SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lpd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		3 / 3 ASP A  79
ARG A 136
ILE A  61
 None
 0.76A 1a4gB-3lpdA:
undetectable		 1a4gB-3lpdA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		5 / 9 THR A 229
LEU A 325
VAL A 245
GLY A 326
VAL A 283
 None
 1.38A 1dz8A-3lpdA:
undetectable		 1dz8A-3lpdA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		5 / 9 THR A 229
LEU A 325
VAL A 245
GLY A 326
VAL A 283
 None
 1.38A 1dz8B-3lpdA:
undetectable		 1dz8B-3lpdA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		5 / 9 THR A 229
LEU A 325
VAL A 245
GLY A 326
VAL A 283
 None
 1.41A 1dz9B-3lpdA:
undetectable		 1dz9B-3lpdA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		3 / 3 ASP A  79
ASP A  69
ASP A  41
 None
CA  A 342 ( 2.5A)
None
 0.79A 1eizA-3lpdA:
undetectable		 1eizA-3lpdA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		3 / 3 ASP A  79
ASP A  69
ASP A  41
 None
CA  A 342 ( 2.5A)
None
 0.79A 1ej0A-3lpdA:
undetectable		 1ej0A-3lpdA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		3 / 3 ALA A 115
VAL A 126
TRP A  26
 None
 0.89A 1jo3A-3lpdA:
undetectable		 1jo3A-3lpdA:
3.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		3 / 3 ALA A 115
VAL A 126
TRP A  26
 None
 0.89A 1jo3B-3lpdA:
undetectable		 1jo3B-3lpdA:
3.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 8 ASN A  53
GLY A 111
THR A 257
GLY A 122
 None
None
None
CA  A   1 ( 4.3A)
 0.70A 1jr1B-3lpdA:
undetectable		 1jr1B-3lpdA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 6 TRP A  26
HIS A 282
TYR A  14
GLY A  19
 None
 1.39A 1mxdA-3lpdA:
2.2		 1mxdA-3lpdA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		3 / 3 ALA A 115
VAL A 126
TRP A  26
 None
 0.83A 1nt6A-3lpdA:
undetectable		 1nt6A-3lpdA:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		3 / 3 ALA A 115
VAL A 126
TRP A  26
 None
 0.82A 1nt6B-3lpdA:
undetectable		 1nt6B-3lpdA:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		5 / 12 ALA A 287
ILE A 291
VAL A  37
ALA A  38
LEU A  55
 None
 1.19A 1udtA-3lpdA:
undetectable		 1udtA-3lpdA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XP0_A_VDNA201_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		5 / 10 ALA A 287
ILE A 291
VAL A  37
ALA A  38
LEU A  55
 None
 1.20A 1xp0A-3lpdA:
undetectable		 1xp0A-3lpdA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		5 / 9 THR A 229
LEU A 325
VAL A 245
GLY A 326
VAL A 283
 None
 1.37A 2a1oB-3lpdA:
undetectable		 2a1oB-3lpdA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		3 / 3 ASP A  79
VAL A  39
PRO A 281
 None
 0.76A 2avvA-3lpdA:
undetectable		 2avvA-3lpdA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 5 VAL A 297
SER A 292
VAL A 290
SER A 296
 None
 1.30A 2j9cA-3lpdA:
undetectable
2j9cB-3lpdA:
undetectable
2j9cC-3lpdA:
undetectable		 2j9cA-3lpdA:
16.81
2j9cB-3lpdA:
16.81
2j9cC-3lpdA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 5 ILE A 254
HIS A 108
TYR A  14
GLY A 111
 None
 1.26A 3b9mA-3lpdA:
undetectable		 3b9mA-3lpdA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		5 / 12 ILE A 191
ILE A 160
LEU A 197
VAL A 201
ARG A 196
 None
 1.20A 3fpjB-3lpdA:
2.1		 3fpjB-3lpdA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		5 / 12 GLY A 122
GLY A 125
GLN A  11
ALA A 115
ASN A  53
 CA  A   1 ( 4.3A)
None
None
None
None
 0.96A 3kkzB-3lpdA:
undetectable		 3kkzB-3lpdA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		5 / 10 TYR A  14
VAL A 126
GLY A 125
VAL A 330
GLY A 285
 None
 1.03A 3km6A-3lpdA:
undetectable		 3km6A-3lpdA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		5 / 9 TYR A  14
VAL A 126
GLY A 125
VAL A 330
GLY A 285
 None
 1.04A 3kmoA-3lpdA:
undetectable		 3kmoA-3lpdA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 7 TYR A  14
VAL A 126
VAL A 330
GLY A 285
 None
 1.04A 3kmoB-3lpdA:
undetectable		 3kmoB-3lpdA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 8 GLY A 227
ILE A 254
MET A 273
PHE A 238
 None
 0.76A 3ko0B-3lpdA:
undetectable
3ko0J-3lpdA:
undetectable		 3ko0B-3lpdA:
12.68
3ko0J-3lpdA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 8 GLY A 227
ILE A 254
MET A 273
PHE A 238
 None
 0.81A 3ko0K-3lpdA:
undetectable
3ko0S-3lpdA:
undetectable		 3ko0K-3lpdA:
12.68
3ko0S-3lpdA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 7 LEU A 321
THR A 229
ILE A 329
GLY A 326
 None
 0.80A 4eq4A-3lpdA:
undetectable		 4eq4A-3lpdA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 8 LEU A 321
THR A 229
ILE A 329
GLY A 326
 None
 0.85A 4eq4B-3lpdA:
undetectable		 4eq4B-3lpdA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 7 LEU A 321
THR A 229
ILE A 329
GLY A 326
 None
 0.83A 4eqlA-3lpdA:
undetectable		 4eqlA-3lpdA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 7 LEU A 321
THR A 229
ILE A 329
GLY A 326
 None
 0.81A 4eqlB-3lpdA:
undetectable		 4eqlB-3lpdA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 8 ASN A  53
GLY A 111
THR A 257
GLY A 122
 None
None
None
CA  A   1 ( 4.3A)
 0.64A 4fo4B-3lpdA:
undetectable		 4fo4B-3lpdA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		5 / 9 VAL A 132
VAL A 133
VAL A 109
ILE A 113
ALA A 130
 None
 1.23A 4fwdA-3lpdA:
undetectable		 4fwdA-3lpdA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 7 LEU A 321
THR A 229
ILE A 329
GLY A 326
 None
 0.89A 4l39B-3lpdA:
undetectable		 4l39B-3lpdA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		5 / 12 ALA A 124
GLY A 125
ASN A  53
GLY A 122
ASN A 118
 None
None
None
CA  A   1 ( 4.3A)
None
 1.14A 4obwA-3lpdA:
2.5		 4obwA-3lpdA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 5 ILE A 113
VAL A  37
PHE A  60
HIS A 282
 None
 1.14A 4rzvA-3lpdA:
undetectable		 4rzvA-3lpdA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 6 ASP A  49
ALA A 124
THR A 257
TYR A 270
 CA  A   1 (-2.2A)
None
None
None
 1.38A 4w5qA-3lpdA:
undetectable		 4w5qA-3lpdA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 6 ASP A  49
ALA A 124
THR A 257
TYR A 270
 CA  A   1 (-2.2A)
None
None
None
 1.37A 4w5rA-3lpdA:
undetectable		 4w5rA-3lpdA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 6 ASP A  49
ALA A 124
THR A 257
TYR A 270
 CA  A   1 (-2.2A)
None
None
None
 1.40A 4w5tA-3lpdA:
undetectable		 4w5tA-3lpdA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		5 / 11 ASP A 331
ALA A 288
VAL A 290
VAL A 126
GLY A 285
 None
 1.27A 4xnxA-3lpdA:
undetectable		 4xnxA-3lpdA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 5 ASP A  82
VAL A 258
ASP A 259
GLY A 261
 None
 1.24A 4xp6A-3lpdA:
undetectable		 4xp6A-3lpdA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 6 ASP A  49
ALA A 124
THR A 257
TYR A 270
 CA  A   1 (-2.2A)
None
None
None
 1.39A 4z4cA-3lpdA:
undetectable		 4z4cA-3lpdA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 6 ASP A  49
ALA A 124
THR A 257
TYR A 270
 CA  A   1 (-2.2A)
None
None
None
 1.37A 4z4fA-3lpdA:
2.0		 4z4fA-3lpdA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 5 ASP A  49
ALA A 124
THR A 257
TYR A 270
 CA  A   1 (-2.2A)
None
None
None
 1.38A 4z4gA-3lpdA:
undetectable		 4z4gA-3lpdA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 6 ASP A  49
ALA A 124
THR A 257
TYR A 270
 CA  A   1 (-2.2A)
None
None
None
 1.42A 4z4iA-3lpdA:
2.2		 4z4iA-3lpdA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 6 ALA A 279
THR A 280
VAL A 283
VAL A 245
 None
 0.97A 5eclA-3lpdA:
undetectable		 5eclA-3lpdA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 6 ALA A 279
THR A 280
VAL A 283
VAL A 245
 None
 0.83A 5eclD-3lpdA:
undetectable		 5eclD-3lpdA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 4 ALA A  75
PRO A 134
LEU A  45
HIS A  46
 None
 1.33A 5eskA-3lpdA:
0.1		 5eskA-3lpdA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 5 PRO A   3
HIS A 282
LEU A  50
PHE A 272
 None
 1.42A 5igjA-3lpdA:
undetectable		 5igjA-3lpdA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		3 / 3 ASP A 331
ASN A 337
PHE A  15
 None
 0.63A 5jglB-3lpdA:
undetectable		 5jglB-3lpdA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		5 / 12 VAL A  37
ALA A 204
VAL A 109
GLY A 111
ALA A 110
 None
 1.10A 5kirB-3lpdA:
undetectable		 5kirB-3lpdA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 7 LEU A 247
ALA A 249
THR A 229
LEU A 325
 None
 1.00A 5te8A-3lpdA:
undetectable		 5te8A-3lpdA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3lpd ACIDIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE APRV2
(Dichelobacter
nodosus) 		4 / 7 VAL A 330
HIS A 282
PRO A 250
ILE A 254
 None
 1.06A 5vkqA-3lpdA:
undetectable
5vkqD-3lpdA:
undetectable		 5vkqA-3lpdA:
12.27
5vkqD-3lpdA:
12.27