SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lov'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
4 / 7 VAL A 372
VAL A 383
ILE A 402
LEU A 387
None
1.00A 1iepB-3lovA:
undetectable
1iepB-3lovA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 11 GLY A  12
GLY A  15
ILE A 284
PRO A 287
LEU A 304
FAD  A 500 (-3.4A)
None
FAD  A 500 (-3.7A)
None
None
0.92A 1p91A-3lovA:
undetectable
1p91A-3lovA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 12 ALA A  17
LEU A  68
LEU A  71
ILE A  72
LEU A 234
None
0.91A 1xdkB-3lovA:
undetectable
1xdkB-3lovA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 12 ALA A  17
LEU A  68
LEU A  71
ILE A  72
LEU A 234
None
0.91A 1xdkF-3lovA:
undetectable
1xdkF-3lovA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
4 / 6 LEU A 405
LYS A  43
PRO A 410
VAL A 444
FAD  A 500 ( 4.0A)
FAD  A 500 (-2.8A)
None
FAD  A 500 (-4.9A)
1.08A 2dqyC-3lovA:
undetectable
2dqyC-3lovA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3V_A_TOPA1169_1
(DIHYDROFOLATE
REDUCTASE)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 12 VAL A  44
LEU A 230
LEU A  71
ILE A  13
THR A  46
None
None
None
FAD  A 500 (-4.8A)
None
1.11A 2w3vA-3lovA:
undetectable
2w3vA-3lovA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_A_Y00A601_1
(BETA-1 ADRENERGIC
RECEPTOR)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 12 LEU A 428
VAL A 427
SER A   2
SER A   3
TYR A 266
None
1.24A 2y00A-3lovA:
undetectable
2y00A-3lovA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 12 LEU A 428
VAL A 427
SER A   2
SER A   3
TYR A 266
None
1.21A 2y00B-3lovA:
undetectable
2y00B-3lovA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y01_B_Y00B601_1
(BETA-1 ADRENERGIC
RECEPTOR)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 12 LEU A 428
VAL A 427
SER A   2
SER A   3
TYR A 266
None
1.21A 2y01B-3lovA:
undetectable
2y01B-3lovA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1001_1
(LYSR-TYPE REGULATORY
PROTEIN)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
4 / 6 SER A 403
ARG A 360
PRO A  58
GLY A  57
None
None
FAD  A 500 (-3.7A)
None
1.46A 2y7pA-3lovA:
undetectable
2y7pA-3lovA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 12 ILE A 284
LEU A 256
ILE A 259
VAL A 427
VAL A 423
FAD  A 500 (-3.7A)
FAD  A 500 (-4.9A)
None
None
None
1.12A 2ygnA-3lovA:
undetectable
2ygnA-3lovA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 12 GLY A  15
GLY A  10
ILE A 250
LEU A 281
ALA A 453
None
FAD  A 500 (-3.3A)
None
None
None
0.99A 2yqzA-3lovA:
undetectable
2yqzA-3lovA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 9 LEU A 387
VAL A 358
ILE A  54
ILE A 402
PRO A 397
None
1.11A 3ekqB-3lovA:
undetectable
3ekqB-3lovA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 9 LEU A   6
ALA A  17
THR A  14
ALA A 437
THR A 283
None
None
FAD  A 500 (-3.5A)
None
None
1.20A 3mdtA-3lovA:
undetectable
3mdtA-3lovA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 11 LEU A 169
ILE A 100
ALA A 341
THR A 343
ALA A  89
None
1.08A 3mdtB-3lovA:
undetectable
3mdtB-3lovA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 11 LEU A 387
VAL A 358
ILE A  54
ILE A 402
PRO A 397
None
0.97A 4qgiB-3lovA:
undetectable
4qgiB-3lovA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 12 GLY A 415
TYR A 412
ALA A 185
ASP A 418
ALA A 417
None
1.36A 4ymgB-3lovA:
undetectable
4ymgB-3lovA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
4 / 6 ALA A 341
THR A 340
VAL A 331
VAL A 383
None
0.97A 5eckA-3lovA:
undetectable
5eckA-3lovA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
4 / 6 ALA A 341
THR A 340
VAL A 331
VAL A 383
None
0.99A 5eckD-3lovA:
undetectable
5eckD-3lovA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
4 / 6 ALA A 341
THR A 340
VAL A 331
VAL A 383
None
0.91A 5eclD-3lovA:
undetectable
5eclD-3lovA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 12 ALA A  17
GLY A  10
ALA A  18
THR A 283
ILE A   8
None
FAD  A 500 (-3.3A)
None
None
None
1.08A 5eeuI-3lovA:
undetectable
5eeuJ-3lovA:
undetectable
5eeuI-3lovA:
10.78
5eeuJ-3lovA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 12 ALA A  17
GLY A  10
ALA A  18
THR A 283
ILE A   8
None
FAD  A 500 (-3.3A)
None
None
None
1.08A 5eevI-3lovA:
undetectable
5eevJ-3lovA:
undetectable
5eevI-3lovA:
10.78
5eevJ-3lovA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 12 ALA A  17
GLY A  10
ALA A  18
THR A 283
ILE A   8
None
FAD  A 500 (-3.3A)
None
None
None
1.08A 5eewI-3lovA:
undetectable
5eewJ-3lovA:
undetectable
5eewI-3lovA:
10.78
5eewJ-3lovA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 12 GLU A 463
GLY A 438
THR A  14
LEU A 281
MET A 456
None
FAD  A 500 (-3.6A)
FAD  A 500 (-3.5A)
None
None
1.31A 5esgA-3lovA:
undetectable
5esgA-3lovA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 12 ASP A 369
HIS A 307
ALA A 175
SER A 171
THR A 311
None
1.23A 5hnzB-3lovA:
undetectable
5hnzB-3lovA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 12 PRO A 397
VAL A 312
ALA A 341
VAL A 383
GLY A 328
None
1.02A 5igtA-3lovA:
undetectable
5igtA-3lovA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 9 LEU A 387
VAL A 358
ILE A  54
ILE A 402
PRO A 397
None
1.11A 5kqxB-3lovA:
undetectable
5kqxB-3lovA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 12 LEU A 281
ALA A 437
LEU A  71
ILE A 457
LEU A 241
None
1.12A 5ljeA-3lovA:
undetectable
5ljeA-3lovA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
6 / 12 LEU A  71
THR A  69
ILE A  67
LEU A 237
LEU A 234
LEU A 446
None
None
None
None
None
FAD  A 500 (-3.7A)
1.39A 5nfjA-3lovA:
2.9
5nfjA-3lovA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 12 LEU A 304
VAL A 444
GLY A 443
ASP A 442
GLY A 438
None
FAD  A 500 (-4.9A)
None
None
FAD  A 500 (-3.6A)
0.90A 5nnaA-3lovA:
undetectable
5nnaA-3lovA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 12 LEU A 304
VAL A 444
GLY A 443
ASP A 442
GLY A 438
None
FAD  A 500 (-4.9A)
None
None
FAD  A 500 (-3.6A)
0.94A 5nnaB-3lovA:
undetectable
5nnaB-3lovA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 12 LEU A 304
VAL A 444
GLY A 443
ASP A 442
GLY A 438
None
FAD  A 500 (-4.9A)
None
None
FAD  A 500 (-3.6A)
0.93A 5nnaC-3lovA:
undetectable
5nnaC-3lovA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 12 LEU A 304
VAL A 444
GLY A 443
ASP A 442
GLY A 438
None
FAD  A 500 (-4.9A)
None
None
FAD  A 500 (-3.6A)
0.90A 5nnaD-3lovA:
undetectable
5nnaD-3lovA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
4 / 6 ARG A  56
THR A 311
ARG A 404
LEU A 405
None
None
None
FAD  A 500 ( 4.0A)
1.16A 5tdzA-3lovA:
3.2
5tdzA-3lovA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
3 / 3 GLU A 151
TYR A 152
ARG A 156
None
0.65A 5uunA-3lovA:
undetectable
5uunA-3lovA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
3 / 3 GLU A 151
TYR A 152
ARG A 156
None
0.62A 5uunB-3lovA:
undetectable
5uunB-3lovA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
5 / 12 ALA A  36
GLU A 275
LEU A  33
ILE A   8
TYR A 441
FAD  A 500 (-3.6A)
None
None
None
None
1.49A 5vlmA-3lovA:
undetectable
5vlmA-3lovA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
4 / 8 THR A  14
GLY A  15
ALA A  18
GLY A  10
FAD  A 500 (-3.5A)
None
None
FAD  A 500 (-3.3A)
0.71A 5vw9A-3lovA:
3.4
5vw9A-3lovA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)
3lov PROTOPORPHYRINOGEN
OXIDASE

(Exiguobacterium
sibiricum)
4 / 6 PRO A 155
ILE A 147
GLY A 150
TYR A 152
None
0.94A 6gqiA-3lovA:
4.8
6gqiA-3lovA:
24.51