SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lpn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 3lpn RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermoplasma
volcanium) 		3 / 3 ARG A 167
THR A 263
VAL A 239
 None
 0.99A 1hxbA-3lpnA:
undetectable		 1hxbA-3lpnA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3lpn RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermoplasma
volcanium) 		4 / 5 ILE A 106
THR A 128
PHE A 136
TYR A 111
 None
 1.35A 3em0A-3lpnA:
undetectable		 3em0A-3lpnA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA315_0
(UNCHARACTERIZED
PROTEIN)		 3lpn RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermoplasma
volcanium) 		5 / 11 ARG A  95
THR A  56
LYS A 133
PHE A 136
ILE A 102
 None
 1.39A 3ijdA-3lpnA:
1.3		 3ijdA-3lpnA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 3lpn RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermoplasma
volcanium) 		4 / 6 VAL A 152
TYR A 148
TYR A 235
GLU A 257
 None
 1.15A 3q5sA-3lpnA:
undetectable		 3q5sA-3lpnA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3lpn RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermoplasma
volcanium) 		5 / 12 ASP A 211
LEU A 242
GLY A  88
SER A 104
GLN A  92
 None
None
None
None
APC  A 287 (-3.3A)
 1.33A 4djeA-3lpnA:
3.3		 4djeA-3lpnA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3lpn RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermoplasma
volcanium) 		4 / 8 ILE A 258
GLY A 241
THR A 263
VAL A 273
 None
 0.76A 4r20A-3lpnA:
undetectable		 4r20A-3lpnA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 3lpn RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermoplasma
volcanium) 		4 / 7 ILE A 212
HIS A 240
LEU A 242
GLY A  88
 None
 0.81A 4z69A-3lpnA:
undetectable		 4z69A-3lpnA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3lpn RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Thermoplasma
volcanium) 		5 / 10 SER A 247
GLY A 216
LEU A 242
GLY A 241
LEU A  37
 None
SO4  A 288 (-3.5A)
None
None
None
 1.43A 6hqbA-3lpnA:
undetectable
6hqbJ-3lpnA:
undetectable		 6hqbA-3lpnA:
14.84
6hqbJ-3lpnA:
9.62