SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		3 / 3 ALA A 281
VAL A 276
TRP A 275
 None
 0.80A 1kqeA-3lmlA:
undetectable
1kqeE-3lmlA:
undetectable		 1kqeA-3lmlA:
2.90
1kqeE-3lmlA:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		3 / 3 ALA A 281
VAL A 276
TRP A 275
 None
 0.78A 1kqeB-3lmlA:
undetectable
1kqeD-3lmlA:
undetectable		 1kqeB-3lmlA:
2.90
1kqeD-3lmlA:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		3 / 3 TRP A 275
ALA A 281
VAL A 276
 None
 0.79A 1kqeB-3lmlA:
undetectable
1kqeD-3lmlA:
undetectable		 1kqeB-3lmlA:
2.90
1kqeD-3lmlA:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		3 / 3 TRP A 275
ALA A 281
VAL A 276
 None
 0.78A 1kqeA-3lmlA:
undetectable
1kqeE-3lmlA:
undetectable		 1kqeA-3lmlA:
2.90
1kqeE-3lmlA:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		5 / 12 ILE A 393
LEU A 423
PHE A 430
LEU A 453
ILE A 383
 None
 1.01A 1rb2B-3lmlA:
undetectable		 1rb2B-3lmlA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		6 / 10 LEU A 140
ALA A 110
GLY A 182
GLY A 183
ILE A 115
ILE A 120
 None
 1.18A 1sdvA-3lmlA:
undetectable		 1sdvA-3lmlA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		5 / 11 LEU A 102
VAL A 150
GLY A 151
ALA A 153
LEU A 156
 None
 1.26A 2bxgA-3lmlA:
undetectable		 2bxgA-3lmlA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		4 / 5 VAL A 136
VAL A 124
THR A 152
THR A 138
 None
 1.27A 3bjwG-3lmlA:
undetectable		 3bjwG-3lmlA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		4 / 5 VAL A 136
VAL A 124
THR A 152
THR A 138
 None
 1.27A 3bjwD-3lmlA:
undetectable		 3bjwD-3lmlA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGX_B_SALB104_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		5 / 9 ARG A  29
MET A 285
ILE A 357
ILE A 436
GLN A 434
 None
 1.39A 3hgxB-3lmlA:
1.0		 3hgxB-3lmlA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		5 / 9 PHE A 392
ILE A 369
PHE A  22
ALA A 399
VAL A 432
 None
 1.25A 3me6C-3lmlA:
undetectable		 3me6C-3lmlA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		5 / 9 PHE A 392
ILE A 369
PHE A  22
ALA A 399
VAL A 432
 None
 1.28A 3me6D-3lmlA:
undetectable		 3me6D-3lmlA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		5 / 12 ALA A  43
PHE A  74
ARG A  78
ILE A  55
LEU A  40
 None
 1.15A 3nrrA-3lmlA:
undetectable		 3nrrA-3lmlA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		5 / 12 ALA A  43
PHE A  74
ARG A  78
ILE A  55
LEU A  40
 None
 1.17A 3nrrB-3lmlA:
undetectable		 3nrrB-3lmlA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		3 / 3 ASN A 289
ALA A 283
ARG A 356
 None
 0.54A 3tj7C-3lmlA:
undetectable
3tj7D-3lmlA:
undetectable		 3tj7C-3lmlA:
17.47
3tj7D-3lmlA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF512_1
(HEMOLYTIC LECTIN
CEL-III)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		4 / 6 THR A 365
ASN A 362
GLY A 360
ILE A 410
 None
 1.00A 3w9tF-3lmlA:
undetectable		 3w9tF-3lmlA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		5 / 11 ALA A  26
LEU A 404
ASN A 368
VAL A 432
ILE A 369
 None
 1.43A 4claA-3lmlA:
undetectable		 4claA-3lmlA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		5 / 12 ILE A 393
LEU A 423
PHE A 430
LEU A 453
ILE A 383
 None
 0.99A 4fhbA-3lmlA:
undetectable		 4fhbA-3lmlA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		3 / 3 ASP A 323
ARG A 325
ASP A 299
 None
 0.88A 4fp9C-3lmlA:
undetectable		 4fp9C-3lmlA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		5 / 10 LEU A 140
ALA A 110
GLY A 183
ILE A 115
ILE A 120
 None
 1.10A 4njuD-3lmlA:
undetectable		 4njuD-3lmlA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		4 / 5 LEU A 320
ASP A 334
GLU A 317
VAL A 242
 None
 1.31A 4nkvA-3lmlA:
undetectable		 4nkvA-3lmlA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		4 / 7 THR A  80
ASN A 289
GLN A 333
GLU A 332
 None
 1.13A 5tudA-3lmlA:
undetectable		 5tudA-3lmlA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6M_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		5 / 11 ILE A 393
LEU A 423
PHE A 430
LEU A 453
ILE A 383
 None
 1.02A 5z6mA-3lmlA:
undetectable		 5z6mA-3lmlA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		4 / 8 ARG A 303
THR A 301
PRO A 302
ILE A 266
 None
 1.13A 6a4iA-3lmlA:
undetectable		 6a4iA-3lmlA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		5 / 12 ALA A 277
ALA A 274
ALA A 279
ILE A  55
LEU A  42
 None
 0.96A 6a5yD-3lmlA:
undetectable		 6a5yD-3lmlA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3lml LIN1278 PROTEIN
(Listeria
innocua) 		4 / 5 ARG A 366
ARG A 367
ASN A 368
ASP A 371
 None
 1.40A 6dwjB-3lmlA:
undetectable
6dwjD-3lmlA:
undetectable		 6dwjB-3lmlA:
22.34
6dwjD-3lmlA:
22.34