SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lo0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 3lo0 INORGANIC
PYROPHOSPHATASE
(Ehrlichia
chaffeensis) 		4 / 8 ASN A 120
GLN A 116
ASP A 115
THR A 111
 None
 1.11A 1ig3A-3lo0A:
undetectable
1ig3B-3lo0A:
undetectable		 1ig3A-3lo0A:
22.93
1ig3B-3lo0A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 3lo0 INORGANIC
PYROPHOSPHATASE
(Ehrlichia
chaffeensis) 		3 / 3 ASP A  66
GLU A  21
TYR A 142
 None
 0.77A 1wsvA-3lo0A:
undetectable		 1wsvA-3lo0A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 3lo0 INORGANIC
PYROPHOSPHATASE
(Ehrlichia
chaffeensis) 		5 / 11 VAL A  18
GLY A  57
ILE A  22
SER A  23
PRO A  79
 None
 1.30A 3bjwB-3lo0A:
undetectable		 3bjwB-3lo0A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 3lo0 INORGANIC
PYROPHOSPHATASE
(Ehrlichia
chaffeensis) 		5 / 11 VAL A  18
GLY A  57
ILE A  22
SER A  23
PRO A  79
 None
 1.30A 3bjwH-3lo0A:
undetectable		 3bjwH-3lo0A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3lo0 INORGANIC
PYROPHOSPHATASE
(Ehrlichia
chaffeensis) 		4 / 8 ILE A 166
PRO A  13
VAL A  93
GLY A  92
 None
 0.91A 3em0B-3lo0A:
undetectable		 3em0B-3lo0A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 3lo0 INORGANIC
PYROPHOSPHATASE
(Ehrlichia
chaffeensis) 		5 / 10 GLY A  92
LEU A 165
PRO A  13
VAL A  12
ILE A  16
 None
 1.01A 3em4V-3lo0A:
undetectable		 3em4V-3lo0A:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3lo0 INORGANIC
PYROPHOSPHATASE
(Ehrlichia
chaffeensis) 		5 / 11 VAL A  29
PHE A 138
PHE A 139
GLY A  57
ILE A  20
 None
 1.34A 3owxA-3lo0A:
undetectable
3owxB-3lo0A:
undetectable		 3owxA-3lo0A:
24.03
3owxB-3lo0A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 3lo0 INORGANIC
PYROPHOSPHATASE
(Ehrlichia
chaffeensis) 		4 / 5 LEU A  73
ALA A  75
PHE A 131
ASN A  25
 None
 1.48A 3uq6A-3lo0A:
undetectable		 3uq6A-3lo0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 3lo0 INORGANIC
PYROPHOSPHATASE
(Ehrlichia
chaffeensis) 		3 / 3 ARG A  77
PHE A  78
PRO A  79
 None
 0.61A 3zoaB-3lo0A:
undetectable		 3zoaB-3lo0A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA603_1
(CHITINASE)		 3lo0 INORGANIC
PYROPHOSPHATASE
(Ehrlichia
chaffeensis) 		4 / 8 GLY A  57
GLU A  21
ASP A  43
ARG A  44
 None
None
None
SO4  A 173 ( 4.8A)
 1.06A 5gqbA-3lo0A:
undetectable		 5gqbA-3lo0A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3lo0 INORGANIC
PYROPHOSPHATASE
(Ehrlichia
chaffeensis) 		5 / 12 ASP A  34
PRO A  69
GLY A  57
GLU A  21
TYR A  56
 None
None
None
None
SO4  A 173 (-4.4A)
 1.14A 5hfjD-3lo0A:
undetectable		 5hfjD-3lo0A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3lo0 INORGANIC
PYROPHOSPHATASE
(Ehrlichia
chaffeensis) 		5 / 12 ASP A  34
PRO A  69
GLY A  57
GLU A  21
TYR A  56
 None
None
None
None
SO4  A 173 (-4.4A)
 1.14A 5hfjF-3lo0A:
undetectable		 5hfjF-3lo0A:
21.40