SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lm8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3lm8 THIAMINE
PYROPHOSPHOKINASE
(Bacillus
subtilis) 		3 / 3 LYS A 119
ASP A  51
ASP A  83
 None
MG  A 225 (-3.8A)
None
 0.97A 2br4D-3lm8A:
undetectable		 2br4D-3lm8A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 3lm8 THIAMINE
PYROPHOSPHOKINASE
(Bacillus
subtilis) 		4 / 8 LEU A  86
ILE A   6
GLY A 101
ILE A 102
 None
 0.90A 3wxoA-3lm8A:
undetectable		 3wxoA-3lm8A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 3lm8 THIAMINE
PYROPHOSPHOKINASE
(Bacillus
subtilis) 		3 / 3 ARG A 211
ARG A 128
ILE A 155
 None
 0.91A 4b7qA-3lm8A:
undetectable		 4b7qA-3lm8A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_C_ZMRC601_2
(NEURAMINIDASE)		 3lm8 THIAMINE
PYROPHOSPHOKINASE
(Bacillus
subtilis) 		3 / 3 ARG A 211
ARG A 128
ILE A 155
 None
 0.67A 4b7qC-3lm8A:
undetectable		 4b7qC-3lm8A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 3lm8 THIAMINE
PYROPHOSPHOKINASE
(Bacillus
subtilis) 		3 / 3 ASN A 113
ASP A  32
GLY A  34
 None
 0.57A 5fctB-3lm8A:
undetectable		 5fctB-3lm8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3lm8 THIAMINE
PYROPHOSPHOKINASE
(Bacillus
subtilis) 		3 / 3 SER A 156
LEU A 117
MET A 138
 None
 0.84A 5ikrB-3lm8A:
undetectable		 5ikrB-3lm8A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 3lm8 THIAMINE
PYROPHOSPHOKINASE
(Bacillus
subtilis) 		4 / 6 PRO A 159
LEU A 207
PHE A 160
LEU A 183
 None
 1.18A 5tl8A-3lm8A:
undetectable		 5tl8A-3lm8A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3lm8 THIAMINE
PYROPHOSPHOKINASE
(Bacillus
subtilis) 		3 / 3 GLN A  98
TYR A  21
ASN A   5
 None
 1.05A 6dwdC-3lm8A:
undetectable		 6dwdC-3lm8A:
15.45