SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lpm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3lpm PUTATIVE
METHYLTRANSFERASE
(Listeria
monocytogenes) 		3 / 3 ARG A 180
ASN A 173
THR A 158
 None
 0.83A 2q63A-3lpmA:
undetectable		 2q63A-3lpmA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)		 3lpm PUTATIVE
METHYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 12 LEU A   8
LEU A   6
ILE A  25
ALA A  93
ASP A  86
 None
 1.02A 2qb4A-3lpmA:
undetectable		 2qb4A-3lpmA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 3lpm PUTATIVE
METHYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 9 LEU A  66
ILE A  62
GLY A  61
SER A  44
LEU A  40
 None
 1.18A 2qmmA-3lpmA:
undetectable		 2qmmA-3lpmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 3lpm PUTATIVE
METHYLTRANSFERASE
(Listeria
monocytogenes) 		3 / 3 LEU A   8
ARG A  13
ILE A   9
 None
 0.55A 2xn5B-3lpmA:
undetectable		 2xn5B-3lpmA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3lpm PUTATIVE
METHYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 9 ASP A  36
ILE A  35
VAL A 232
VAL A 230
GLN A 199
 None
 1.41A 3fhjD-3lpmA:
undetectable		 3fhjD-3lpmA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3lpm PUTATIVE
METHYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 9 ASP A  36
ILE A  35
VAL A 232
VAL A 230
GLN A 199
 None
 1.41A 3fhjF-3lpmA:
2.0		 3fhjF-3lpmA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3lpm PUTATIVE
METHYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 9 ASP A  36
ILE A  35
VAL A 232
VAL A 230
GLN A 199
 None
 1.38A 3fi0A-3lpmA:
undetectable		 3fi0A-3lpmA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3lpm PUTATIVE
METHYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 9 ASP A  36
ILE A  35
VAL A 232
VAL A 230
GLN A 199
 None
 1.40A 3fi0C-3lpmA:
undetectable		 3fi0C-3lpmA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3lpm PUTATIVE
METHYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 9 ASP A  36
ILE A  35
VAL A 232
VAL A 230
GLN A 199
 None
 1.41A 3fi0D-3lpmA:
undetectable		 3fi0D-3lpmA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3lpm PUTATIVE
METHYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 9 ASP A  36
ILE A  35
VAL A 232
VAL A 230
GLN A 199
 None
 1.39A 3fi0F-3lpmA:
undetectable		 3fi0F-3lpmA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3lpm PUTATIVE
METHYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 9 ASP A  36
ILE A  35
VAL A 232
VAL A 230
GLN A 199
 None
 1.41A 3fi0J-3lpmA:
undetectable		 3fi0J-3lpmA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3lpm PUTATIVE
METHYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 9 ASP A  36
ILE A  35
VAL A 232
VAL A 230
GLN A 199
 None
 1.44A 3fi0N-3lpmA:
undetectable		 3fi0N-3lpmA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3lpm PUTATIVE
METHYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 9 ASP A  36
ILE A  35
VAL A 232
VAL A 230
GLN A 199
 None
 1.44A 3fi0O-3lpmA:
undetectable		 3fi0O-3lpmA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3lpm PUTATIVE
METHYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 9 ASP A  36
ILE A  35
VAL A 232
VAL A 230
GLN A 199
 None
 1.43A 3fi0R-3lpmA:
undetectable		 3fi0R-3lpmA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 3lpm PUTATIVE
METHYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 12 LEU A   8
LEU A   6
ILE A  25
ALA A  93
ASP A  86
 None
 1.02A 3gwwA-3lpmA:
undetectable		 3gwwA-3lpmA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 3lpm PUTATIVE
METHYLTRANSFERASE
(Listeria
monocytogenes) 		4 / 8 MET A  87
SER A  91
ILE A  24
ARG A  23
 None
 0.92A 3sfeB-3lpmA:
undetectable
3sfeC-3lpmA:
undetectable		 3sfeB-3lpmA:
20.34
3sfeC-3lpmA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 3lpm PUTATIVE
METHYLTRANSFERASE
(Listeria
monocytogenes) 		4 / 6 GLY A  59
GLU A  79
ASP A 107
ASP A  55
 None
 0.90A 3vywC-3lpmA:
11.1		 3vywC-3lpmA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 3lpm PUTATIVE
METHYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 11 ALA A  37
ASP A  55
GLY A  59
ILE A  63
ASN A 126
 None
 0.62A 4dcmA-3lpmA:
20.6		 4dcmA-3lpmA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3lpm PUTATIVE
METHYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 12 SER A  44
ASP A  55
THR A 124
LEU A  97
ILE A  62
 None
 1.37A 4pghB-3lpmA:
11.8		 4pghB-3lpmA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 3lpm PUTATIVE
METHYLTRANSFERASE
(Listeria
monocytogenes) 		5 / 12 ASN A 126
ILE A  63
PRO A  64
ILE A  62
THR A 124
 None
 1.26A 4uroD-3lpmA:
undetectable		 4uroD-3lpmA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 3lpm PUTATIVE
METHYLTRANSFERASE
(Listeria
monocytogenes) 		4 / 6 LEU A 165
CYH A  57
CYH A 125
LEU A 108
 None
 1.42A 5hrqD-3lpmA:
undetectable
5hrqG-3lpmA:
undetectable
5hrqH-3lpmA:
undetectable		 5hrqD-3lpmA:
9.72
5hrqG-3lpmA:
8.95
5hrqH-3lpmA:
9.72