11 HIS A 249
HIS A 217
ASN A 157
HIS A 155
VAL A 202
 HPX  A 406 (-3.4A)
FE  A 400 ( 3.4A)
PEO  A 401 ( 4.1A)
FE  A 400 ( 3.5A)
None
 1.22A 5z0kA-3lm4A:
undetectable
5z0kB-3lm4A:
undetectable		 5z0kA-3lm4A:
12.06
5z0kB-3lm4A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 11 HIS A 249
HIS A 217
ASN A 157
HIS A 155
VAL A 202
 HPX  A 406 (-3.4A)
FE  A 400 ( 3.4A)
PEO  A 401 ( 4.1A)
FE  A 400 ( 3.5A)
None
 1.21A 5z0lA-3lm4A:
undetectable
5z0lB-3lm4A:
undetectable		 5z0lA-3lm4A:
12.06
5z0lB-3lm4A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 11 HIS A 249
HIS A 217
ASN A 157
HIS A 155
VAL A 202
 HPX  A 406 (-3.4A)
FE  A 400 ( 3.4A)
PEO  A 401 ( 4.1A)
FE  A 400 ( 3.5A)
None
 1.25A 5z0mA-3lm4A:
undetectable
5z0mB-3lm4A:
undetectable		 5z0mA-3lm4A:
12.06
5z0mB-3lm4A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		5 / 12 PHE A 309
ALA A 165
THR A 178
ILE A 251
MET A 289
 HPX  A 406 (-4.7A)
None
None
HPX  A 406 ( 3.9A)
HPX  A 406 ( 4.6A)
 1.15A 6aybA-3lm4A:
undetectable		 6aybA-3lm4A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6PAH_A_DAHA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 3lm4 CATECHOL
2,3-DIOXYGENASE
(Rhodococcus
jostii) 		4 / 6 LEU A 215
HIS A 155
TYR A 258
GLU A 268
 None
FE  A 400 ( 3.5A)
None
FE  A 400 (-2.7A)
 0.87A 6pahA-3lm4A:
undetectable		 6pahA-3lm4A:
23.51