SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lmc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		4 / 5 HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.26A 1os2A-3lmcA:
5.5		 1os2A-3lmcA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_D_HAED574_1
(MACROPHAGE
METALLOELASTASE)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		4 / 4 HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.25A 1os2D-3lmcA:
5.8		 1os2D-3lmcA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTT_A_HAEA1265_1
(MACROPHAGE
METALLOELASTASE)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		4 / 4 HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.27A 1uttA-3lmcA:
8.1		 1uttA-3lmcA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_A_HAEA1267_1
(MACROPHAGE
METALLOELASTASE)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		4 / 4 HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.29A 1utzA-3lmcA:
8.1		 1utzA-3lmcA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTZ_B_HAEB1266_1
(MACROPHAGE
METALLOELASTASE)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		4 / 4 HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.28A 1utzB-3lmcA:
8.1		 1utzB-3lmcA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		4 / 6 HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.25A 1y93A-3lmcA:
8.2		 1y93A-3lmcA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_N_CUN517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		3 / 3 HIS A 159
HIS A 153
HIS A 149
 ZN  A 212 (-3.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.4A)
 0.73A 2einN-3lmcA:
undetectable		 2einN-3lmcA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HU6_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		4 / 4 HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.21A 2hu6A-3lmcA:
8.2		 2hu6A-3lmcA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		5 / 9 HIS A 149
GLU A 150
HIS A 153
HIS A 159
LEU A 176
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
None
 0.70A 2jihA-3lmcA:
12.5		 2jihA-3lmcA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_B_097B1001_1
(ADAMTS-1)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		4 / 8 HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.19A 2jihB-3lmcA:
12.7		 2jihB-3lmcA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		4 / 6 HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.26A 2ow9A-3lmcA:
7.3		 2ow9A-3lmcA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_B_HAEB502_1
(COLLAGENASE 3)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		4 / 4 HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.28A 2ow9B-3lmcA:
6.9		 2ow9B-3lmcA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_C_HAEC3001_1
(COLLAGENASE 3)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		4 / 4 HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.30A 2ozrC-3lmcA:
5.5		 2ozrC-3lmcA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_D_HAED3002_1
(COLLAGENASE 3)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		4 / 4 HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.28A 2ozrD-3lmcA:
5.4		 2ozrD-3lmcA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_E_HAEE3003_1
(COLLAGENASE 3)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		4 / 4 HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.30A 2ozrE-3lmcA:
5.8		 2ozrE-3lmcA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		3 / 3 HIS A 149
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.25A 2ozrF-3lmcA:
7.0		 2ozrF-3lmcA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		5 / 9 HIS A 149
GLU A 150
HIS A 153
HIS A 159
LEU A 176
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
None
 0.72A 3hy7B-3lmcA:
13.2		 3hy7B-3lmcA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		4 / 5 HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.24A 3kecA-3lmcA:
7.2		 3kecA-3lmcA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		4 / 5 HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.25A 3likA-3lmcA:
8.2		 3likA-3lmcA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIL_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		4 / 4 HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.26A 3lilA-3lmcA:
8.3		 3lilA-3lmcA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		4 / 5 HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.25A 3ljgA-3lmcA:
5.8		 3ljgA-3lmcA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		4 / 5 HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.22A 3lkaA-3lmcA:
8.1		 3lkaA-3lmcA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		5 / 12 GLY A 109
ILE A 119
ALA A  53
VAL A 107
GLU A 175
 None
 1.09A 3nvkI-3lmcA:
undetectable		 3nvkI-3lmcA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		4 / 6 HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.34A 4a7bA-3lmcA:
6.7		 4a7bA-3lmcA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5J_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		4 / 4 HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.23A 5n5jA-3lmcA:
8.2		 5n5jA-3lmcA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		4 / 5 HIS A 149
GLU A 150
HIS A 153
HIS A 159
 ZN  A 212 (-3.4A)
ZN  A 212 ( 4.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.3A)
 0.22A 5n5kA-3lmcA:
8.3		 5n5kA-3lmcA:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_N_CUN603_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		3 / 3 HIS A 159
HIS A 153
HIS A 149
 ZN  A 212 (-3.3A)
ZN  A 212 (-3.4A)
ZN  A 212 (-3.4A)
 0.68A 5x1fN-3lmcA:
undetectable		 5x1fN-3lmcA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 3lmc PEPTIDASE,
ZINC-DEPENDENT
(Methanocorpuscul
um
labreanum) 		4 / 7 GLY A 156
PHE A 155
HIS A 153
LYS A  90
 None
None
ZN  A 212 (-3.4A)
None
 1.03A 6hu9S-3lmcA:
undetectable
6hu9q-3lmcA:
undetectable		 6hu9S-3lmcA:
19.59
6hu9q-3lmcA:
20.57