SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lp8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_1
(NEURAMINIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.23A 1a4gB-3lp8A:
undetectable		 1a4gB-3lp8A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		3 / 3 LEU A 297
SER A 295
ASN A 383
 None
 0.71A 1bx4A-3lp8A:
undetectable		 1bx4A-3lp8A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NNC_A_ZMRA479_1
(NEURAMINIDASE N9)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.28A 1nncA-3lp8A:
undetectable		 1nncA-3lp8A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		4 / 7 LEU A 207
PHE A 288
LEU A 300
PHE A  90
 None
 0.95A 1wrlE-3lp8A:
undetectable
1wrlF-3lp8A:
undetectable		 1wrlE-3lp8A:
11.70
1wrlF-3lp8A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		3 / 3 GLY A 350
GLU A 352
ASP A 406
 None
 0.56A 2b25B-3lp8A:
2.8		 2b25B-3lp8A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		4 / 5 LEU A 357
ASN A 359
VAL A 384
ALA A 401
 None
 0.84A 2cizA-3lp8A:
undetectable		 2cizA-3lp8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1477_1
(NEURAMINIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.28A 2cmlA-3lp8A:
undetectable		 2cmlA-3lp8A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2477_1
(NEURAMINIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.28A 2cmlB-3lp8A:
undetectable		 2cmlB-3lp8A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3477_1
(NEURAMINIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.26A 2cmlC-3lp8A:
undetectable		 2cmlC-3lp8A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4477_1
(NEURAMINIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.32A 2cmlD-3lp8A:
undetectable		 2cmlD-3lp8A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 11 ILE A  30
GLY A 366
THR A 367
HIS A 364
GLY A  33
 None
 1.29A 2fn1A-3lp8A:
undetectable		 2fn1A-3lp8A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 11 ILE A  30
GLY A 366
THR A 367
HIS A 364
GLY A  33
 None
 1.32A 2fn1B-3lp8A:
undetectable		 2fn1B-3lp8A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		4 / 6 LEU A 357
ASN A 359
VAL A 384
ALA A 401
 None
 0.85A 2j5mA-3lp8A:
undetectable		 2j5mA-3lp8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		3 / 3 ASN A 383
LEU A 362
HIS A 364
 None
 0.72A 2q6fB-3lp8A:
0.5		 2q6fB-3lp8A:
20.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 8 ASN A 285
ARG A 287
GLY A 289
PRO A 291
GLU A 292
 None
 0.33A 2ys6A-3lp8A:
51.9		 2ys6A-3lp8A:
42.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		4 / 6 GLY A 350
ILE A 354
GLU A 352
ASP A 406
 None
 0.76A 3a7eA-3lp8A:
4.3		 3a7eA-3lp8A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_A_ZMRA1001_1
(NEURAMINIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.32A 3b7eA-3lp8A:
undetectable		 3b7eA-3lp8A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B7E_B_ZMRB1002_1
(NEURAMINIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.32A 3b7eB-3lp8A:
undetectable		 3b7eB-3lp8A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_1
(NEURAMINIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.37A 3ckzA-3lp8A:
undetectable		 3ckzA-3lp8A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 GLU A  71
PHE A 269
ARG A  11
GLU A 292
GLY A 227
 None
 1.08A 3jzjA-3lp8A:
undetectable		 3jzjA-3lp8A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 GLY A 379
GLY A   9
SER A  14
ALA A 365
ASN A 383
 UNX  A 423 ( 3.9A)
None
None
None
None
 1.08A 3kkzB-3lp8A:
3.0		 3kkzB-3lp8A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_A_ZMRA901_1
(NEURAMINIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.29A 3sanA-3lp8A:
undetectable		 3sanA-3lp8A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SAN_B_ZMRB901_1
(NEURAMINIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.28A 3sanB-3lp8A:
undetectable		 3sanB-3lp8A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_A_ZMRA1002_1
(NEURAMINIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.28A 3ti5A-3lp8A:
undetectable		 3ti5A-3lp8A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI5_B_ZMRB1002_1
(NEURAMINIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.29A 3ti5B-3lp8A:
undetectable		 3ti5B-3lp8A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_A_ZMRA1002_1
(NEURAMINIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.27A 3ticA-3lp8A:
undetectable		 3ticA-3lp8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_B_ZMRB1002_1
(NEURAMINIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.27A 3ticB-3lp8A:
undetectable		 3ticB-3lp8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_C_ZMRC1002_1
(NEURAMINIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.27A 3ticC-3lp8A:
undetectable		 3ticC-3lp8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TIC_D_ZMRD1002_1
(NEURAMINIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.26A 3ticD-3lp8A:
undetectable		 3ticD-3lp8A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 THR A 311
PHE A  90
LEU A 300
VAL A 321
PHE A 288
 None
 1.08A 3u9fD-3lp8A:
undetectable
3u9fE-3lp8A:
undetectable		 3u9fD-3lp8A:
17.42
3u9fE-3lp8A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 THR A 311
PHE A  90
LEU A 300
VAL A 321
PHE A 288
 None
 1.10A 3u9fG-3lp8A:
undetectable
3u9fH-3lp8A:
undetectable		 3u9fG-3lp8A:
17.42
3u9fH-3lp8A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 11 THR A 311
PHE A  90
LEU A 300
VAL A 321
PHE A 288
 None
 1.04A 3u9fN-3lp8A:
undetectable
3u9fO-3lp8A:
undetectable		 3u9fN-3lp8A:
17.42
3u9fO-3lp8A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 PHE A 288
THR A 311
PHE A  90
LEU A 300
VAL A 321
 None
 1.14A 3u9fP-3lp8A:
undetectable
3u9fS-3lp8A:
undetectable		 3u9fP-3lp8A:
17.42
3u9fS-3lp8A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_1
(NEURAMINIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.32A 4b7nA-3lp8A:
undetectable		 4b7nA-3lp8A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_1
(NEURAMINIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.26A 4b7qA-3lp8A:
undetectable		 4b7qA-3lp8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_B_ZMRB601_1
(NEURAMINIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.33A 4b7qB-3lp8A:
undetectable		 4b7qB-3lp8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_D_ZMRD601_1
(NEURAMINIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.32A 4b7qD-3lp8A:
undetectable		 4b7qD-3lp8A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_1
(NEURAMINIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.28A 4cpzC-3lp8A:
undetectable		 4cpzC-3lp8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_D_ZMRD1471_1
(NEURAMINIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.23A 4cpzD-3lp8A:
undetectable		 4cpzD-3lp8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 11 LYS A 214
ILE A 274
LEU A 282
GLY A 271
ALA A 118
 None
 1.29A 4fogD-3lp8A:
undetectable		 4fogD-3lp8A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_1
(NEURAMINIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.30A 4mwrA-3lp8A:
undetectable		 4mwrA-3lp8A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		3 / 3 ASP A 145
LYS A 107
LEU A 281
 None
 1.07A 4ptjA-3lp8A:
undetectable		 4ptjA-3lp8A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 TYR A 414
ILE A 216
GLY A 217
ASN A 219
ILE A 411
 None
 1.06A 4rvgA-3lp8A:
3.1		 4rvgA-3lp8A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WA5_A_ZMRA501_1
(NEURAMINIDASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 ARG A 380
GLU A 100
GLU A  71
ARG A 287
ASN A 285
 UNX  A 425 ( 4.0A)
None
None
None
None
 1.32A 4wa5A-3lp8A:
undetectable		 4wa5A-3lp8A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		3 / 3 SER A  79
GLU A 100
GLU A 292
 None
 0.59A 4ymgB-3lp8A:
undetectable		 4ymgB-3lp8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_G_CHDG103_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 11 MET A 228
GLY A 227
GLN A 294
GLU A 292
THR A 293
 None
 1.36A 5b1bG-3lp8A:
undetectable
5b1bN-3lp8A:
undetectable
5b1bO-3lp8A:
undetectable		 5b1bG-3lp8A:
15.69
5b1bN-3lp8A:
21.88
5b1bO-3lp8A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_2
(WTFP-TAG,GP41)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		3 / 3 LEU A 404
LEU A 405
TRP A 407
 None
 0.86A 5nwuA-3lp8A:
undetectable		 5nwuA-3lp8A:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		4 / 8 THR A 225
TYR A 342
GLN A 149
GLY A 366
 None
None
UNX  A 426 ( 4.3A)
None
 1.01A 5nzyA-3lp8A:
undetectable		 5nzyA-3lp8A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		3 / 3 GLY A  10
LEU A 363
HIS A  13
 None
 0.70A 5u63A-3lp8A:
3.2		 5u63A-3lp8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 LYS A 214
ILE A 274
LEU A 282
GLY A 271
ALA A 118
 None
 1.15A 5x66F-3lp8A:
undetectable		 5x66F-3lp8A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		5 / 12 PHE A 175
GLY A 152
VAL A 141
GLY A 176
ALA A 181
 None
 1.08A 6c2mA-3lp8A:
undetectable		 6c2mA-3lp8A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		4 / 4 LYS A 313
LEU A 310
ALA A 312
LEU A 316
 None
 1.48A 6gnrA-3lp8A:
undetectable		 6gnrA-3lp8A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE
(Ehrlichia
chaffeensis) 		4 / 4 LYS A 313
LEU A 310
ALA A 312
LEU A 316
 None
 1.48A 6gnrB-3lp8A:
undetectable		 6gnrB-3lp8A:
12.81