SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lou'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3004_1
(SERUM ALBUMIN)		 3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Burkholderia
mallei) 		4 / 7 GLU A 236
LEU A 234
VAL A 182
LEU A 176
 None
None
UNL  A 292 ( 4.6A)
UNL  A 292 ( 4.7A)
 0.90A 1hk3A-3louA:
undetectable		 1hk3A-3louA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Burkholderia
mallei) 		5 / 12 ALA A  24
LEU A  29
ARG A  32
MET A  84
LEU A  12
 None
 1.45A 1ya3B-3louA:
undetectable		 1ya3B-3louA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Burkholderia
mallei) 		5 / 12 ALA A  24
LEU A  29
ARG A  32
MET A  84
LEU A  12
 None
 1.43A 2aa6B-3louA:
undetectable		 2aa6B-3louA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Burkholderia
mallei) 		4 / 5 LEU A 282
ILE A 240
ILE A 196
ALA A 195
 None
 0.62A 2i2zA-3louA:
undetectable		 2i2zA-3louA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Burkholderia
mallei) 		4 / 4 LEU A 282
ILE A 240
ILE A 196
ALA A 195
 None
 0.76A 2i30A-3louA:
undetectable		 2i30A-3louA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Burkholderia
mallei) 		5 / 11 MET A 122
ILE A 124
LEU A 268
ILE A 175
LEU A 108
 None
 1.26A 3a50C-3louA:
undetectable		 3a50C-3louA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Burkholderia
mallei) 		5 / 12 MET A 122
ILE A 124
LEU A 268
ILE A 175
LEU A 108
 None
 1.25A 3a50E-3louA:
undetectable		 3a50E-3louA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Burkholderia
mallei) 		3 / 3 VAL A 247
LYS A 221
HIS A 213
 None
 0.91A 3elzA-3louA:
undetectable		 3elzA-3louA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_B_J3ZB1_1
(ESTROGEN RECEPTOR)		 3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Burkholderia
mallei) 		5 / 11 LEU A 111
LEU A 120
LEU A 173
GLY A 126
LEU A 143
 None
 1.24A 3hm1B-3louA:
undetectable		 3hm1B-3louA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Burkholderia
mallei) 		5 / 12 ALA A  24
LEU A  29
ARG A  32
MET A  84
LEU A  12
 None
 1.45A 3vhuA-3louA:
undetectable		 3vhuA-3louA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Burkholderia
mallei) 		5 / 10 SER A 169
ALA A 171
ILE A 127
LEU A 143
ILE A 124
 None
 1.11A 4dt8B-3louA:
undetectable		 4dt8B-3louA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Burkholderia
mallei) 		4 / 5 VAL A 247
LEU A 256
ILE A 223
LEU A 222
 None
 0.76A 4mghA-3louA:
undetectable		 4mghA-3louA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Burkholderia
mallei) 		3 / 3 PRO A 185
VAL A 230
HIS A 228
 None
UNL  A 292 ( 4.3A)
None
 0.66A 4pevC-3louA:
6.1		 4pevC-3louA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Burkholderia
mallei) 		3 / 3 PHE A 275
ARG A 194
ALA A  87
 None
None
EDO  A 298 (-3.9A)
 0.89A 6ecfB-3louA:
3.8		 6ecfB-3louA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE
(Burkholderia
mallei) 		4 / 6 MET A 100
ALA A 187
LEU A 191
ALA A 195
 None
 0.88A 6fosB-3louA:
undetectable		 6fosB-3louA:
13.17