SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lpp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 9 VAL A 434
GLY A 437
ILE A 431
TYR A 441
ILE A 480
 None
 1.17A 1cetA-3lppA:
undetectable		 1cetA-3lppA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 ILE A 709
ALA A 681
LEU A 669
ILE A 764
PRO A 765
 None
 0.96A 1drfA-3lppA:
undetectable		 1drfA-3lppA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWJ_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 9 PHE A 558
THR A 246
LEU A 263
VAL A 309
VAL A 144
 None
 1.44A 1iwjA-3lppA:
0.0		 1iwjA-3lppA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 6 ASP A 425
GLY A 426
THR A 428
PRO A 429
 None
NAG  A3001 (-4.2A)
None
None
 0.84A 1n4fA-3lppA:
undetectable		 1n4fA-3lppA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_F_BEZF511_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 5 GLU A 789
PHE A 688
ARG A 759
ALA A 727
 None
 1.38A 1oniE-3lppA:
0.0
1oniF-3lppA:
0.0		 1oniE-3lppA:
10.88
1oniF-3lppA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_F_BEZF511_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 5 TYR A 762
GLU A 789
PHE A 688
ALA A 727
 None
 1.09A 1oniE-3lppA:
0.0
1oniF-3lppA:
0.0		 1oniE-3lppA:
10.88
1oniF-3lppA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 6 PHE A 180
ALA A 198
TYR A 281
ILE A 205
 None
 1.17A 1oniH-3lppA:
1.7
1oniI-3lppA:
undetectable		 1oniH-3lppA:
10.88
1oniI-3lppA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 9 PHE A 558
THR A 246
LEU A 263
VAL A 309
VAL A 144
 None
 1.46A 1t86B-3lppA:
undetectable		 1t86B-3lppA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 7 LEU A 528
GLY A 530
THR A 554
ILE A 594
 None
 0.81A 2bdmA-3lppA:
undetectable		 2bdmA-3lppA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 11 GLY A 585
ASP A 571
ASN A 572
GLY A 598
PHE A 604
 None
TRS  A6001 ( 3.7A)
None
None
TRS  A6001 (-4.4A)
 1.41A 2hmaA-3lppA:
undetectable		 2hmaA-3lppA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 MET A 533
THR A 537
ALA A 540
ILE A 397
LEU A 393
 None
 1.05A 2jfaA-3lppA:
undetectable		 2jfaA-3lppA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 10 PHE A 115
THR A 182
THR A 117
VAL A 159
VAL A 170
 None
 1.39A 2qboA-3lppA:
undetectable		 2qboA-3lppA:
18.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		7 / 12 ASN A 239
ASP A 355
ILE A 356
ILE A 392
TRP A 435
ASP A 472
ARG A 555
 None
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 ( 4.6A)
TRS  A6001 (-3.2A)
TRS  A6001 ( 4.6A)
 1.24A 2qmjA-3lppA:
59.3		 2qmjA-3lppA:
57.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 ASN A 239
ASP A 394
ILE A 392
ILE A 356
ASP A 231
 None
None
None
TRS  A6001 ( 4.0A)
None
 1.36A 2qmjA-3lppA:
59.3		 2qmjA-3lppA:
57.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		10 / 12 ASP A 231
ASP A 355
ILE A 356
ILE A 392
TRP A 435
ASP A 472
ARG A 555
ASP A 571
PHE A 604
HIS A 629
 None
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 ( 4.6A)
TRS  A6001 (-3.2A)
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.26A 2qmjA-3lppA:
59.3		 2qmjA-3lppA:
57.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 ASP A 571
ASP A 394
ILE A 392
ILE A 356
ASP A 231
 TRS  A6001 ( 3.7A)
None
None
TRS  A6001 ( 4.0A)
None
 1.20A 2qmjA-3lppA:
59.3		 2qmjA-3lppA:
57.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QMJ_A_ACRA1001_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 6 TRP A 470
MET A 473
TRP A 568
THR A 573
 None
TRS  A6001 ( 3.7A)
None
None
 0.27A 2qmjA-3lppA:
59.3		 2qmjA-3lppA:
57.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 MET A 533
THR A 537
ALA A 540
ILE A 397
LEU A 393
 None
 0.99A 2qxsA-3lppA:
undetectable		 2qxsA-3lppA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_1
(ESTROGEN RECEPTOR)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 MET A 533
THR A 537
ALA A 540
ILE A 397
LEU A 393
 None
 1.07A 2qxsB-3lppA:
undetectable		 2qxsB-3lppA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		7 / 12 ASP A 231
GLN A 232
ASP A 355
ASP A 472
ASP A 571
PHE A 604
HIS A 629
 None
None
TRS  A6001 (-2.9A)
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.72A 2x2iA-3lppA:
33.6		 2x2iA-3lppA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		6 / 12 LEU A 233
GLN A 232
ASP A 355
ASP A 571
PHE A 604
HIS A 629
 None
None
TRS  A6001 (-2.9A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.93A 2x2iA-3lppA:
33.6		 2x2iA-3lppA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 6 TRP A 470
MET A 473
ARG A 555
TRP A 568
 None
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
None
 0.62A 2x2iA-3lppA:
33.6		 2x2iA-3lppA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		8 / 12 ASP A 231
GLN A 232
ASP A 355
ASP A 472
MET A 473
ASP A 571
PHE A 604
HIS A 629
 None
None
TRS  A6001 (-2.9A)
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.69A 2x2iB-3lppA:
33.6		 2x2iB-3lppA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		7 / 12 LEU A 233
GLN A 232
ASP A 355
ASP A 472
ASP A 571
PHE A 604
HIS A 629
 None
None
TRS  A6001 (-2.9A)
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.76A 2x2iB-3lppA:
33.6		 2x2iB-3lppA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		8 / 12 ASP A 231
GLN A 232
ASP A 355
ASP A 472
MET A 473
ASP A 571
PHE A 604
HIS A 629
 None
None
TRS  A6001 (-2.9A)
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.70A 2x2iC-3lppA:
33.6		 2x2iC-3lppA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 5 LEU A 233
TRP A 470
ARG A 555
TRP A 568
 None
None
TRS  A6001 ( 4.6A)
None
 0.84A 2x2iC-3lppA:
33.7		 2x2iC-3lppA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		8 / 12 ASP A 231
GLN A 232
ASP A 355
ASP A 472
MET A 473
ASP A 571
PHE A 604
HIS A 629
 None
None
TRS  A6001 (-2.9A)
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.69A 2x2iD-3lppA:
33.5		 2x2iD-3lppA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 5 LEU A 233
TRP A 470
ARG A 555
TRP A 568
 None
None
TRS  A6001 ( 4.6A)
None
 0.80A 2x2iD-3lppA:
33.5		 2x2iD-3lppA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 SER A 561
GLY A 243
THR A 229
GLU A 210
LEU A 569
 None
 1.12A 2zifA-3lppA:
undetectable		 2zifA-3lppA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		3 / 3 ARG A 230
ASP A 500
ASN A 239
 None
 0.85A 2zzmA-3lppA:
undetectable		 2zzmA-3lppA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 4 GLU A 252
GLY A 256
THR A 254
GLU A 690
 None
 1.18A 3e9xA-3lppA:
undetectable		 3e9xA-3lppA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IIZ_A_SAMA1501_0
(BIOTIN SYNTHETASE,
PUTATIVE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 GLN A 195
GLY A 185
ILE A  54
TYR A 193
LEU A 105
 None
 1.40A 3iizA-3lppA:
3.7		 3iizA-3lppA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 10 GLY A 735
GLU A 733
LEU A 758
LEU A 848
ILE A 784
 PEG  A7001 ( 4.0A)
None
None
None
PEG  A7001 (-4.5A)
 1.26A 3kvrA-3lppA:
undetectable		 3kvrA-3lppA:
14.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4W_A_MIGA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		11 / 12 ASP A 355
ILE A 356
ILE A 392
TRP A 435
TRP A 470
ASP A 472
MET A 473
TRP A 568
ASP A 571
PHE A 604
HIS A 629
 TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 ( 4.6A)
None
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.50A 3l4wA-3lppA:
50.3		 3l4wA-3lppA:
57.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 9 GLY A 735
GLU A 733
LEU A 758
LEU A 848
ILE A 784
 PEG  A7001 ( 4.0A)
None
None
None
PEG  A7001 (-4.5A)
 1.23A 3nbqA-3lppA:
undetectable		 3nbqA-3lppA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		3 / 3 TYR A 507
ASP A 514
ASP A 425
 None
 0.79A 3ou6B-3lppA:
undetectable		 3ou6B-3lppA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		11 / 12 ASP A 231
ASP A 355
ILE A 356
ILE A 392
TRP A 435
ASP A 472
ARG A 555
TRP A 568
ASP A 571
PHE A 604
HIS A 629
 None
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 ( 4.6A)
TRS  A6001 (-3.2A)
TRS  A6001 ( 4.6A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.40A 3phaA-3lppA:
37.6		 3phaA-3lppA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		10 / 12 ASP A 231
ASP A 355
ILE A 356
ILE A 392
TRP A 435
ASP A 472
ARG A 555
ASP A 571
PHE A 604
HIS A 629
 None
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 ( 4.6A)
TRS  A6001 (-3.2A)
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.36A 3phaB-3lppA:
25.8		 3phaB-3lppA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 ASP A 571
ASP A 394
ILE A 392
ILE A 356
ASP A 231
 TRS  A6001 ( 3.7A)
None
None
TRS  A6001 ( 4.0A)
None
 1.19A 3phaB-3lppA:
25.8		 3phaB-3lppA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 ASP A 600
ASP A 394
ILE A 392
ILE A 356
ASP A 571
 None
None
None
TRS  A6001 ( 4.0A)
TRS  A6001 ( 3.7A)
 1.38A 3phaB-3lppA:
25.8		 3phaB-3lppA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		10 / 12 ASP A 231
ASP A 355
ILE A 356
TRP A 435
ASP A 472
ARG A 555
TRP A 568
ASP A 571
PHE A 604
HIS A 629
 None
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
TRS  A6001 ( 4.6A)
TRS  A6001 (-3.2A)
TRS  A6001 ( 4.6A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.38A 3phaC-3lppA:
36.1		 3phaC-3lppA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		6 / 12 ASP A 231
ASP A 355
ILE A 392
ARG A 555
ASP A 571
PHE A 604
 None
TRS  A6001 (-2.9A)
None
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
 1.39A 3phaC-3lppA:
36.1		 3phaC-3lppA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		10 / 12 ASP A 231
ASP A 355
ILE A 356
TRP A 435
ASP A 472
MET A 473
ARG A 555
ASP A 571
PHE A 604
HIS A 629
 None
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
TRS  A6001 ( 4.6A)
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.33A 3phaD-3lppA:
36.3		 3phaD-3lppA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		6 / 12 ASP A 231
ASP A 355
ILE A 392
MET A 473
ASP A 571
PHE A 604
 None
TRS  A6001 (-2.9A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
 1.45A 3phaD-3lppA:
36.3		 3phaD-3lppA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_A_ACRA664_1
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		7 / 12 ASP A 355
ILE A 392
MET A 473
ARG A 555
ASP A 571
PHE A 604
HIS A 629
 TRS  A6001 (-2.9A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 1.41A 3pocA-3lppA:
36.1		 3pocA-3lppA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_A_ACRA664_1
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		11 / 12 TRP A 327
ASP A 355
ILE A 356
ILE A 392
TRP A 435
MET A 473
ARG A 555
TRP A 568
ASP A 571
PHE A 604
HIS A 629
 TRS  A6001 ( 3.8A)
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.33A 3pocA-3lppA:
36.1		 3pocA-3lppA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_A_ACRA664_1
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		8 / 12 TRP A 327
ASP A 355
ILE A 356
ILE A 392
TRP A 435
TRP A 470
PHE A 604
HIS A 629
 TRS  A6001 ( 3.8A)
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 ( 4.6A)
None
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.85A 3pocA-3lppA:
36.1		 3pocA-3lppA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB664_1
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		11 / 12 TRP A 327
ASP A 355
ILE A 356
ILE A 392
TRP A 435
MET A 473
ARG A 555
TRP A 568
ASP A 571
PHE A 604
HIS A 629
 TRS  A6001 ( 3.8A)
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.38A 3pocB-3lppA:
38.0		 3pocB-3lppA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB664_1
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		8 / 12 TRP A 327
ASP A 355
ILE A 356
ILE A 392
TRP A 435
TRP A 470
PHE A 604
HIS A 629
 TRS  A6001 ( 3.8A)
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 ( 4.6A)
None
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.89A 3pocB-3lppA:
38.0		 3pocB-3lppA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		3 / 3 LEU A 888
ARG A 858
ASN A 863
 None
 0.56A 3qxvD-3lppA:
undetectable		 3qxvD-3lppA:
9.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		10 / 12 ASP A 231
ASP A 355
ILE A 392
TRP A 435
ASP A 472
MET A 473
ARG A 555
ASP A 571
PHE A 604
HIS A 629
 None
TRS  A6001 (-2.9A)
None
TRS  A6001 ( 4.6A)
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.46A 3topA-3lppA:
48.7		 3topA-3lppA:
41.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 ASP A 231
TRP A 435
MET A 473
ASP A 571
PHE A 604
 None
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
 1.24A 3topA-3lppA:
48.7		 3topA-3lppA:
41.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 ASP A 600
ASP A 394
ILE A 356
ASP A 355
ASP A 571
 None
None
TRS  A6001 ( 4.0A)
TRS  A6001 (-2.9A)
TRS  A6001 ( 3.7A)
 1.48A 3topA-3lppA:
48.7		 3topA-3lppA:
41.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TOP_A_ACRA1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		6 / 12 PRO A 234
ASP A 355
ILE A 392
ASP A 472
PHE A 604
HIS A 629
 None
TRS  A6001 (-2.9A)
None
TRS  A6001 (-3.2A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 1.19A 3topA-3lppA:
48.7		 3topA-3lppA:
41.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TOP_A_ACRA1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 5 ILE A 356
TRP A 470
TRP A 568
THR A 573
 TRS  A6001 ( 4.0A)
None
None
None
 0.22A 3topA-3lppA:
48.7		 3topA-3lppA:
41.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TOP_A_ACRA1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 5 TRP A 470
LYS A 509
TRP A 568
THR A 573
 None
 1.14A 3topA-3lppA:
48.7		 3topA-3lppA:
41.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TOP_B_ACRB1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		10 / 12 ASP A 231
ASP A 355
ILE A 392
TRP A 435
ASP A 472
MET A 473
ARG A 555
ASP A 571
PHE A 604
HIS A 629
 None
TRS  A6001 (-2.9A)
None
TRS  A6001 ( 4.6A)
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.45A 3topB-3lppA:
48.7		 3topB-3lppA:
41.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TOP_B_ACRB1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		7 / 12 ASP A 231
ASP A 472
LYS A 509
ARG A 555
ASP A 571
PHE A 604
HIS A 629
 None
TRS  A6001 (-3.2A)
None
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.95A 3topB-3lppA:
48.7		 3topB-3lppA:
41.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TOP_B_ACRB1_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 ASP A 600
ASP A 394
ILE A 356
ASP A 355
ASP A 571
 None
None
TRS  A6001 ( 4.0A)
TRS  A6001 (-2.9A)
TRS  A6001 ( 3.7A)
 1.47A 3topB-3lppA:
48.7		 3topB-3lppA:
41.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 GLN A 245
GLY A 243
ALA A 599
GLY A 598
ASN A 572
 None
 1.14A 3v3oB-3lppA:
undetectable		 3v3oB-3lppA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		3 / 3 THR A 224
ASN A 238
GLU A 270
 None
 0.59A 3v4tA-3lppA:
undetectable
3v4tC-3lppA:
undetectable		 3v4tA-3lppA:
18.23
3v4tC-3lppA:
18.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		10 / 12 ASP A 231
ASP A 355
ILE A 392
TRP A 470
ASP A 472
MET A 473
ARG A 555
ASP A 571
PHE A 604
HIS A 629
 None
TRS  A6001 (-2.9A)
None
None
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.26A 3w37A-3lppA:
51.9		 3w37A-3lppA:
35.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W37_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 5 TRP A 327
ILE A 356
TRP A 435
TRP A 568
 TRS  A6001 ( 3.8A)
TRS  A6001 ( 4.0A)
TRS  A6001 ( 4.6A)
None
 0.25A 3w37A-3lppA:
51.9		 3w37A-3lppA:
35.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		3 / 3 ASP A 524
GLY A 286
TYR A 523
 None
 0.79A 3w9tC-3lppA:
undetectable		 3w9tC-3lppA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		3 / 3 ASP A 524
GLY A 286
TYR A 523
 None
 0.79A 3w9tG-3lppA:
undetectable		 3w9tG-3lppA:
19.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		9 / 12 ASP A 231
ASP A 355
ILE A 392
TRP A 470
ASP A 472
ARG A 555
ASP A 571
PHE A 604
HIS A 629
 None
TRS  A6001 (-2.9A)
None
None
TRS  A6001 (-3.2A)
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.28A 3welA-3lppA:
51.9		 3welA-3lppA:
35.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 6 TRP A 327
ILE A 356
TRP A 435
MET A 473
TRP A 568
 TRS  A6001 ( 3.8A)
TRS  A6001 ( 4.0A)
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
None
 0.32A 3welA-3lppA:
51.9		 3welA-3lppA:
35.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		9 / 12 ASP A 231
ASP A 355
ILE A 356
ASP A 472
MET A 473
ARG A 555
ASP A 571
PHE A 604
HIS A 629
 None
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.32A 3wemA-3lppA:
51.5		 3wemA-3lppA:
35.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		7 / 12 ASP A 231
ASP A 355
ILE A 392
MET A 473
ASP A 571
PHE A 604
HIS A 629
 None
TRS  A6001 (-2.9A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 1.47A 3wemA-3lppA:
51.5		 3wemA-3lppA:
35.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEM_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 5 TRP A 327
TRP A 435
TRP A 470
TRP A 568
 TRS  A6001 ( 3.8A)
TRS  A6001 ( 4.6A)
None
None
 0.38A 3wemA-3lppA:
51.5		 3wemA-3lppA:
35.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		10 / 12 ASP A 231
ASP A 355
ILE A 356
TRP A 470
ASP A 472
MET A 473
ARG A 555
ASP A 571
PHE A 604
HIS A 629
 None
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.29A 3wenA-3lppA:
51.5		 3wenA-3lppA:
35.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		7 / 12 ASP A 231
ASP A 355
ILE A 392
MET A 473
ASP A 571
PHE A 604
HIS A 629
 None
TRS  A6001 (-2.9A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 1.48A 3wenA-3lppA:
51.5		 3wenA-3lppA:
35.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		9 / 12 ASP A 231
ASP A 355
ILE A 356
TRP A 470
ASP A 472
ARG A 555
ASP A 571
PHE A 604
HIS A 629
 None
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 (-3.2A)
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.29A 3weoA-3lppA:
49.2		 3weoA-3lppA:
35.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		6 / 12 ASP A 231
ASP A 355
ILE A 392
ASP A 571
PHE A 604
HIS A 629
 None
TRS  A6001 (-2.9A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 1.44A 3weoA-3lppA:
49.2		 3weoA-3lppA:
35.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 6 TRP A 327
ILE A 392
TRP A 435
MET A 473
TRP A 568
 TRS  A6001 ( 3.8A)
None
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
None
 0.31A 3weoA-3lppA:
49.2		 3weoA-3lppA:
35.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 11 GLN A 245
GLY A 243
ALA A 599
GLY A 598
ASN A 572
 None
 1.13A 4a6nA-3lppA:
undetectable		 4a6nA-3lppA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 ASP A 355
ILE A 356
ASP A 571
PHE A 604
HIS A 629
 TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 1.40A 4b9zA-3lppA:
38.5		 4b9zA-3lppA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		7 / 12 ASP A 355
ILE A 392
ASP A 472
ARG A 555
ASP A 571
PHE A 604
HIS A 629
 TRS  A6001 (-2.9A)
None
TRS  A6001 (-3.2A)
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.36A 4b9zA-3lppA:
38.5		 4b9zA-3lppA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		7 / 12 ASP A 355
ILE A 392
ASP A 472
GLU A 475
ARG A 555
ASP A 571
HIS A 629
 TRS  A6001 (-2.9A)
None
TRS  A6001 (-3.2A)
None
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.2A)
 1.48A 4b9zA-3lppA:
38.5		 4b9zA-3lppA:
25.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 7 PHE A 842
ASN A 889
GLY A 891
PHE A 797
 None
 0.87A 4ejjA-3lppA:
undetectable		 4ejjA-3lppA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 7 PHE A 842
ASN A 889
GLY A 891
PHE A 797
 None
 0.93A 4ejjB-3lppA:
undetectable		 4ejjB-3lppA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 9 PHE A 558
THR A 246
LEU A 263
VAL A 309
VAL A 144
 None
 1.43A 4ek1B-3lppA:
undetectable		 4ek1B-3lppA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 ASP A 472
ASP A 231
ASP A 600
GLU A 210
HIS A 567
 TRS  A6001 (-3.2A)
None
None
None
None
 1.36A 4feuA-3lppA:
1.1
4feuB-3lppA:
0.0		 4feuA-3lppA:
16.67
4feuB-3lppA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 11 HIS A 567
ASP A 472
ASP A 231
ASP A 600
GLU A 210
 None
TRS  A6001 (-3.2A)
None
None
None
 1.43A 4fevE-3lppA:
0.0		 4fevE-3lppA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 11 SER A 266
LEU A 293
GLY A 560
PHE A 558
VAL A 144
 None
 1.10A 4fogC-3lppA:
undetectable		 4fogC-3lppA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		3 / 3 PHE A 688
VAL A 684
GLU A 700
 None
 0.69A 4fvqA-3lppA:
undetectable		 4fvqA-3lppA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G5J_A_0WMA1102_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 7 PHE A 444
TYR A 529
ILE A 511
PRO A 442
 None
 1.14A 4g5jA-3lppA:
undetectable		 4g5jA-3lppA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 11 ASP A 472
ASP A 231
ASP A 600
GLU A 210
HIS A 567
 TRS  A6001 (-3.2A)
None
None
None
None
 1.50A 4gkhC-3lppA:
1.6
4gkhD-3lppA:
1.3		 4gkhC-3lppA:
16.67
4gkhD-3lppA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_H_KANH301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 10 HIS A 567
ASP A 472
ASP A 231
ASP A 600
GLU A 210
 None
TRS  A6001 (-3.2A)
None
None
None
 1.40A 4gkhG-3lppA:
1.3
4gkhH-3lppA:
0.6		 4gkhG-3lppA:
16.67
4gkhH-3lppA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_L_KANL301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 10 HIS A 567
ASP A 472
ASP A 231
ASP A 600
GLU A 210
 None
TRS  A6001 (-3.2A)
None
None
None
 1.38A 4gkhK-3lppA:
0.8
4gkhL-3lppA:
0.9		 4gkhK-3lppA:
16.67
4gkhL-3lppA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 11 HIS A 567
ASP A 472
ASP A 231
ASP A 600
GLU A 210
 None
TRS  A6001 (-3.2A)
None
None
None
 1.41A 4gkiC-3lppA:
0.0
4gkiD-3lppA:
0.6		 4gkiC-3lppA:
16.67
4gkiD-3lppA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_H_KANH301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 10 HIS A 567
ASP A 472
ASP A 231
ASP A 600
GLU A 210
 None
TRS  A6001 (-3.2A)
None
None
None
 1.42A 4gkiG-3lppA:
0.6
4gkiH-3lppA:
1.8		 4gkiG-3lppA:
16.67
4gkiH-3lppA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JXC_A_SAMA402_0
(FEFE-HYDROGENASE
MATURASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 GLN A 195
GLY A 185
ILE A  54
TYR A 193
LEU A 105
 None
 1.40A 4jxcA-3lppA:
4.5		 4jxcA-3lppA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 10 VAL A 597
TYR A 623
GLY A 570
SER A 582
GLY A 585
 None
 1.40A 4mmcA-3lppA:
undetectable		 4mmcA-3lppA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_A_EF2A151_1
(CEREBLON ISOFORM 4)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 7 ASN A 319
PRO A 315
PHE A 670
TYR A 660
 None
 1.47A 4v2yA-3lppA:
undetectable		 4v2yA-3lppA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_A_LVYA151_1
(CEREBLON ISOFORM 4)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 7 ASN A 319
PRO A 315
PHE A 670
TYR A 660
 None
 1.47A 4v30A-3lppA:
undetectable		 4v30A-3lppA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 7 PHE A 589
ILE A 594
GLY A 243
THR A 229
 None
 0.83A 4zdzA-3lppA:
undetectable		 4zdzA-3lppA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 7 PHE A 589
ILE A 594
GLY A 243
THR A 229
 None
 0.83A 4ze3A-3lppA:
undetectable		 4ze3A-3lppA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_B_EF2B151_1
(CEREBLON ISOFORM 4)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 7 ASN A 319
PRO A 315
PHE A 670
TYR A 660
 None
 1.49A 5amkB-3lppA:
undetectable		 5amkB-3lppA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 7 ILE A 827
PHE A 842
VAL A 845
ILE A 847
 None
 0.77A 5bmvC-3lppA:
undetectable		 5bmvC-3lppA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECO_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 6 THR A 182
ALA A 198
VAL A 279
TYR A 281
 None
 0.97A 5ecoA-3lppA:
undetectable		 5ecoA-3lppA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 PRO A 683
HIS A 213
HIS A 218
PHE A 216
LEU A 591
 None
 1.09A 5eeiA-3lppA:
undetectable		 5eeiA-3lppA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 PRO A 683
HIS A 213
HIS A 218
PHE A 216
LEU A 591
 None
 1.10A 5eeiB-3lppA:
undetectable		 5eeiB-3lppA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 6 TYR A 242
GLY A 585
GLU A 588
ASP A 698
 None
 1.27A 5emlA-3lppA:
4.3		 5emlA-3lppA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 8 PHE A 589
ILE A 594
GLY A 243
THR A 229
 None
 0.84A 5esfA-3lppA:
undetectable		 5esfA-3lppA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 ALA A 606
PHE A 589
ILE A 594
GLY A 243
THR A 229
 None
 1.21A 5eshA-3lppA:
undetectable		 5eshA-3lppA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 8 PHE A 589
ILE A 594
GLY A 243
THR A 229
 None
 0.81A 5esjA-3lppA:
undetectable		 5esjA-3lppA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 7 PHE A 589
ILE A 594
GLY A 243
THR A 229
 None
 0.83A 5esmA-3lppA:
undetectable		 5esmA-3lppA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		3 / 3 PRO A 725
ILE A 784
SER A 694
 None
PEG  A7001 (-4.5A)
None
 0.74A 5fsaA-3lppA:
undetectable		 5fsaA-3lppA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS1_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 8 PHE A 589
ILE A 594
GLY A 243
THR A 229
 None
 0.84A 5hs1A-3lppA:
undetectable		 5hs1A-3lppA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEF_A_NBVA1005_1
(NEUTRAL
ALPHA-GLUCOSIDASE AB)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		11 / 12 TRP A 327
ASP A 355
ILE A 356
ILE A 392
TRP A 470
ASP A 472
MET A 473
PHE A 479
ASP A 571
PHE A 604
HIS A 629
 TRS  A6001 ( 3.8A)
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
None
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.46A 5iefA-3lppA:
42.7		 5iefA-3lppA:
29.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEF_A_NBVA1005_2
(NEUTRAL
ALPHA-GLUCOSIDASE AB)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 4 ARG A 555
TRP A 568
ASP A 600
ARG A 627
 TRS  A6001 ( 4.6A)
None
None
None
 0.24A 5iefA-3lppA:
42.7		 5iefA-3lppA:
29.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 5 ARG A 172
LEU A 179
PHE A 180
LEU A 294
 None
 1.24A 5iy5P-3lppA:
undetectable
5iy5W-3lppA:
undetectable		 5iy5P-3lppA:
13.92
5iy5W-3lppA:
5.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 LEU A 881
ILE A 827
PHE A 842
VAL A 845
ILE A 847
 None
 0.78A 5j2tC-3lppA:
undetectable		 5j2tC-3lppA:
18.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NN6_A_MIGA1013_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		10 / 12 TRP A 327
ASP A 355
ILE A 392
TRP A 435
TRP A 470
ASP A 472
MET A 473
TRP A 568
PHE A 604
HIS A 629
 TRS  A6001 ( 3.8A)
TRS  A6001 (-2.9A)
None
TRS  A6001 ( 4.6A)
None
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
None
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.68A 5nn6A-3lppA:
52.1		 5nn6A-3lppA:
42.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NN6_A_MIGA1013_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		10 / 12 TRP A 327
ASP A 355
ILE A 392
TRP A 435
TRP A 470
ASP A 472
TRP A 568
ASP A 571
PHE A 604
HIS A 629
 TRS  A6001 ( 3.8A)
TRS  A6001 (-2.9A)
None
TRS  A6001 ( 4.6A)
None
TRS  A6001 (-3.2A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.62A 5nn6A-3lppA:
52.1		 5nn6A-3lppA:
42.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 ASP A 231
ASP A 355
ILE A 356
ASP A 571
PHE A 604
 None
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
 1.49A 5nn8A-3lppA:
51.1		 5nn8A-3lppA:
42.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		10 / 12 ASP A 231
ASP A 355
ILE A 392
TRP A 435
TRP A 470
ASP A 472
ARG A 555
ASP A 571
PHE A 604
HIS A 629
 None
TRS  A6001 (-2.9A)
None
TRS  A6001 ( 4.6A)
None
TRS  A6001 (-3.2A)
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.36A 5nn8A-3lppA:
51.1		 5nn8A-3lppA:
42.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		6 / 12 ILE A 392
TRP A 435
TRP A 470
ASP A 472
ASP A 571
LEU A 233
 None
TRS  A6001 ( 4.6A)
None
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
None
 1.36A 5nn8A-3lppA:
51.1		 5nn8A-3lppA:
42.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_A_EF2A202_0
(CEREBLON ISOFORM 4)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 7 ASN A 319
PRO A 315
PHE A 670
TYR A 660
 None
 1.48A 5oh1A-3lppA:
undetectable		 5oh1A-3lppA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_B_EF2B202_0
(CEREBLON ISOFORM 4)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 7 ASN A 319
PRO A 315
PHE A 670
TYR A 660
 None
 1.45A 5oh1B-3lppA:
undetectable		 5oh1B-3lppA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHG_C_RFPC1201_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 LEU A 187
ASP A 191
ARG A 136
ASN A 265
ILE A 287
 None
 1.33A 5uhgC-3lppA:
1.3		 5uhgC-3lppA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UTU_H_ADNH503_2
(ADENOSYLHOMOCYSTEINA
SE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 5 THR A 679
GLU A 687
HIS A 757
LEU A 707
 None
 1.29A 5utuH-3lppA:
undetectable		 5utuH-3lppA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 6 ARG A 172
LEU A 179
PHE A 180
LEU A 294
 None
 1.11A 5x19P-3lppA:
undetectable		 5x19P-3lppA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 5 ARG A 172
LEU A 179
PHE A 180
LEU A 294
 None
 1.17A 5x1fC-3lppA:
undetectable
5x1fJ-3lppA:
undetectable		 5x1fC-3lppA:
13.92
5x1fJ-3lppA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1401_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		7 / 10 TRP A 470
ASP A 472
ARG A 555
TRP A 568
ASP A 571
PHE A 604
HIS A 629
 None
TRS  A6001 (-3.2A)
TRS  A6001 ( 4.6A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.59A 5x7pA-3lppA:
19.3		 5x7pA-3lppA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 5 ARG A 172
LEU A 179
PHE A 180
LEU A 294
 None
 1.22A 5xdxC-3lppA:
undetectable
5xdxJ-3lppA:
undetectable		 5xdxC-3lppA:
13.92
5xdxJ-3lppA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 5 ARG A 172
LEU A 179
PHE A 180
LEU A 294
 None
 1.25A 5xdxP-3lppA:
undetectable
5xdxW-3lppA:
undetectable		 5xdxP-3lppA:
13.92
5xdxW-3lppA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 8 GLY A 849
ASN A 878
SER A 877
GLN A 879
 None
 0.93A 5xu8A-3lppA:
undetectable		 5xu8A-3lppA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 TRP A 703
ILE A 583
HIS A 567
LEU A 569
GLY A 585
 None
 1.39A 6bp4B-3lppA:
undetectable		 6bp4B-3lppA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		6 / 12 ASP A 231
ILE A 392
MET A 473
ARG A 555
PHE A 604
HIS A 629
 None
None
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 1.18A 6c9xA-3lppA:
37.5		 6c9xA-3lppA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		11 / 12 ASP A 231
TRP A 327
ILE A 356
ILE A 392
TRP A 435
ASP A 472
MET A 473
ARG A 555
TRP A 568
PHE A 604
HIS A 629
 None
TRS  A6001 ( 3.8A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 ( 4.6A)
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
None
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.35A 6c9xA-3lppA:
37.5		 6c9xA-3lppA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		8 / 12 TRP A 327
ILE A 356
ILE A 392
TRP A 435
TRP A 470
TRP A 568
PHE A 604
HIS A 629
 TRS  A6001 ( 3.8A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 ( 4.6A)
None
None
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.86A 6c9xA-3lppA:
37.5		 6c9xA-3lppA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		6 / 12 ASP A 231
ILE A 392
MET A 473
ARG A 555
PHE A 604
HIS A 629
 None
None
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 1.17A 6c9xB-3lppA:
37.7		 6c9xB-3lppA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		11 / 12 ASP A 231
TRP A 327
ILE A 356
ILE A 392
TRP A 435
ASP A 472
MET A 473
ARG A 555
TRP A 568
PHE A 604
HIS A 629
 None
TRS  A6001 ( 3.8A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 ( 4.6A)
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
None
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.36A 6c9xB-3lppA:
37.7		 6c9xB-3lppA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		8 / 12 TRP A 327
ILE A 356
ILE A 392
TRP A 435
TRP A 470
TRP A 568
PHE A 604
HIS A 629
 TRS  A6001 ( 3.8A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 ( 4.6A)
None
None
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.86A 6c9xB-3lppA:
37.7		 6c9xB-3lppA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		10 / 12 ILE A 356
ILE A 392
TRP A 435
ASP A 472
MET A 473
ARG A 555
TRP A 568
ASP A 571
PHE A 604
HIS A 629
 TRS  A6001 ( 4.0A)
None
TRS  A6001 ( 4.6A)
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.37A 6c9zA-3lppA:
36.0		 6c9zA-3lppA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		7 / 12 ILE A 356
ILE A 392
TRP A 435
TRP A 470
TRP A 568
PHE A 604
HIS A 629
 TRS  A6001 ( 4.0A)
None
TRS  A6001 ( 4.6A)
None
None
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.94A 6c9zA-3lppA:
36.0		 6c9zA-3lppA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 ILE A 356
MET A 473
ASP A 571
PHE A 604
HIS A 629
 TRS  A6001 ( 4.0A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 1.46A 6c9zA-3lppA:
36.0		 6c9zA-3lppA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		10 / 12 ASP A 231
ILE A 356
ILE A 392
TRP A 435
ASP A 472
MET A 473
ARG A 555
TRP A 568
PHE A 604
HIS A 629
 None
TRS  A6001 ( 4.0A)
None
TRS  A6001 ( 4.6A)
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
None
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.36A 6c9zB-3lppA:
37.3		 6c9zB-3lppA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 ASP A 231
ILE A 356
MET A 473
PHE A 604
HIS A 629
 None
TRS  A6001 ( 4.0A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 1.43A 6c9zB-3lppA:
37.3		 6c9zB-3lppA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 ASP A 231
ILE A 392
MET A 473
ARG A 555
PHE A 604
 None
None
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
TRS  A6001 (-4.4A)
 1.02A 6c9zB-3lppA:
37.3		 6c9zB-3lppA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		7 / 12 ILE A 356
ILE A 392
TRP A 435
TRP A 470
TRP A 568
PHE A 604
HIS A 629
 TRS  A6001 ( 4.0A)
None
TRS  A6001 ( 4.6A)
None
None
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.93A 6c9zB-3lppA:
37.3		 6c9zB-3lppA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		7 / 12 ASP A 355
ILE A 392
MET A 473
ARG A 555
ASP A 571
PHE A 604
HIS A 629
 TRS  A6001 (-2.9A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 1.40A 6ca1A-3lppA:
36.1		 6ca1A-3lppA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		11 / 12 TRP A 327
ASP A 355
ILE A 356
ILE A 392
ASP A 472
MET A 473
ARG A 555
TRP A 568
ASP A 571
PHE A 604
HIS A 629
 TRS  A6001 ( 3.8A)
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.40A 6ca1A-3lppA:
36.1		 6ca1A-3lppA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		8 / 12 TRP A 327
ASP A 355
ILE A 356
ILE A 392
TRP A 470
TRP A 568
PHE A 604
HIS A 629
 TRS  A6001 ( 3.8A)
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
None
None
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.83A 6ca1A-3lppA:
36.1		 6ca1A-3lppA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		7 / 12 ASP A 355
ILE A 392
MET A 473
ARG A 555
ASP A 571
PHE A 604
HIS A 629
 TRS  A6001 (-2.9A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 1.42A 6ca1B-3lppA:
36.4		 6ca1B-3lppA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		11 / 12 TRP A 327
ASP A 355
ILE A 356
ILE A 392
ASP A 472
MET A 473
ARG A 555
TRP A 568
ASP A 571
PHE A 604
HIS A 629
 TRS  A6001 ( 3.8A)
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.39A 6ca1B-3lppA:
36.4		 6ca1B-3lppA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		8 / 12 TRP A 327
ASP A 355
ILE A 356
ILE A 392
TRP A 470
TRP A 568
PHE A 604
HIS A 629
 TRS  A6001 ( 3.8A)
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
None
None
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.83A 6ca1B-3lppA:
36.4		 6ca1B-3lppA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		10 / 12 ASP A 355
ILE A 356
ILE A 392
ASP A 472
MET A 473
ARG A 555
TRP A 568
ASP A 571
PHE A 604
HIS A 629
 TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.43A 6ca3A-3lppA:
37.6		 6ca3A-3lppA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		7 / 12 ASP A 355
ILE A 356
ILE A 392
TRP A 470
TRP A 568
PHE A 604
HIS A 629
 TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
None
None
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.90A 6ca3A-3lppA:
37.6		 6ca3A-3lppA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		10 / 12 ASP A 355
ILE A 356
ILE A 392
ASP A 472
MET A 473
ARG A 555
TRP A 568
ASP A 571
PHE A 604
HIS A 629
 TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.43A 6ca3B-3lppA:
36.0		 6ca3B-3lppA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		8 / 12 ASP A 355
ILE A 356
ILE A 392
TRP A 435
ASP A 472
TRP A 568
PHE A 604
HIS A 629
 TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 ( 4.6A)
TRS  A6001 (-3.2A)
None
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.67A 6ca3B-3lppA:
36.0		 6ca3B-3lppA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		8 / 12 ASP A 355
ILE A 356
ILE A 392
TRP A 435
TRP A 470
TRP A 568
PHE A 604
HIS A 629
 TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 ( 4.6A)
None
None
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 1.12A 6ca3B-3lppA:
36.0		 6ca3B-3lppA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		4 / 5 THR A 284
THR A 510
GLN A 522
ASP A 231
 None
 1.45A 6ecxA-3lppA:
undetectable		 6ecxA-3lppA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_0
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 3lpp SUCRASE-ISOMALTASE
(Homo
sapiens) 		5 / 12 TRP A 453
THR A 537
VAL A 541
VAL A 544
ASP A 472
 None
None
None
None
TRS  A6001 (-3.2A)
 1.19A 6iblA-3lppA:
undetectable		 6iblA-3lppA:
17.79