SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lnn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 3lnn MEMBRANE FUSION
PROTEIN (MFP) HEAVY
METAL CATION EFFLUX
ZNEB (CZCB-LIKE)
(Cupriavidus
metallidurans) 		4 / 7 VAL A 208
VAL A 182
ARG A 269
LEU A  75
 None
 0.97A 1iepB-3lnnA:
2.2		 1iepB-3lnnA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 3lnn MEMBRANE FUSION
PROTEIN (MFP) HEAVY
METAL CATION EFFLUX
ZNEB (CZCB-LIKE)
(Cupriavidus
metallidurans) 		5 / 12 SER A  70
LEU A 184
ASN A  72
THR A 162
PRO A  62
 None
 1.28A 3dcjA-3lnnA:
undetectable
3dcjB-3lnnA:
undetectable		 3dcjA-3lnnA:
23.58
3dcjB-3lnnA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_2
(GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 3lnn MEMBRANE FUSION
PROTEIN (MFP) HEAVY
METAL CATION EFFLUX
ZNEB (CZCB-LIKE)
(Cupriavidus
metallidurans) 		5 / 9 ALA A  55
ILE A 177
THR A 211
PHE A 209
GLU A  51
 None
 1.39A 3qelD-3lnnA:
undetectable		 3qelD-3lnnA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 3lnn MEMBRANE FUSION
PROTEIN (MFP) HEAVY
METAL CATION EFFLUX
ZNEB (CZCB-LIKE)
(Cupriavidus
metallidurans) 		4 / 7 HIS A 221
GLU A 329
HIS A 285
VAL A 289
 ZN  A 360 (-3.3A)
ZN  A 360 (-2.3A)
ZN  A 360 (-3.5A)
None
 1.12A 4hvrA-3lnnA:
undetectable		 4hvrA-3lnnA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 3lnn MEMBRANE FUSION
PROTEIN (MFP) HEAVY
METAL CATION EFFLUX
ZNEB (CZCB-LIKE)
(Cupriavidus
metallidurans) 		3 / 3 LYS A 158
LEU A 155
ALA A 157
 None
 0.69A 4ikiA-3lnnA:
undetectable		 4ikiA-3lnnA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM0_A_CP6A201_1
(DIHYDROFOLATE
REDUCTASE)		 3lnn MEMBRANE FUSION
PROTEIN (MFP) HEAVY
METAL CATION EFFLUX
ZNEB (CZCB-LIKE)
(Cupriavidus
metallidurans) 		5 / 10 ILE A  88
ALA A 172
LEU A 184
ILE A  68
THR A 162
 None
 1.25A 4km0A-3lnnA:
undetectable		 4km0A-3lnnA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3lnn MEMBRANE FUSION
PROTEIN (MFP) HEAVY
METAL CATION EFFLUX
ZNEB (CZCB-LIKE)
(Cupriavidus
metallidurans) 		5 / 12 ASN A  45
PHE A 280
THR A 229
TYR A 223
VAL A 259
 None
 1.29A 5d0yA-3lnnA:
undetectable		 5d0yA-3lnnA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_B_FOLB201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3lnn MEMBRANE FUSION
PROTEIN (MFP) HEAVY
METAL CATION EFFLUX
ZNEB (CZCB-LIKE)
(Cupriavidus
metallidurans) 		5 / 12 ASN A  45
PHE A 280
THR A 229
TYR A 223
VAL A 259
 None
 1.29A 5d0yB-3lnnA:
1.1		 5d0yB-3lnnA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 3lnn MEMBRANE FUSION
PROTEIN (MFP) HEAVY
METAL CATION EFFLUX
ZNEB (CZCB-LIKE)
(Cupriavidus
metallidurans) 		4 / 4 LYS A 158
LEU A 155
ALA A 157
LEU A 152
 None
 1.30A 6gnrA-3lnnA:
undetectable		 6gnrA-3lnnA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 3lnn MEMBRANE FUSION
PROTEIN (MFP) HEAVY
METAL CATION EFFLUX
ZNEB (CZCB-LIKE)
(Cupriavidus
metallidurans) 		4 / 4 LYS A 158
LEU A 155
ALA A 157
LEU A 152
 None
 1.29A 6gnrB-3lnnA:
undetectable		 6gnrB-3lnnA:
19.02