SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lms'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 3lms CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 5 HIS A1501
ALA A 250
SER A 207
HIS A 242
 None
GLY  A 501 ( 4.9A)
None
None
 1.31A 1errA-3lmsA:
undetectable
1errB-3lmsA:
undetectable		 1errA-3lmsA:
19.02
1errB-3lmsA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3lms CARBOXYPEPTIDASE B2
(Homo
sapiens) 		5 / 11 HIS A 196
ALA A 250
HIS A 201
THR A 268
SER A 207
 ZN  A 309 (-3.2A)
GLY  A 501 ( 4.9A)
None
GLY  A 501 ( 4.6A)
None
 1.08A 1gtnM-3lmsA:
undetectable
1gtnN-3lmsA:
undetectable		 1gtnM-3lmsA:
15.19
1gtnN-3lmsA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 3lms CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 8 ILE A  25
THR A  26
PRO A 109
LEU A  50
 None
 0.70A 1hmyA-3lmsA:
undetectable		 1hmyA-3lmsA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 3lms CARBOXYPEPTIDASE B2
(Homo
sapiens) 		3 / 3 ASP A 255
HIS A 196
ASP A  65
 None
ZN  A 309 (-3.2A)
None
 0.66A 1nw5A-3lmsA:
undetectable		 1nw5A-3lmsA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_B_NCAB1246_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3lms CARBOXYPEPTIDASE B2
(Homo
sapiens) 		5 / 7 GLY A 278
SER A 199
SER A 197
PHE A 279
GLU A 270
 None
None
None
None
GLY  A 501 ( 4.6A)
 1.37A 2c8aB-3lmsA:
undetectable		 2c8aB-3lmsA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_C_NCAC1252_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 3lms CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 6 SER A 199
SER A 197
PHE A 279
GLU A 270
 None
None
None
GLY  A 501 ( 4.6A)
 1.41A 2c8aC-3lmsA:
undetectable		 2c8aC-3lmsA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 3lms CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 5 SER A 197
LEU A 280
GLY A 278
ARG A 124
 None
GOL  A 505 (-4.6A)
None
GOL  A 505 (-3.9A)
 0.97A 2j2pA-3lmsA:
undetectable
2j2pB-3lmsA:
undetectable		 2j2pA-3lmsA:
21.62
2j2pB-3lmsA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 3lms CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 6 GLU A 292
MET A 195
PHE A  78
ILE A  74
 None
 1.18A 2w98B-3lmsA:
undetectable		 2w98B-3lmsA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1162_1
(ALLERGEN ARG R 1)		 3lms CARBOXYPEPTIDASE B2
(Homo
sapiens) 		3 / 3 GLU A 270
HIS A  69
GLU A  72
 GLY  A 501 ( 4.6A)
ZN  A 309 ( 3.1A)
ZN  A 309 (-2.0A)
 0.71A 2x45B-3lmsA:
undetectable		 2x45B-3lmsA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1162_1
(ALLERGEN ARG R 1)		 3lms CARBOXYPEPTIDASE B2
(Homo
sapiens) 		3 / 3 GLU A 270
HIS A  69
GLU A  72
 GLY  A 501 ( 4.6A)
ZN  A 309 ( 3.1A)
ZN  A 309 (-2.0A)
 0.74A 2x45C-3lmsA:
undetectable		 2x45C-3lmsA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 3lms CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 5 ILE A  86
ARG A 101
THR A  97
GLU A  56
 None
 1.34A 3ny4A-3lmsA:
undetectable		 3ny4A-3lmsA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 3lms CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 7 ILE A  62
MET A  32
LYS A  55
GLY A  54
 None
 1.24A 3sj0X-3lmsA:
undetectable		 3sj0X-3lmsA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 3lms CARBOXYPEPTIDASE B2
(Homo
sapiens) 		3 / 3 TRP A  73
VAL A 113
TRP A 120
 None
 1.12A 3zq8A-3lmsA:
undetectable
3zq8B-3lmsA:
undetectable		 3zq8A-3lmsA:
3.62
3zq8B-3lmsA:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 3lms CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 6 ILE A  86
TYR A  96
PHE A  89
THR A 233
 None
 1.11A 5g08A-3lmsA:
undetectable		 5g08A-3lmsA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3lms CARBOXYPEPTIDASE B2
(Homo
sapiens) 		5 / 10 LEU A 183
ILE A 189
PHE A 182
ALA A  61
VAL A  49
 None
 1.38A 5m0oA-3lmsA:
undetectable		 5m0oA-3lmsA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 3lms CARBOXYPEPTIDASE B2
(Homo
sapiens) 		4 / 7 SER A 207
ILE A 202
GLU A 270
ASP A 255
 None
None
GLY  A 501 ( 4.6A)
None
 0.91A 5n5dA-3lmsA:
undetectable		 5n5dA-3lmsA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 3lms CARBOXYPEPTIDASE B2
(Homo
sapiens) 		3 / 3 LYS A 212
HIS A 216
HIS A 242
 None
 1.04A 5oexA-3lmsA:
undetectable		 5oexA-3lmsA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 3lms CARBOXYPEPTIDASE B2
(Homo
sapiens) 		3 / 3 LYS A 212
HIS A 216
HIS A 242
 None
 1.13A 5oexB-3lmsA:
undetectable		 5oexB-3lmsA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 3lms CARBOXYPEPTIDASE B2
(Homo
sapiens) 		3 / 3 LYS A 212
HIS A 216
HIS A 242
 None
 1.12A 5oexC-3lmsA:
undetectable		 5oexC-3lmsA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 3lms CARBOXYPEPTIDASE B2
(Homo
sapiens) 		3 / 3 LYS A 212
HIS A 216
HIS A 242
 None
 1.09A 5oexD-3lmsA:
undetectable		 5oexD-3lmsA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_1
(CYTOCHROME P450 3A4)		 3lms CARBOXYPEPTIDASE B2
(Homo
sapiens) 		5 / 12 ARG A 291
LEU A 100
PHE A 105
ILE A 300
ALA A 296
 None
 1.09A 5vc0A-3lmsA:
undetectable		 5vc0A-3lmsA:
20.64