SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lpe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3lpe PUTATIVE
TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG
(Methanocaldococc
us
jannaschii) 		5 / 10 GLN A  11
MET A  60
ILE A  57
VAL A   5
VAL A  43
 None
 1.23A 3fhjA-3lpeA:
undetectable		 3fhjA-3lpeA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3lpe PUTATIVE
TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG
(Methanocaldococc
us
jannaschii) 		5 / 10 GLN A  11
MET A  60
ILE A  57
VAL A   5
VAL A  43
 None
 1.27A 3fhjB-3lpeA:
undetectable		 3fhjB-3lpeA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3lpe PUTATIVE
TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG
(Methanocaldococc
us
jannaschii) 		5 / 10 GLN A  11
MET A  60
ILE A  57
VAL A   5
VAL A  43
 None
 1.21A 3fhjC-3lpeA:
undetectable		 3fhjC-3lpeA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3lpe PUTATIVE
TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG
(Methanocaldococc
us
jannaschii) 		5 / 10 GLN A  11
MET A  60
ILE A  57
VAL A   5
VAL A  43
 None
 1.18A 3fhjE-3lpeA:
undetectable		 3fhjE-3lpeA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 3lpe PUTATIVE
TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG
(Methanocaldococc
us
jannaschii) 		5 / 10 VAL A  63
ALA A   4
VAL A  45
ILE A  66
ILE A  15
 None
 1.21A 3retA-3lpeA:
undetectable
3retB-3lpeA:
undetectable		 3retA-3lpeA:
22.43
3retB-3lpeA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 3lpe DNA-DIRECTED RNA
POLYMERASE SUBUNIT
E''
(Methanocaldococc
us
jannaschii) 		5 / 9 ALA B  42
ASP B  48
ILE B  49
GLY B  51
ILE B  32
 None
 1.26A 3u7sB-3lpeB:
undetectable		 3u7sB-3lpeB:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 3lpe PUTATIVE
TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG
(Methanocaldococc
us
jannaschii) 		5 / 9 ALA A  47
ILE A  33
ILE A  76
ILE A  66
VAL A  53
 None
 1.02A 4nptA-3lpeA:
undetectable		 4nptA-3lpeA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3lpe PUTATIVE
TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
E''
(Methanocaldococc
us
jannaschii;
Methanocaldococc
us
jannaschii) 		5 / 12 ILE B  32
GLY A  17
LYS B  50
GLU A  24
VAL A  30
 None
 1.24A 5hw4A-3lpeB:
undetectable		 5hw4A-3lpeB:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_B_SAMB801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 3lpe PUTATIVE
TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
E''
(Methanocaldococc
us
jannaschii;
Methanocaldococc
us
jannaschii) 		5 / 11 ILE B  32
GLY A  17
LYS B  50
GLU A  24
VAL A  30
 None
 1.33A 5hw4B-3lpeB:
undetectable		 5hw4B-3lpeB:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 3lpe DNA-DIRECTED RNA
POLYMERASE SUBUNIT
E''
(Methanocaldococc
us
jannaschii) 		5 / 9 ALA B  42
ASP B  48
ILE B  49
GLY B  51
ILE B  32
 None
 1.27A 5kr2C-3lpeB:
undetectable		 5kr2C-3lpeB:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 3lpe PUTATIVE
TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A  15
VAL A  45
ILE A  66
LEU A  56
 None
 0.75A 5og9A-3lpeA:
undetectable		 5og9A-3lpeA:
13.72