SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lor'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		5 / 11 ILE A  60
LEU A 153
ILE A 124
LEU A 146
ILE A  56
 None
 0.84A 1dhiB-3lorA:
undetectable		 1dhiB-3lorA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		5 / 12 ILE A  60
LEU A 153
ILE A 124
LEU A 146
ILE A  56
 None
 0.90A 1ra2A-3lorA:
undetectable		 1ra2A-3lorA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		5 / 12 ILE A  60
LEU A 153
ILE A 124
LEU A 146
ILE A  56
 None
 0.90A 1ra8A-3lorA:
undetectable		 1ra8A-3lorA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		5 / 12 ILE A  60
LEU A 153
ILE A 124
LEU A 146
ILE A  56
 None
 0.80A 1rb2A-3lorA:
undetectable		 1rb2A-3lorA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		5 / 12 ILE A  60
LEU A 153
ILE A 124
LEU A 146
ILE A  56
 None
 0.90A 1rb3B-3lorA:
undetectable		 1rb3B-3lorA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		5 / 12 ILE A  60
LEU A 153
ILE A 124
LEU A 146
ILE A  56
 None
 0.84A 1rd7A-3lorA:
undetectable		 1rd7A-3lorA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		5 / 12 ILE A  60
LEU A 153
ILE A 124
LEU A 146
ILE A  56
 None
 0.84A 1rd7B-3lorA:
undetectable		 1rd7B-3lorA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		5 / 12 ILE A  60
LEU A 153
ILE A 124
LEU A 146
ILE A  56
 None
 0.91A 1rx2A-3lorA:
undetectable		 1rx2A-3lorA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		5 / 12 ILE A  60
LEU A 153
ILE A 124
LEU A 146
ILE A  56
 None
 0.86A 1rx7A-3lorA:
undetectable		 1rx7A-3lorA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		5 / 12 ILE A  60
LEU A 153
ILE A 124
LEU A 146
ILE A  56
 None
 0.77A 2d0kA-3lorA:
undetectable		 2d0kA-3lorA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		5 / 12 ILE A  60
LEU A 153
ILE A 124
LEU A 146
ILE A  56
 None
 0.83A 2d0kB-3lorA:
undetectable		 2d0kB-3lorA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		3 / 3 MET A 102
VAL A  35
GLU A  11
 None
 0.85A 2x9gA-3lorA:
2.0		 2x9gA-3lorA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		5 / 12 ILE A  60
LEU A 153
ILE A 124
LEU A 146
ILE A  56
 None
 0.81A 4ej1A-3lorA:
undetectable		 4ej1A-3lorA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		4 / 8 ASP A  13
ASP A 101
VAL A  37
LEU A  10
 None
 1.00A 4f8hA-3lorA:
undetectable
4f8hB-3lorA:
undetectable		 4f8hA-3lorA:
21.09
4f8hB-3lorA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		4 / 8 ASP A  13
ASP A 101
VAL A  37
LEU A  10
 None
 0.89A 4f8hB-3lorA:
undetectable
4f8hC-3lorA:
undetectable		 4f8hB-3lorA:
21.09
4f8hC-3lorA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		4 / 8 ASP A  13
ASP A 101
VAL A  37
LEU A  10
 None
 0.97A 4f8hC-3lorA:
undetectable
4f8hD-3lorA:
undetectable		 4f8hC-3lorA:
21.09
4f8hD-3lorA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		4 / 8 ASP A  13
ASP A 101
VAL A  37
LEU A  10
 None
 0.97A 4f8hD-3lorA:
undetectable
4f8hE-3lorA:
undetectable		 4f8hD-3lorA:
21.09
4f8hE-3lorA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		4 / 8 VAL A  37
LEU A  10
ASP A  13
ASP A 101
 None
 0.94A 4f8hA-3lorA:
undetectable
4f8hE-3lorA:
undetectable		 4f8hA-3lorA:
21.09
4f8hE-3lorA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		5 / 12 ILE A  60
LEU A 153
ILE A 124
LEU A 146
ILE A  56
 None
 0.73A 4i13A-3lorA:
undetectable		 4i13A-3lorA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		4 / 5 GLY A  69
LEU A 118
LEU A  10
LEU A 146
 None
 0.86A 4o8fA-3lorA:
undetectable		 4o8fA-3lorA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		5 / 12 ILE A  60
LEU A 153
ILE A 124
LEU A 146
ILE A  56
 None
 0.90A 4p3rA-3lorA:
undetectable		 4p3rA-3lorA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		5 / 12 ILE A  60
LEU A 153
ILE A 124
LEU A 146
ILE A  56
 None
 0.91A 4x5gB-3lorA:
undetectable		 4x5gB-3lorA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		5 / 12 ILE A  60
LEU A 153
ILE A 124
LEU A 146
ILE A  56
 None
 0.80A 4x5iA-3lorA:
undetectable		 4x5iA-3lorA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		4 / 7 LEU A  23
GLY A  69
ALA A  99
ILE A  89
 None
 0.74A 4yjiA-3lorA:
undetectable		 4yjiA-3lorA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3lor THIOL-DISULFIDE
ISOMERASE AND
THIOREDOXINS
(Corynebacterium
glutamicum) 		5 / 12 ILE A  60
LEU A 153
ILE A 124
LEU A 146
ILE A  56
 None
 0.95A 5ujxA-3lorA:
undetectable		 5ujxA-3lorA:
20.12