SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lme'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 3lme POSSIBLE TRANSLATION
INITIATION INHIBITOR
(Rhodopseudomonas
palustris) 		4 / 4 ILE A  32
MET A  85
VAL A 100
GLY A  48
 None
 1.26A 1e06B-3lmeA:
undetectable		 1e06B-3lmeA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 3lme POSSIBLE TRANSLATION
INITIATION INHIBITOR
(Rhodopseudomonas
palustris) 		5 / 9 ALA A  91
GLY A  48
ILE A  31
PRO A  41
THR A  40
 None
 1.10A 3el4B-3lmeA:
undetectable		 3el4B-3lmeA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 3lme POSSIBLE TRANSLATION
INITIATION INHIBITOR
(Rhodopseudomonas
palustris) 		5 / 11 ALA A  91
GLY A  48
ILE A  31
PRO A  41
THR A  40
 None
 0.91A 3spkA-3lmeA:
undetectable		 3spkA-3lmeA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 3lme POSSIBLE TRANSLATION
INITIATION INHIBITOR
(Rhodopseudomonas
palustris) 		5 / 11 ALA A  91
ILE A  57
ILE A  31
PRO A  41
THR A  40
 None
 0.83A 3spkA-3lmeA:
undetectable		 3spkA-3lmeA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 3lme POSSIBLE TRANSLATION
INITIATION INHIBITOR
(Rhodopseudomonas
palustris) 		5 / 9 ALA A  91
GLY A  48
ILE A  31
PRO A  41
THR A  40
 None
 0.91A 3spkA-3lmeA:
undetectable		 3spkA-3lmeA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 3lme POSSIBLE TRANSLATION
INITIATION INHIBITOR
(Rhodopseudomonas
palustris) 		5 / 12 ALA A  91
ILE A  57
ILE A  31
PRO A  41
THR A  40
 None
 0.93A 3spkB-3lmeA:
undetectable		 3spkB-3lmeA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 3lme POSSIBLE TRANSLATION
INITIATION INHIBITOR
(Rhodopseudomonas
palustris) 		5 / 9 ALA A  91
ILE A  57
GLY A  48
ILE A  31
PRO A  41
 None
 0.98A 3u7sA-3lmeA:
undetectable		 3u7sA-3lmeA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 3lme POSSIBLE TRANSLATION
INITIATION INHIBITOR
(Rhodopseudomonas
palustris) 		3 / 3 ASP A  83
ARG A  79
ASP A  64
 None
 0.77A 4fp9A-3lmeA:
undetectable		 4fp9A-3lmeA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 3lme POSSIBLE TRANSLATION
INITIATION INHIBITOR
(Rhodopseudomonas
palustris) 		5 / 10 ALA A  91
GLY A  48
ILE A  31
PRO A  41
THR A  40
 None
 1.05A 4njuB-3lmeA:
undetectable		 4njuB-3lmeA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 3lme POSSIBLE TRANSLATION
INITIATION INHIBITOR
(Rhodopseudomonas
palustris) 		5 / 10 ALA A  91
GLY A  48
ILE A  31
PRO A  41
THR A  40
 None
 1.04A 4njuD-3lmeA:
undetectable		 4njuD-3lmeA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 3lme POSSIBLE TRANSLATION
INITIATION INHIBITOR
(Rhodopseudomonas
palustris) 		5 / 8 VAL A 134
VAL A 106
PHE A 105
MET A  81
ILE A 148
 SO4  A  15 (-3.8A)
None
None
None
None
 1.30A 5y9mA-3lmeA:
undetectable		 5y9mA-3lmeA:
19.85