SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lot'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3lot UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 GLU A 261
HIS A  49
HIS A  51
 ZN  A 501 (-2.7A)
ZN  A 501 (-3.4A)
ZN  A 501 (-3.4A)
 0.71A 1oe2A-3lotA:
undetectable		 1oe2A-3lotA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 3lot UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 6 ILE A 201
HIS A  49
GLU A 261
HIS A  51
 UNL  A 503 ( 4.4A)
ZN  A 501 (-3.4A)
ZN  A 501 (-2.7A)
ZN  A 501 (-3.4A)
 0.98A 1y93A-3lotA:
undetectable		 1y93A-3lotA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 3lot UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 5 LEU A 305
LEU A 303
LEU A 198
MET A  47
 None
 1.12A 2oaxF-3lotA:
undetectable		 2oaxF-3lotA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 3lot UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 MET A  47
ILE A  74
VAL A  34
ILE A  33
ILE A  50
 None
 1.24A 2yzqA-3lotA:
undetectable		 2yzqA-3lotA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3lot UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 PHE A 200
LEU A 248
GLY A 253
GLY A 254
ASP A 223
 None
 1.20A 3i5uA-3lotA:
undetectable		 3i5uA-3lotA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 3lot UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 ALA A  45
GLU A  36
ILE A  13
ASP A 262
GLY A 259
 None
None
None
UNL  A 503 ( 3.5A)
None
 1.17A 3k2hA-3lotA:
undetectable		 3k2hA-3lotA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NJZ_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)		 3lot UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 HIS A  51
ARG A 257
HIS A  49
ASP A 262
ILE A  17
 ZN  A 501 (-3.4A)
UNL  A 502 ( 2.6A)
ZN  A 501 (-3.4A)
UNL  A 503 ( 3.5A)
None
 1.46A 3njzA-3lotA:
undetectable		 3njzA-3lotA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3lot UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 ALA A  45
GLU A  36
ILE A  13
ASP A 262
GLY A 259
 None
None
None
UNL  A 503 ( 3.5A)
None
 1.21A 3nrrB-3lotA:
undetectable		 3nrrB-3lotA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 3lot UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		7 / 12 GLU A 261
PHE A 149
PHE A 120
THR A  91
GLY A  87
GLY A  89
ALA A  16
 ZN  A 501 (-2.7A)
UNL  A 504 ( 4.6A)
UNL  A 504 ( 4.8A)
UNL  A 504 ( 4.7A)
UNL  A 502 ( 3.2A)
None
UNL  A 504 ( 3.6A)
 1.30A 3tegA-3lotA:
undetectable		 3tegA-3lotA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3lot UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 11 HIS A  18
PHE A 120
GLY A  88
GLY A  87
ASN A 114
 None
UNL  A 504 ( 4.8A)
UNL  A 504 ( 3.6A)
UNL  A 502 ( 3.2A)
UNL  A 502 ( 3.0A)
 1.40A 4fglA-3lotA:
undetectable
4fglB-3lotA:
undetectable		 4fglA-3lotA:
24.92
4fglB-3lotA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TXN_B_URFB302_1
(URIDINE
PHOSPHORYLASE)		 3lot UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 7 THR A  86
MET A 115
ALA A 100
ILE A 162
 None
 0.96A 4txnB-3lotA:
undetectable		 4txnB-3lotA:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_H_MZMH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3lot UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 10 ASN A 166
GLU A  97
VAL A 103
LEU A 159
ALA A 158
 None
 1.32A 4yhaH-3lotA:
undetectable		 4yhaH-3lotA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 3lot UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 7 GLU A  36
GLU A 277
ALA A 272
TYR A  25
 None
 0.89A 4zz8A-3lotA:
undetectable		 4zz8A-3lotA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3lot UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 100
LEU A 159
ILE A 208
GLY A 237
PHE A 149
 None
None
None
None
UNL  A 504 ( 4.6A)
 1.02A 5eshA-3lotA:
undetectable		 5eshA-3lotA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 3lot UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 12 LEU A 198
THR A 183
ILE A 180
GLY A 178
ILE A 177
 None
 1.27A 5ifuA-3lotA:
undetectable		 5ifuA-3lotA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_A_6T0A304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3lot UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		5 / 10 GLY A  88
GLY A  87
ASN A 114
ILE A  17
PHE A 120
 UNL  A 504 ( 3.6A)
UNL  A 502 ( 3.2A)
UNL  A 502 ( 3.0A)
None
UNL  A 504 ( 4.8A)
 1.46A 5lbtA-3lotA:
undetectable
5lbtB-3lotA:
undetectable		 5lbtA-3lotA:
24.24
5lbtB-3lotA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 3lot UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		4 / 5 ILE A 201
HIS A  49
GLU A 261
HIS A  51
 UNL  A 503 ( 4.4A)
ZN  A 501 (-3.4A)
ZN  A 501 (-2.7A)
ZN  A 501 (-3.4A)
 1.02A 5n5kA-3lotA:
undetectable		 5n5kA-3lotA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 3lot UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 GLY A 237
LEU A 245
HIS A 202
 None
 0.61A 5u63A-3lotA:
undetectable		 5u63A-3lotA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 3lot UNCHARACTERIZED
PROTEIN
(Archaeoglobus
fulgidus) 		3 / 3 GLY A 237
LEU A 245
HIS A 202
 None
 0.61A 5u63B-3lotA:
undetectable		 5u63B-3lotA:
21.49