SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lmk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		4 / 8 ILE A  37
VAL A 191
GLY A 145
LEU A 437
 None
 0.95A 1dzmA-3lmkA:
undetectable		 1dzmA-3lmkA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		5 / 12 LEU A  73
LEU A  76
HIS A 391
ILE A  95
PHE A 358
 None
 1.36A 1fmlA-3lmkA:
undetectable		 1fmlA-3lmkA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		4 / 7 LEU A  40
VAL A 146
GLY A  38
ILE A 113
 None
 0.78A 1p2yA-3lmkA:
undetectable		 1p2yA-3lmkA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		4 / 8 ASP A 394
SER A  42
ARG A  61
ALA A  71
 None
 1.08A 1rqpC-3lmkA:
3.3		 1rqpC-3lmkA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		4 / 8 ASP A 394
SER A  42
ARG A  61
ALA A  71
 None
 1.04A 1rqpA-3lmkA:
2.7		 1rqpA-3lmkA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_B_EDTB1511_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		4 / 8 TYR A  64
ARG A  61
TYR A 223
THR A 175
 GLU  A 506 (-4.6A)
None
GLU  A 506 (-3.4A)
GLU  A 506 (-3.0A)
 1.46A 1zlqB-3lmkA:
1.3		 1zlqB-3lmkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		4 / 8 PHE A 337
VAL A 334
ILE A 404
GLY A 398
 None
 0.91A 2gssA-3lmkA:
undetectable		 2gssA-3lmkA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		4 / 8 PHE A 337
VAL A 334
ILE A 404
GLY A 398
 None
 0.91A 2gssB-3lmkA:
undetectable		 2gssB-3lmkA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		3 / 3 ASN A  88
ILE A  35
MET A 429
 None
 0.66A 2h42C-3lmkA:
undetectable		 2h42C-3lmkA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		3 / 3 ASP A  97
ARG A  96
ARG A  26
 None
 1.08A 2j9dA-3lmkA:
undetectable
2j9dC-3lmkA:
undetectable		 2j9dA-3lmkA:
12.20
2j9dC-3lmkA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		4 / 8 ASP A 394
SER A  42
ARG A  61
ALA A  71
 None
 1.01A 2v7uA-3lmkA:
2.7		 2v7uA-3lmkA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		4 / 7 GLY A 398
GLN A 393
VAL A 334
ILE A 404
 None
 0.82A 3fi0P-3lmkA:
undetectable		 3fi0P-3lmkA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		4 / 7 PHE A 337
VAL A 334
ILE A 404
GLY A 398
 None
 1.00A 3gssA-3lmkA:
undetectable		 3gssA-3lmkA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		4 / 7 PHE A 337
VAL A 334
ILE A 404
GLY A 398
 None
 1.00A 3gssB-3lmkA:
undetectable		 3gssB-3lmkA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		5 / 12 GLU A 279
GLY A 280
ASP A 305
VAL A 192
GLY A 150
 None
None
GLU  A 506 (-2.7A)
None
None
 1.11A 3k13A-3lmkA:
undetectable		 3k13A-3lmkA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		5 / 12 GLU A 279
GLY A 280
ASP A 305
VAL A 192
GLY A 150
 None
None
GLU  A 506 (-2.7A)
None
None
 1.13A 3k13B-3lmkA:
undetectable		 3k13B-3lmkA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		5 / 12 GLU A 279
GLY A 280
ASP A 305
VAL A 192
GLY A 150
 None
None
GLU  A 506 (-2.7A)
None
None
 1.14A 3k13C-3lmkA:
undetectable		 3k13C-3lmkA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		4 / 8 PHE A 337
VAL A 334
ILE A 404
GLY A 398
 None
 0.95A 3n9jA-3lmkA:
undetectable		 3n9jA-3lmkA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		5 / 12 TYR A 481
GLU A 320
ALA A 321
GLY A 323
LEU A 301
 None
 1.14A 3ou6C-3lmkA:
undetectable		 3ou6C-3lmkA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		5 / 12 TYR A 481
GLU A 320
ALA A 321
GLY A 323
LEU A 301
 None
 1.15A 3ou6D-3lmkA:
undetectable		 3ou6D-3lmkA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROZ_A_NCAA266_0
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		4 / 6 ASP A 305
LEU A 329
ALA A 171
THR A 175
 GLU  A 506 (-2.7A)
None
None
GLU  A 506 (-3.0A)
 1.12A 3rozA-3lmkA:
4.8		 3rozA-3lmkA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		5 / 12 ARG A 200
GLY A 303
SER A 304
ALA A 199
SER A 235
 None
 1.22A 3sueD-3lmkA:
undetectable		 3sueD-3lmkA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		5 / 12 SER A 215
VAL A 214
GLN A 198
SER A 304
PHE A 231
 None
 1.32A 4c49D-3lmkA:
undetectable		 4c49D-3lmkA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_B_C2FB302_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		5 / 12 PHE A 446
ASP A 452
ASP A 488
GLY A 464
SER A 462
 None
 1.50A 4djeB-3lmkA:
3.1		 4djeB-3lmkA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		5 / 11 ASP A 178
ALA A 196
GLY A 224
SER A 176
ASP A 233
 None
 1.24A 4mm9A-3lmkA:
undetectable		 4mm9A-3lmkA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		5 / 9 LEU A  76
GLY A  38
ALA A  39
ILE A 170
THR A  75
 None
 1.13A 4njtD-3lmkA:
undetectable		 4njtD-3lmkA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		3 / 3 ASP A 309
ASN A 483
SER A 304
 None
 0.70A 4obwA-3lmkA:
2.8		 4obwA-3lmkA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		5 / 11 GLY A 224
ASP A 195
ILE A 327
GLY A 306
VAL A 274
 None
None
None
GLU  A 506 ( 3.7A)
None
 0.97A 4qgiA-3lmkA:
undetectable		 4qgiA-3lmkA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		4 / 4 PHE A 277
ASP A 305
GLY A 227
SER A 304
 None
GLU  A 506 (-2.7A)
None
None
 1.39A 4xp9C-3lmkA:
undetectable		 4xp9C-3lmkA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		4 / 8 TYR A  64
ARG A  61
TYR A 223
THR A 175
 GLU  A 506 (-4.6A)
None
GLU  A 506 (-3.4A)
GLU  A 506 (-3.0A)
 1.47A 5l8dA-3lmkA:
1.7		 5l8dA-3lmkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		4 / 8 TYR A  64
ARG A  61
TYR A 223
THR A 175
 GLU  A 506 (-4.6A)
None
GLU  A 506 (-3.4A)
GLU  A 506 (-3.0A)
 1.47A 5mwuA-3lmkA:
1.7		 5mwuA-3lmkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		4 / 8 ILE A  37
ALA A  39
LEU A  73
ILE A  36
 None
 0.77A 5uihA-3lmkA:
3.3		 5uihA-3lmkA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 3lmk METABOTROPIC
GLUTAMATE RECEPTOR 5
(Homo
sapiens) 		5 / 10 GLY A 285
LEU A 286
THR A 314
VAL A 313
ALA A 321
 None
 1.12A 6czmA-3lmkA:
undetectable
6czmC-3lmkA:
undetectable		 6czmA-3lmkA:
21.04
6czmC-3lmkA:
21.04