SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lm5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 8 TYR A 226
THR A 232
VAL A 262
ASP A 253
 None
 1.16A 1dz9A-3lm5A:
undetectable		 1dz9A-3lm5A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		3 / 3 ASN A  95
PHE A 180
VAL A  93
 None
 0.83A 1kijA-3lm5A:
undetectable		 1kijA-3lm5A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M17_A_AQ4A999_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 12 LEU A  39
ALA A  60
LYS A  62
LEU A 108
GLY A 116
LEU A 165
ASP A 179
 QUE  A   1 ( 3.8A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
None
None
None
QUE  A   1 (-2.9A)
 0.93A 1m17A-3lm5A:
24.8		 1m17A-3lm5A:
24.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 9 LEU A  39
GLY A  40
VAL A  47
ALA A  60
TYR A 112
ALA A 113
LEU A 165
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
 0.71A 1muoA-3lm5A:
15.1		 1muoA-3lm5A:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 7 ASN A 163
HIS A 156
PHE A 180
ILE A 142
 None
 1.24A 1tdnA-3lm5A:
undetectable		 1tdnA-3lm5A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 8 TYR A 226
THR A 232
VAL A 262
ASP A 253
 None
 1.16A 1uyuA-3lm5A:
undetectable		 1uyuA-3lm5A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_B_CAMB1416_0
(CYTOCHROME P450-CAM)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 8 TYR A 226
THR A 232
VAL A 262
ASP A 253
 None
 1.13A 1uyuB-3lm5A:
undetectable		 1uyuB-3lm5A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XBB_A_STIA1_1
(TYROSINE-PROTEIN
KINASE SYK)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 9 LEU A  39
VAL A  47
ALA A  60
ALA A 113
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.9A)
None
None
 0.73A 1xbbA-3lm5A:
26.9		 1xbbA-3lm5A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 9 LEU A  39
VAL A  47
LYS A  62
LEU A  96
LEU A 108
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.1A)
None
None
 0.78A 1xkkA-3lm5A:
23.3		 1xkkA-3lm5A:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 10 LEU A  39
ALA A  60
ILE A  94
LEU A 110
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.1A)
None
 0.63A 1yi4A-3lm5A:
26.7		 1yi4A-3lm5A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 11 GLY A  40
VAL A  47
ALA A  60
TYR A 112
ALA A 113
LEU A 165
ASP A 179
 None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
QUE  A   1 (-2.9A)
 0.66A 2evaA-3lm5A:
24.6		 2evaA-3lm5A:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_A_MIXA539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 12 LEU A  39
GLY A  40
VAL A  47
ALA A  60
ASP A 158
LYS A 160
ASN A 163
ASP A 179
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
None
None
None
QUE  A   1 (-2.9A)
 0.75A 2fumA-3lm5A:
27.6		 2fumA-3lm5A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_B_MIXB1539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 12 LEU A  39
GLY A  40
VAL A  47
ALA A  60
TYR A 112
LYS A 160
ASN A 163
ASP A 179
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
None
None
QUE  A   1 (-2.9A)
 0.81A 2fumB-3lm5A:
27.6		 2fumB-3lm5A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 12 LEU A  39
GLY A  40
VAL A  47
ALA A  60
TYR A 112
ASN A 163
ASP A 179
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
None
QUE  A   1 (-2.9A)
 0.67A 2fumC-3lm5A:
25.8		 2fumC-3lm5A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 12 LEU A  39
GLY A  40
VAL A  47
ALA A  60
LYS A 160
ASN A 163
ASP A 179
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
None
None
QUE  A   1 (-2.9A)
 0.65A 2fumD-3lm5A:
26.1		 2fumD-3lm5A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 12 LEU A  39
GLY A  40
VAL A  47
LEU A  84
LEU A 108
TYR A 112
ALA A 113
ASP A 179
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 ( 4.6A)
None
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
QUE  A   1 (-2.9A)
 0.56A 2ivuA-3lm5A:
25.8		 2ivuA-3lm5A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 12 LEU A  39
GLY A  40
VAL A  47
LEU A 108
TYR A 112
ALA A 113
LEU A 165
ASP A 179
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
None
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
QUE  A   1 (-2.9A)
 0.67A 2ivuA-3lm5A:
25.8		 2ivuA-3lm5A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 12 ILE A  81
ILE A  77
LEU A 108
ARG A  68
ILE A  94
 None
None
None
None
QUE  A   1 (-4.6A)
 0.98A 2nnhA-3lm5A:
undetectable		 2nnhA-3lm5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 10 ILE A  81
ILE A  77
LEU A 108
ARG A  68
ILE A  94
 None
None
None
None
QUE  A   1 (-4.6A)
 0.97A 2nnhB-3lm5A:
undetectable		 2nnhB-3lm5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 12 GLY A  40
VAL A  47
ALA A  60
LEU A 110
TYR A 112
GLY A 116
 None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.9A)
None
 0.72A 2wgjA-3lm5A:
8.4		 2wgjA-3lm5A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 10 LEU A 228
LEU A 121
SER A 167
LEU A 166
LEU A 138
 None
 1.14A 2xn7A-3lm5A:
undetectable
2xn7B-3lm5A:
undetectable		 2xn7A-3lm5A:
20.87
2xn7B-3lm5A:
7.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_A_B49A1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 12 VAL A  47
ALA A  60
ILE A  94
GLY A 116
GLU A 117
LEU A 165
ASP A 179
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.6A)
None
None
None
QUE  A   1 (-2.9A)
 0.74A 2y7jA-3lm5A:
31.9		 2y7jA-3lm5A:
30.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Y7J_B_B49B1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 10 VAL A  47
ALA A  60
ILE A  94
GLY A 116
LEU A 165
ASP A 179
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.6A)
None
None
QUE  A   1 (-2.9A)
 0.79A 2y7jB-3lm5A:
31.9		 2y7jB-3lm5A:
30.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 12 VAL A  47
ALA A  60
LYS A  62
LEU A 108
GLY A 116
LEU A 165
ASP A 179
PHE A 180
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
None
None
None
QUE  A   1 (-2.9A)
None
 0.97A 3bbtD-3lm5A:
12.6		 3bbtD-3lm5A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 6 LEU A  39
VAL A  47
LYS A  62
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.1A)
None
 0.72A 3cs9D-3lm5A:
22.4		 3cs9D-3lm5A:
27.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0E_A_B49A9000_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 11 LEU A  39
VAL A  47
ALA A  60
TYR A 112
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
None
None
 0.41A 3g0eA-3lm5A:
22.4		 3g0eA-3lm5A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_A_B49A9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 11 LEU A  39
VAL A  47
ALA A  60
TYR A 112
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
None
None
 0.45A 3g0fA-3lm5A:
23.4		 3g0fA-3lm5A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G0F_B_B49B9001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 10 LEU A  39
VAL A  47
ALA A  60
TYR A 112
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
None
None
 0.47A 3g0fB-3lm5A:
23.5		 3g0fB-3lm5A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 7 LYS A  62
VAL A  93
LEU A 108
ILE A 177
 QUE  A   1 (-4.1A)
None
None
None
 0.49A 3gp0A-3lm5A:
24.0		 3gp0A-3lm5A:
27.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 6 GLN A 141
LEU A 143
GLU A 144
LEU A 288
 None
 0.85A 3h5gA-3lm5A:
undetectable
3h5gC-3lm5A:
undetectable		 3h5gA-3lm5A:
6.12
3h5gC-3lm5A:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 6 VAL A  93
ILE A 154
HIS A 156
ILE A 177
 None
 0.34A 3hegA-3lm5A:
17.9		 3hegA-3lm5A:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		3 / 3 THR A 103
LYS A  53
GLU A 105
 None
 0.97A 3ijdB-3lm5A:
undetectable		 3ijdB-3lm5A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXK_A_MI1A1125_1
(TYROSINE-PROTEIN
KINASE JAK3)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 12 LEU A  39
GLY A  40
VAL A  47
ALA A  60
LYS A  62
TYR A 112
LEU A 165
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.9A)
None
 0.78A 3lxkA-3lm5A:
25.6		 3lxkA-3lm5A:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXN_A_MI1A1_1
(NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 12 LEU A  39
GLY A  40
VAL A  47
ALA A  60
LYS A  62
ILE A  94
TYR A 112
LEU A 165
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
None
 0.70A 3lxnA-3lm5A:
25.5		 3lxnA-3lm5A:
28.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OEZ_B_STIB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 12 VAL A  47
ALA A  60
LYS A  62
GLU A  80
VAL A  83
TYR A 112
LEU A 165
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-3.1A)
None
QUE  A   1 (-4.9A)
None
 0.80A 3oezB-3lm5A:
24.4		 3oezB-3lm5A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_1
(P38A)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 12 GLY A  40
VAL A  47
ALA A  60
LEU A  84
ILE A  94
 None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.6A)
 0.51A 3ohtB-3lm5A:
6.9		 3ohtB-3lm5A:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		9 / 12 VAL A  47
ALA A  60
GLU A  80
LEU A  84
ILE A  94
TYR A 112
ALA A 113
LEU A 149
HIS A 156
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
None
 0.90A 3rgfA-3lm5A:
18.4		 3rgfA-3lm5A:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 12 LEU A  64
PHE A 180
ILE A 118
VAL A  47
ILE A  94
 None
None
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.6A)
 1.12A 3sp9A-3lm5A:
undetectable		 3sp9A-3lm5A:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG2_A_IREA1_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 12 LEU A  39
VAL A  47
ALA A  60
LYS A  62
LEU A 108
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
None
None
None
 0.86A 3ug2A-3lm5A:
24.1		 3ug2A-3lm5A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 6 GLU A 144
GLY A 145
LEU A 288
TYR A 147
 None
 0.98A 3w9tB-3lm5A:
undetectable		 3w9tB-3lm5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 6 GLU A 144
GLY A 145
LEU A 288
TYR A 147
 None
 0.98A 3w9tE-3lm5A:
undetectable		 3w9tE-3lm5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 6 GLU A 144
GLY A 145
LEU A 288
TYR A 147
 None
 0.97A 3w9tF-3lm5A:
undetectable		 3w9tF-3lm5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 9 ALA A 203
LEU A 157
ASP A 210
ASN A 208
ILE A 212
 None
 1.21A 3wdmC-3lm5A:
undetectable		 3wdmC-3lm5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 12 LEU A  39
VAL A  47
ALA A  60
LEU A  84
GLY A 116
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 ( 4.6A)
None
 0.51A 3wzdA-3lm5A:
23.3		 3wzdA-3lm5A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 12 LEU A  39
VAL A  47
ALA A  60
LEU A  84
GLY A 116
LEU A 149
HIS A 156
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 ( 4.6A)
None
None
None
 0.55A 3wzeA-3lm5A:
23.8		 3wzeA-3lm5A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 12 LEU A  84
ASP A 158
LYS A 160
ASN A 163
ASP A 179
GLY A 197
 QUE  A   1 ( 4.6A)
None
None
None
QUE  A   1 (-2.9A)
None
 1.09A 4an2A-3lm5A:
24.1		 4an2A-3lm5A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 12 LEU A 108
LEU A  84
ASP A 158
LYS A 160
ASN A 163
ASP A 179
 None
QUE  A   1 ( 4.6A)
None
None
None
QUE  A   1 (-2.9A)
 1.47A 4an2A-3lm5A:
24.1		 4an2A-3lm5A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 12 LEU A 108
LEU A  84
LYS A 160
ASN A 163
ASP A 179
GLY A 181
 None
QUE  A   1 ( 4.6A)
None
None
QUE  A   1 (-2.9A)
None
 1.42A 4an2A-3lm5A:
24.1		 4an2A-3lm5A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 12 LEU A 108
LEU A 110
ASP A 158
LYS A 160
ASN A 163
ASP A 179
 None
QUE  A   1 (-4.1A)
None
None
None
QUE  A   1 (-2.9A)
 1.45A 4an2A-3lm5A:
24.1		 4an2A-3lm5A:
26.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 12 LEU A  39
VAL A  47
ALA A  60
GLU A  80
LEU A  84
GLY A 116
LEU A 149
HIS A 156
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 ( 4.6A)
None
None
None
 0.77A 4asdA-3lm5A:
23.6		 4asdA-3lm5A:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 11 LEU A  39
GLY A  40
VAL A  47
ALA A  60
TYR A 112
ALA A 113
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
None
 0.79A 4ckiA-3lm5A:
25.5		 4ckiA-3lm5A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKJ_A_ADNA2014_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 10 LEU A  39
GLY A  40
GLY A  42
VAL A  47
ALA A  60
TYR A 112
ALA A 113
LEU A 165
 QUE  A   1 ( 3.8A)
None
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
 0.64A 4ckjA-3lm5A:
26.2		 4ckjA-3lm5A:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 10 GLY A 222
ALA A 225
ILE A 139
ILE A 175
ILE A 118
 None
 1.11A 4dt8B-3lm5A:
5.5		 4dt8B-3lm5A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I22_A_IREA9001_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 12 LEU A  39
GLY A  40
VAL A  47
ALA A  60
LYS A  62
LEU A 108
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
None
None
None
 0.85A 4i22A-3lm5A:
12.6		 4i22A-3lm5A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 12 VAL A  47
ALA A  60
ILE A  94
ASP A 158
LYS A 160
ASN A 163
LEU A 165
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.6A)
None
None
None
None
 0.67A 4i41A-3lm5A:
26.8		 4i41A-3lm5A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFG_A_1E8A601_1
(CALMODULIN-DOMAIN
PROTEIN KINASE 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 12 GLY A  40
VAL A  47
ALA A  60
LEU A  96
LEU A 108
GLY A 116
GLU A 117
LEU A 165
 None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
None
None
None
None
None
 0.55A 4ifgA-3lm5A:
26.1		 4ifgA-3lm5A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 8 TYR A 226
THR A 232
VAL A 262
ASP A 253
 None
 1.12A 4l4eA-3lm5A:
undetectable		 4l4eA-3lm5A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 8 TYR A 226
THR A 232
VAL A 262
ASP A 253
 None
 1.11A 4l4fA-3lm5A:
undetectable		 4l4fA-3lm5A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9I_A_8PRA601_1
(RHODOPSIN KINASE)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 7 VAL A  47
ALA A  60
LEU A  64
LEU A 165
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
None
None
 0.69A 4l9iA-3lm5A:
9.2		 4l9iA-3lm5A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_1
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 12 LEU A  84
ASN A 163
ASP A 179
PHE A 180
GLY A 181
LEU A  64
 QUE  A   1 ( 4.6A)
None
QUE  A   1 (-2.9A)
None
None
None
 1.27A 4lmnA-3lm5A:
23.5		 4lmnA-3lm5A:
26.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 11 LEU A  39
GLY A  40
VAL A  47
ALA A  60
ASN A 163
LEU A 165
ASP A 179
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
None
None
QUE  A   1 (-2.9A)
 0.47A 4o0sA-3lm5A:
30.4		 4o0sA-3lm5A:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0S_A_ADNA500_1
(AURORA KINASE A)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 11 LEU A  39
GLY A  40
VAL A  47
ALA A  60
LYS A  62
ASN A 163
ASP A 179
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
None
QUE  A   1 (-2.9A)
 0.88A 4o0sA-3lm5A:
30.4		 4o0sA-3lm5A:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0W_A_ADNA501_1
(AURORA KINASE A)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 6 LEU A  39
GLY A  40
VAL A  47
ALA A  60
LEU A 165
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
None
 0.32A 4o0wA-3lm5A:
29.5		 4o0wA-3lm5A:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OGR_E_ADNE401_1
(CYCLIN-DEPENDENT
KINASE 9)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 7 GLY A  40
ALA A  60
ASN A 163
LEU A 165
ASP A 179
 None
QUE  A   1 (-3.2A)
None
None
QUE  A   1 (-2.9A)
 1.00A 4ogrE-3lm5A:
27.2		 4ogrE-3lm5A:
28.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_A_RXTA601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 11 LEU A  39
GLY A  42
VAL A  47
ALA A  60
TYR A 112
GLY A 116
ASN A 163
LEU A 165
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
None
None
None
 0.74A 4u5jA-3lm5A:
26.8		 4u5jA-3lm5A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U5J_B_RXTB601_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 9 LEU A  39
VAL A  47
ALA A  60
TYR A 112
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.9A)
None
None
 0.75A 4u5jB-3lm5A:
14.0		 4u5jB-3lm5A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 7 VAL A  47
LYS A  62
ILE A  94
ALA A 113
ILE A 177
 QUE  A   1 ( 4.6A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.6A)
QUE  A   1 (-3.9A)
None
 0.59A 4uxqA-3lm5A:
23.8		 4uxqA-3lm5A:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 12 ALA A  60
GLU A  80
ALA A 113
LEU A 149
HIS A 156
 QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-3.9A)
None
None
 0.85A 4v01A-3lm5A:
23.3		 4v01A-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 9 LEU A  39
VAL A  47
LYS A  62
ILE A  94
TYR A 112
LEU A 165
ILE A 177
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
None
None
 0.79A 4v01A-3lm5A:
23.3		 4v01A-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 12 ALA A  60
GLU A  80
ALA A 113
LEU A 149
HIS A 156
 QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-3.9A)
None
None
 0.78A 4v01B-3lm5A:
24.1		 4v01B-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 9 LEU A  39
VAL A  47
ILE A  94
TYR A 112
LEU A 165
ILE A 177
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
None
None
 0.70A 4v01B-3lm5A:
24.1		 4v01B-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 9 LEU A  39
VAL A  47
LYS A  62
TYR A 112
LEU A 165
ILE A 177
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.9A)
None
None
 0.88A 4v01B-3lm5A:
24.1		 4v01B-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 12 VAL A  47
ALA A  60
GLU A  80
ALA A 113
LEU A 149
HIS A 156
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-3.9A)
None
None
 0.86A 4v04A-3lm5A:
23.3		 4v04A-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 8 LYS A  62
ILE A  94
TYR A 112
ILE A 177
 QUE  A   1 (-4.1A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
None
 0.75A 4v04A-3lm5A:
23.3		 4v04A-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 8 LYS A  62
TYR A 112
LEU A 165
ILE A 177
 QUE  A   1 (-4.1A)
QUE  A   1 (-4.9A)
None
None
 0.71A 4v04A-3lm5A:
23.3		 4v04A-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 10 LEU A  39
VAL A  47
LYS A  62
ILE A  94
TYR A 112
LEU A 165
ILE A 177
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
None
None
 0.71A 4v04B-3lm5A:
24.1		 4v04B-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		5 / 12 ALA A  60
GLU A  80
ALA A 113
LEU A 149
HIS A 156
 QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-3.9A)
None
None
 0.86A 4v04B-3lm5A:
24.1		 4v04B-3lm5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAB_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 10 LEU A  39
VAL A  47
ALA A  60
LYS A  62
LEU A 110
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.1A)
None
None
 0.86A 5aabA-3lm5A:
25.1		 5aabA-3lm5A:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AAC_A_VGHA9000_1
(ALK TYROSINE KINASE
RECEPTOR)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 10 LEU A  39
VAL A  47
ALA A  60
LYS A  62
LEU A 110
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.1A)
None
None
 0.85A 5aacA-3lm5A:
25.0		 5aacA-3lm5A:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 12 LEU A  39
VAL A  47
ALA A  60
GLU A  80
ILE A  94
TYR A 112
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
None
None
 0.87A 5bvwA-3lm5A:
23.2		 5bvwA-3lm5A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 12 LEU A  39
VAL A  47
ALA A  60
LYS A  62
ILE A  94
TYR A 112
GLY A 116
LEU A 165
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
None
None
 0.84A 5bvwA-3lm5A:
23.2		 5bvwA-3lm5A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 12 VAL A  47
ALA A  60
ILE A  94
TYR A 112
ALA A 113
PHE A 180
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
 0.91A 5hesA-3lm5A:
10.4		 5hesA-3lm5A:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9X_A_DB8A1001_1
(EPHRIN TYPE-A
RECEPTOR 2)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 12 ALA A  60
LYS A  62
ILE A  94
TYR A 112
GLY A 116
LEU A 165
 QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.6A)
QUE  A   1 (-4.9A)
None
None
 0.71A 5i9xA-3lm5A:
24.6		 5i9xA-3lm5A:
27.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 6 PHE A 235
VAL A 252
TYR A 254
ILE A 270
 None
 1.24A 5iwuA-3lm5A:
5.3		 5iwuA-3lm5A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 7 GLY A  40
GLY A  42
LEU A  64
GLU A 117
 None
 0.43A 5izfA-3lm5A:
26.2		 5izfA-3lm5A:
27.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 7 HIS A  79
HIS A 156
ILE A 154
VAL A 155
 None
 1.01A 5kkzC-3lm5A:
undetectable
5kkzE-3lm5A:
undetectable		 5kkzC-3lm5A:
20.18
5kkzE-3lm5A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 7 HIS A 156
ILE A 154
VAL A 155
HIS A  79
 None
 1.01A 5kkzK-3lm5A:
undetectable
5kkzQ-3lm5A:
undetectable		 5kkzK-3lm5A:
21.56
5kkzQ-3lm5A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 7 HIS A  79
HIS A 156
ILE A 154
VAL A 155
 None
 1.04A 5kkzM-3lm5A:
undetectable
5kkzO-3lm5A:
undetectable		 5kkzM-3lm5A:
20.18
5kkzO-3lm5A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		3 / 3 LYS A  62
GLN A 162
ASN A 163
 QUE  A   1 (-4.1A)
None
None
 0.81A 5l2tA-3lm5A:
11.1		 5l2tA-3lm5A:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		9 / 11 LEU A  39
GLY A  40
VAL A  47
ALA A  60
LEU A 110
TYR A 112
ALA A 113
GLU A 117
LEU A 165
 QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
None
 0.44A 5lvnA-3lm5A:
29.3		 5lvnA-3lm5A:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		8 / 12 GLY A  40
VAL A  47
ALA A  60
GLU A  80
LEU A 110
TYR A 112
GLY A 116
GLU A 117
 None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-4.1A)
QUE  A   1 (-4.9A)
None
None
 0.74A 5mafA-3lm5A:
29.4		 5mafA-3lm5A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		4 / 7 TYR A 254
TYR A 226
GLN A 264
ASP A 268
 None
 1.18A 5ov9B-3lm5A:
undetectable		 5ov9B-3lm5A:
19.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5VCY_A_DB8A401_1
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 12 LEU A  39
VAL A  47
ALA A  60
LYS A  62
LEU A 108
GLY A 115
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
None
None
 0.96A 5vcyA-3lm5A:
26.2		 5vcyA-3lm5A:
31.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		7 / 12 LEU A  39
VAL A  47
ALA A  60
GLU A  80
TYR A 112
ALA A 113
GLY A 116
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
 0.67A 5zv2A-3lm5A:
23.5		 5zv2A-3lm5A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		3 / 3 LYS A  62
LEU A 165
ASP A 179
 QUE  A   1 (-4.1A)
None
QUE  A   1 (-2.9A)
 0.82A 5zv2A-3lm5A:
23.5		 5zv2A-3lm5A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 12 LEU A  39
VAL A  47
ALA A  60
GLU A  80
ALA A 113
GLY A 116
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-3.1A)
QUE  A   1 (-3.9A)
None
 0.63A 5zv2B-3lm5A:
23.9		 5zv2B-3lm5A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		6 / 12 LEU A  39
VAL A  47
ALA A  60
LYS A  62
ALA A 113
GLY A 116
 QUE  A   1 ( 3.8A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-3.9A)
None
 0.58A 5zv2B-3lm5A:
23.9		 5zv2B-3lm5A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens) 		3 / 3 TYR A 112
LEU A 165
ASP A 179
 QUE  A   1 (-4.9A)
None
QUE  A   1 (-2.9A)
 0.71A 5zv2B-3lm5A:
23.8		 5zv2B-3lm5A:
12.81