SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lop'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
4 / 8 GLU A 328
ARG A 331
ARG A 332
LEU A 349
None
0.83A 1cmaA-3lopA:
undetectable
1cmaB-3lopA:
undetectable
1cmaA-3lopA:
15.31
1cmaB-3lopA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
5 / 10 GLU A 328
ARG A 331
ARG A 332
LEU A 349
GLY A 356
None
0.92A 1cmcA-3lopA:
undetectable
1cmcB-3lopA:
undetectable
1cmcA-3lopA:
15.31
1cmcB-3lopA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
5 / 10 GLU A 328
ARG A 331
ARG A 332
LEU A 349
GLY A 357
None
None
None
None
EDO  A 404 ( 4.6A)
1.09A 1cmcA-3lopA:
undetectable
1cmcB-3lopA:
undetectable
1cmcA-3lopA:
15.31
1cmcB-3lopA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQU_A_EQIA329_0
(PROTEIN (ESTRADIOL
17
BETA-DEHYDROGENASE
1))
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
5 / 10 VAL A 384
LEU A 282
GLY A 288
PRO A 287
TYR A 372
None
None
None
None
EDO  A 404 (-3.4A)
1.44A 1equA-3lopA:
undetectable
1equA-3lopA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
5 / 12 VAL A 384
LEU A 282
GLY A 288
PRO A 287
TYR A 372
None
None
None
None
EDO  A 404 (-3.4A)
1.46A 1fdsA-3lopA:
5.5
1fdsA-3lopA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
5 / 11 MET A 142
SER A 141
ILE A  88
ALA A 118
LEU A 119
None
1.45A 1jb0B-3lopA:
undetectable
1jb0B-3lopA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_A_ID2A1_0
(THYMIDINE KINASE)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
5 / 12 GLU A 328
ILE A  72
ILE A  77
ALA A 323
TYR A  62
None
1.37A 1ki7A-3lopA:
undetectable
1ki7A-3lopA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
5 / 12 GLY A 355
GLU A 328
ARG A 331
ARG A 332
LEU A 349
None
0.96A 1mj2A-3lopA:
undetectable
1mj2B-3lopA:
undetectable
1mj2A-3lopA:
15.58
1mj2B-3lopA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
5 / 12 GLY A 355
GLU A 328
ARG A 331
ARG A 332
LEU A 349
None
0.90A 1mj2C-3lopA:
undetectable
1mj2D-3lopA:
undetectable
1mj2C-3lopA:
15.58
1mj2D-3lopA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
5 / 12 GLY A 355
GLU A 328
ARG A 331
ARG A 332
LEU A 349
None
0.95A 1mjoC-3lopA:
undetectable
1mjoD-3lopA:
undetectable
1mjoC-3lopA:
15.58
1mjoD-3lopA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
4 / 7 GLY A 112
GLN A 179
VAL A 111
PRO A  43
LEU  A 400 (-3.3A)
None
LEU  A 400 (-3.8A)
None
1.07A 1rxcL-3lopA:
undetectable
1rxcL-3lopA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
5 / 12 ALA A 329
LEU A 346
ALA A 345
ILE A  39
LEU A  79
None
None
None
None
EDO  A 401 ( 4.5A)
0.70A 2aclA-3lopA:
undetectable
2aclE-3lopA:
undetectable
2aclA-3lopA:
22.46
2aclE-3lopA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
4 / 6 ALA A 327
ILE A  36
VAL A  38
PHE A  63
None
0.96A 2cizA-3lopA:
undetectable
2cizA-3lopA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
4 / 5 ARG A 315
THR A  51
LEU A  42
ALA A 136
LEU  A 400 (-2.7A)
LEU  A 400 ( 4.1A)
None
LEU  A 400 ( 4.3A)
1.12A 2e1qD-3lopA:
undetectable
2e1qD-3lopA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
5 / 12 GLU A 318
LEU A 346
GLY A 134
GLN A  40
ILE A 151
None
1.26A 2e7fB-3lopA:
3.6
2e7fB-3lopA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
4 / 6 SER A  41
VAL A 110
ASP A  83
PRO A  43
None
1.24A 2hdnJ-3lopA:
3.0
2hdnK-3lopA:
undetectable
2hdnL-3lopA:
2.0
2hdnJ-3lopA:
23.28
2hdnK-3lopA:
10.32
2hdnL-3lopA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
5 / 12 GLU A 318
LEU A 346
GLY A 134
GLN A  40
ILE A 151
None
1.32A 2ogyB-3lopA:
4.1
2ogyB-3lopA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
5 / 12 GLY A  58
GLY A 319
GLU A 318
ASP A 311
VAL A 310
None
1.01A 2wa2A-3lopA:
3.1
2wa2A-3lopA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
4 / 8 ARG A 365
SER A 259
GLY A 134
PRO A 135
None
MG  A 408 ( 4.0A)
None
None
0.55A 3hcrA-3lopA:
5.4
3hcrA-3lopA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
3 / 3 ARG A 315
GLU A 158
TYR A 278
LEU  A 400 (-2.7A)
None
None
0.80A 3k37B-3lopA:
undetectable
3k37B-3lopA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
5 / 11 MET A 142
SER A 141
ILE A  88
ALA A 118
LEU A 119
None
1.45A 3pcqB-3lopA:
undetectable
3pcqB-3lopA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
4 / 7 ARG A 315
THR A  51
LEU A  42
ALA A 136
LEU  A 400 (-2.7A)
LEU  A 400 ( 4.1A)
None
LEU  A 400 ( 4.3A)
1.02A 3uniA-3lopA:
1.5
3uniA-3lopA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
4 / 7 GLY A 112
GLN A 179
VAL A 111
PRO A  43
LEU  A 400 (-3.3A)
None
LEU  A 400 (-3.8A)
None
1.07A 4e1vB-3lopA:
undetectable
4e1vB-3lopA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_B_PQNB840_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
5 / 9 MET A 142
SER A 141
ILE A  88
ALA A 118
LEU A 119
None
1.45A 4fe1B-3lopA:
undetectable
4fe1B-3lopA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
5 / 12 VAL A 191
LEU A 195
ILE A 159
LEU A 166
ALA A 165
None
1.04A 4p65F-3lopA:
undetectable
4p65H-3lopA:
undetectable
4p65K-3lopA:
undetectable
4p65L-3lopA:
undetectable
4p65F-3lopA:
6.82
4p65H-3lopA:
6.82
4p65K-3lopA:
9.72
4p65L-3lopA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
3 / 3 ALA A 118
GLN A  86
THR A  91
None
0.68A 5n0oA-3lopA:
3.6
5n0oA-3lopA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
5 / 12 GLY A  58
GLY A 319
GLU A 318
ASP A 311
VAL A 310
None
0.92A 5njvD-3lopA:
3.4
5njvD-3lopA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
4 / 6 ARG A 343
ALA A 106
PRO A 131
PHE A 149
None
1.36A 5odqA-3lopA:
5.2
5odqA-3lopA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
5 / 12 GLU A 192
GLU A 158
THR A 113
SER A 260
GLY A 138
None
None
LEU  A 400 (-3.7A)
LEU  A 400 (-4.6A)
None
1.11A 5xioA-3lopA:
3.0
5xioA-3lopA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_A_GM4A301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
5 / 11 VAL A 133
TYR A 352
LEU A 349
TYR A  62
ALA A 322
None
1.29A 6dk1A-3lopA:
undetectable
6dk1A-3lopA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
5 / 11 VAL A 133
TYR A 352
LEU A 349
TYR A  62
ALA A 322
None
1.25A 6dk1C-3lopA:
undetectable
6dk1C-3lopA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
4 / 5 LEU A 119
THR A 109
ARG A 339
PRO A 104
None
1.01A 6ew0B-3lopA:
undetectable
6ew0B-3lopA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
4 / 5 LEU A 119
THR A 109
ARG A 339
PRO A 104
None
1.01A 6ew0D-3lopA:
undetectable
6ew0D-3lopA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
4 / 6 LEU A 119
THR A 109
ARG A 339
PRO A 104
None
1.01A 6ew0G-3lopA:
undetectable
6ew0G-3lopA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
4 / 5 LEU A 119
THR A 109
ARG A 339
PRO A 104
None
1.01A 6ew0H-3lopA:
undetectable
6ew0H-3lopA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
4 / 5 LEU A 119
THR A 109
ARG A 339
PRO A 104
None
1.01A 6ew0I-3lopA:
undetectable
6ew0I-3lopA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_B_PQNB2002_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
5 / 9 MET A 142
SER A 141
ILE A  88
ALA A 118
LEU A 119
None
1.42A 6hqbB-3lopA:
0.0
6hqbB-3lopA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum)
5 / 12 ALA A 329
THR A 363
PHE A 149
VAL A  38
TYR A  62
None
1.45A 6hu9N-3lopA:
undetectable
6hu9N-3lopA:
21.55