SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lnl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		5 / 12 ILE A 267
ASP A 365
VAL A 112
LEU A 116
ILE A 328
 None
 0.93A 1df7A-3lnlA:
undetectable		 1df7A-3lnlA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		4 / 8 ASP A 106
HIS A  68
HIS A  69
HIS A 102
 ZN  A 401 ( 2.0A)
ZN  A 401 (-3.4A)
ZN  A 402 (-3.5A)
B3P  A 371 ( 4.8A)
 1.01A 1ei6D-3lnlA:
undetectable		 1ei6D-3lnlA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		5 / 12 HIS A 330
GLY A 287
GLY A 308
VAL A 107
VAL A 112
 ZN  A 402 (-3.4A)
None
None
None
None
 1.19A 1n2xA-3lnlA:
undetectable		 1n2xA-3lnlA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R55_A_097A518_1
(ADAM 33)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		5 / 10 ALA A  23
THR A 103
HIS A  69
GLU A 333
HIS A 330
 None
B3P  A 371 ( 4.8A)
ZN  A 402 (-3.5A)
ZN  A 401 ( 2.4A)
ZN  A 402 (-3.4A)
 1.25A 1r55A-3lnlA:
undetectable		 1r55A-3lnlA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		5 / 12 ILE A 267
ASP A 365
SER A 289
LEU A 116
ILE A 328
 None
 0.97A 2drcA-3lnlA:
undetectable		 2drcA-3lnlA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		4 / 8 ASP A 106
LEU A 242
GLY A 290
HIS A 102
 ZN  A 401 ( 2.0A)
B3P  A 371 (-4.5A)
B3P  A 371 ( 4.6A)
B3P  A 371 ( 4.8A)
 1.01A 3af0A-3lnlA:
undetectable		 3af0A-3lnlA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		5 / 11 VAL A 304
ALA A 297
ILE A 128
ILE A 125
ILE A 283
 None
 1.01A 3clbA-3lnlA:
undetectable		 3clbA-3lnlA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		5 / 10 VAL A 304
ALA A 297
ILE A 128
ILE A 125
ILE A 283
 None
 1.03A 3clbD-3lnlA:
undetectable		 3clbD-3lnlA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		5 / 12 ILE A 267
ASP A 365
SER A 289
LEU A 116
ILE A 328
 None
 0.96A 3drcA-3lnlA:
undetectable		 3drcA-3lnlA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DTU_C_DXCC576_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		4 / 8 ALA A 315
ALA A 318
ILE A 310
THR A 307
 None
 0.76A 3dtuC-3lnlA:
undetectable
3dtuD-3lnlA:
undetectable		 3dtuC-3lnlA:
21.91
3dtuD-3lnlA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		5 / 12 GLY A 243
GLY A 241
PHE A 305
ASP A 106
ILE A 286
 None
None
None
ZN  A 401 ( 2.0A)
None
 0.92A 3elwA-3lnlA:
undetectable		 3elwA-3lnlA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		3 / 3 ILE A 310
PHE A 305
HIS A 330
 None
None
ZN  A 402 (-3.4A)
 0.71A 3h0aA-3lnlA:
undetectable		 3h0aA-3lnlA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		5 / 10 VAL A 304
ALA A 297
ILE A 128
ILE A 125
ILE A 283
 None
 1.03A 3hbbA-3lnlA:
undetectable		 3hbbA-3lnlA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		5 / 11 VAL A 304
ALA A 297
ILE A 128
ILE A 125
ILE A 283
 None
 1.01A 3hbbC-3lnlA:
undetectable		 3hbbC-3lnlA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		5 / 10 VAL A 304
ALA A 297
ILE A 128
ILE A 125
ILE A 283
 None
 0.99A 3hbbD-3lnlA:
undetectable		 3hbbD-3lnlA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		4 / 4 GLY A  61
TYR A  62
GLY A  42
ASP A 356
 None
 0.79A 3kl3A-3lnlA:
undetectable		 3kl3A-3lnlA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		3 / 3 HIS A  69
HIS A  68
HIS A 102
 ZN  A 402 (-3.5A)
ZN  A 401 (-3.4A)
B3P  A 371 ( 4.8A)
 0.57A 3mihA-3lnlA:
undetectable		 3mihA-3lnlA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA357_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		3 / 3 HIS A 102
HIS A  69
HIS A  68
 B3P  A 371 ( 4.8A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.4A)
 0.64A 3mihA-3lnlA:
undetectable		 3mihA-3lnlA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		5 / 9 ILE A 326
ILE A 328
VAL A 304
ILE A 285
ILE A 283
 None
 1.21A 3p4wB-3lnlA:
undetectable		 3p4wB-3lnlA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		5 / 10 ILE A 326
ILE A 328
VAL A 304
ILE A 285
ILE A 283
 None
 1.21A 3p4wD-3lnlA:
undetectable		 3p4wD-3lnlA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		5 / 10 ILE A 326
ILE A 328
VAL A 304
ILE A 285
ILE A 283
 None
 1.21A 3p4wE-3lnlA:
undetectable		 3p4wE-3lnlA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD305_0
(GLUTATHIONE
TRANSFERASE GTE1)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		4 / 4 ILE A 328
LEU A 265
LYS A 262
ASN A 329
 None
 1.10A 4g19D-3lnlA:
undetectable		 4g19D-3lnlA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		5 / 10 TYR A  84
ILE A  87
ILE A  88
ILE A  65
ILE A  96
 None
 1.07A 5murE-3lnlA:
undetectable		 5murE-3lnlA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		5 / 12 ILE A 285
VAL A 244
GLY A 243
ASP A 106
GLY A 111
 None
None
None
ZN  A 401 ( 2.0A)
None
 1.06A 5nnaD-3lnlA:
2.4		 5nnaD-3lnlA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 3lnl UPF0135 PROTEIN
SA1388
(Staphylococcus
aureus) 		4 / 8 ILE A 283
ALA A 302
LEU A 325
ILE A 285
 None
 0.84A 5uihA-3lnlA:
undetectable		 5uihA-3lnlA:
13.86