SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lps'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AJ6_A_NOVA1_1
(GYRASE)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		7 / 9 ASN A  86
GLU A  90
ASP A 113
ARG A 116
PRO A 119
ILE A 134
THR A 207
 NOV  A 901 (-4.0A)
NOV  A 901 (-3.8A)
NOV  A 901 (-3.5A)
NOV  A 901 (-3.4A)
NOV  A 901 (-4.5A)
NOV  A 901 ( 4.9A)
NOV  A 901 ( 4.2A)
 0.51A 1aj6A-3lpsA:
27.3		 1aj6A-3lpsA:
32.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		9 / 12 ASP A  89
GLU A  90
ASP A 113
ARG A 116
PRO A 119
ASP A 121
ILE A 134
ARG A 176
THR A 207
 NOV  A 901 ( 4.8A)
NOV  A 901 (-3.8A)
NOV  A 901 (-3.5A)
NOV  A 901 (-3.4A)
NOV  A 901 (-4.5A)
NOV  A 901 (-2.6A)
NOV  A 901 ( 4.9A)
NOV  A 901 (-2.5A)
NOV  A 901 ( 4.2A)
 0.45A 1kijA-3lpsA:
39.5		 1kijA-3lpsA:
36.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		9 / 12 ASN A  86
GLU A  90
ASP A 113
ARG A 116
PRO A 119
ASP A 121
ILE A 134
ARG A 176
THR A 207
 NOV  A 901 (-4.0A)
NOV  A 901 (-3.8A)
NOV  A 901 (-3.5A)
NOV  A 901 (-3.4A)
NOV  A 901 (-4.5A)
NOV  A 901 (-2.6A)
NOV  A 901 ( 4.9A)
NOV  A 901 (-2.5A)
NOV  A 901 ( 4.2A)
 0.53A 1kijB-3lpsA:
39.2		 1kijB-3lpsA:
36.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		5 / 10 GLY A 320
HIS A 319
ALA A 385
ALA A 386
ILE A 389
 None
 1.04A 1likA-3lpsA:
undetectable		 1likA-3lpsA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		5 / 12 PHE A 397
GLY A 284
SER A 285
ALA A 297
ALA A 296
 None
 1.26A 1nw5A-3lpsA:
undetectable		 1nw5A-3lpsA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		5 / 12 ALA A 396
ALA A 393
LEU A 380
GLY A 284
LEU A 365
 None
 1.23A 1qabF-3lpsA:
undetectable		 1qabF-3lpsA:
19.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S14_A_NOVA1300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		12 / 12 ASN A  86
SER A  87
ASP A  89
GLU A  90
ASP A 113
ARG A 116
MET A 118
PRO A 119
ASP A 121
ILE A 134
ARG A 176
THR A 207
 NOV  A 901 (-4.0A)
NOV  A 901 (-3.3A)
NOV  A 901 ( 4.8A)
NOV  A 901 (-3.8A)
NOV  A 901 (-3.5A)
NOV  A 901 (-3.4A)
NOV  A 901 (-3.7A)
NOV  A 901 (-4.5A)
NOV  A 901 (-2.6A)
NOV  A 901 ( 4.9A)
NOV  A 901 (-2.5A)
NOV  A 901 ( 4.2A)
 0.46A 1s14A-3lpsA:
27.5		 1s14A-3lpsA:
41.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1S14_B_NOVB2300_1
(TOPOISOMERASE IV
SUBUNIT B)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		11 / 12 ASN A  86
SER A  87
ASP A  89
GLU A  90
ASP A 113
ARG A 116
MET A 118
PRO A 119
ASP A 121
ILE A 134
ARG A 176
 NOV  A 901 (-4.0A)
NOV  A 901 (-3.3A)
NOV  A 901 ( 4.8A)
NOV  A 901 (-3.8A)
NOV  A 901 (-3.5A)
NOV  A 901 (-3.4A)
NOV  A 901 (-3.7A)
NOV  A 901 (-4.5A)
NOV  A 901 (-2.6A)
NOV  A 901 ( 4.9A)
NOV  A 901 (-2.5A)
 0.55A 1s14B-3lpsA:
29.8		 1s14B-3lpsA:
41.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		5 / 11 GLU A 291
GLY A 391
GLU A 390
LEU A 365
GLY A 325
 None
 1.33A 2fn1A-3lpsA:
undetectable		 2fn1A-3lpsA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		5 / 11 LEU A 380
GLY A 320
ILE A 389
VAL A 293
VAL A 311
 None
 0.98A 2kawA-3lpsA:
undetectable		 2kawA-3lpsA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		4 / 7 VAL A 170
GLY A 188
ALA A 165
LEU A 166
 None
 0.90A 2wekB-3lpsA:
undetectable		 2wekB-3lpsA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		5 / 12 VAL A 348
CYH A 338
LEU A 350
GLN A 413
ALA A 412
 None
 1.05A 3a35A-3lpsA:
undetectable		 3a35A-3lpsA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		5 / 12 VAL A 348
CYH A 338
LEU A 350
GLN A 413
ALA A 412
 None
 1.10A 3a35B-3lpsA:
undetectable		 3a35B-3lpsA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		5 / 12 VAL A 348
CYH A 338
LEU A 350
GLN A 413
ALA A 412
 None
 1.08A 3a3bA-3lpsA:
undetectable		 3a3bA-3lpsA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		4 / 4 LEU A  79
ALA A 165
VAL A  63
PRO A  67
 None
 1.10A 3gv1B-3lpsA:
undetectable		 3gv1B-3lpsA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		5 / 10 PHE A 223
PHE A 218
LEU A 209
VAL A 160
VAL A 170
 None
 1.25A 3u9fE-3lpsA:
undetectable		 3u9fE-3lpsA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		5 / 10 PHE A 223
PHE A 218
LEU A 209
VAL A 160
VAL A 170
 None
 1.27A 3u9fK-3lpsA:
undetectable		 3u9fK-3lpsA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		5 / 12 LEU A 281
GLY A 262
GLY A 241
LEU A 267
ASP A 265
 None
 1.15A 4blvA-3lpsA:
undetectable		 4blvA-3lpsA:
23.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_A_NOVA2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		11 / 11 ASN A  86
SER A  87
ASP A  89
GLU A  90
ASP A 113
ARG A 116
MET A 118
PRO A 119
ILE A 134
ARG A 176
THR A 207
 NOV  A 901 (-4.0A)
NOV  A 901 (-3.3A)
NOV  A 901 ( 4.8A)
NOV  A 901 (-3.8A)
NOV  A 901 (-3.5A)
NOV  A 901 (-3.4A)
NOV  A 901 (-3.7A)
NOV  A 901 (-4.5A)
NOV  A 901 ( 4.9A)
NOV  A 901 (-2.5A)
NOV  A 901 ( 4.2A)
 0.69A 4urnA-3lpsA:
27.9		 4urnA-3lpsA:
30.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_B_NOVB2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		11 / 11 ASN A  86
SER A  87
ASP A  89
GLU A  90
ASP A 113
ARG A 116
MET A 118
PRO A 119
ILE A 134
ARG A 176
THR A 207
 NOV  A 901 (-4.0A)
NOV  A 901 (-3.3A)
NOV  A 901 ( 4.8A)
NOV  A 901 (-3.8A)
NOV  A 901 (-3.5A)
NOV  A 901 (-3.4A)
NOV  A 901 (-3.7A)
NOV  A 901 (-4.5A)
NOV  A 901 ( 4.9A)
NOV  A 901 (-2.5A)
NOV  A 901 ( 4.2A)
 0.57A 4urnB-3lpsA:
26.2		 4urnB-3lpsA:
30.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URN_C_NOVC2000_1
(DNA TOPOISOMERASE
IV, B SUBUNIT)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		11 / 11 ASN A  86
SER A  87
ASP A  89
GLU A  90
ASP A 113
ARG A 116
MET A 118
PRO A 119
ILE A 134
ARG A 176
THR A 207
 NOV  A 901 (-4.0A)
NOV  A 901 (-3.3A)
NOV  A 901 ( 4.8A)
NOV  A 901 (-3.8A)
NOV  A 901 (-3.5A)
NOV  A 901 (-3.4A)
NOV  A 901 (-3.7A)
NOV  A 901 (-4.5A)
NOV  A 901 ( 4.9A)
NOV  A 901 (-2.5A)
NOV  A 901 ( 4.2A)
 0.56A 4urnC-3lpsA:
27.9		 4urnC-3lpsA:
30.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		9 / 12 ASN A  86
SER A  87
GLU A  90
ASP A 113
ARG A 116
PRO A 119
ASP A 121
ILE A 134
ARG A 176
 NOV  A 901 (-4.0A)
NOV  A 901 (-3.3A)
NOV  A 901 (-3.8A)
NOV  A 901 (-3.5A)
NOV  A 901 (-3.4A)
NOV  A 901 (-4.5A)
NOV  A 901 (-2.6A)
NOV  A 901 ( 4.9A)
NOV  A 901 (-2.5A)
 0.52A 4uroA-3lpsA:
27.5		 4uroA-3lpsA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		9 / 12 ASN A  86
SER A  87
GLU A  90
ASP A 113
ARG A 116
PRO A 119
ASP A 121
ILE A 134
ARG A 176
 NOV  A 901 (-4.0A)
NOV  A 901 (-3.3A)
NOV  A 901 (-3.8A)
NOV  A 901 (-3.5A)
NOV  A 901 (-3.4A)
NOV  A 901 (-4.5A)
NOV  A 901 (-2.6A)
NOV  A 901 ( 4.9A)
NOV  A 901 (-2.5A)
 0.54A 4uroB-3lpsA:
27.6		 4uroB-3lpsA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		8 / 12 ASN A  86
GLU A  90
ASP A 113
ARG A 116
PRO A 119
ASP A 121
ILE A 134
ARG A 176
 NOV  A 901 (-4.0A)
NOV  A 901 (-3.8A)
NOV  A 901 (-3.5A)
NOV  A 901 (-3.4A)
NOV  A 901 (-4.5A)
NOV  A 901 (-2.6A)
NOV  A 901 ( 4.9A)
NOV  A 901 (-2.5A)
 0.53A 4uroC-3lpsA:
28.0		 4uroC-3lpsA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		5 / 12 ASN A  86
ASP A 113
ARG A 176
ILE A 134
THR A 207
 NOV  A 901 (-4.0A)
NOV  A 901 (-3.5A)
NOV  A 901 (-2.5A)
NOV  A 901 ( 4.9A)
NOV  A 901 ( 4.2A)
 1.35A 4uroD-3lpsA:
27.1		 4uroD-3lpsA:
30.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4URO_D_NOVD2000_1
(DNA GYRASE SUBUNIT B)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		10 / 12 ASN A  86
SER A  87
GLU A  90
ASP A 113
ARG A 116
PRO A 119
ASP A 121
ILE A 134
ARG A 176
THR A 207
 NOV  A 901 (-4.0A)
NOV  A 901 (-3.3A)
NOV  A 901 (-3.8A)
NOV  A 901 (-3.5A)
NOV  A 901 (-3.4A)
NOV  A 901 (-4.5A)
NOV  A 901 (-2.6A)
NOV  A 901 ( 4.9A)
NOV  A 901 (-2.5A)
NOV  A 901 ( 4.2A)
 0.49A 4uroD-3lpsA:
27.1		 4uroD-3lpsA:
30.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		3 / 3 TRP A 257
ARG A 229
LEU A 231
 None
 0.86A 5dbyA-3lpsA:
undetectable		 5dbyA-3lpsA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		5 / 12 LEU A 267
PHE A 361
SER A 309
VAL A 362
ALA A 234
 None
 1.17A 5tzoB-3lpsA:
undetectable		 5tzoB-3lpsA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		3 / 3 GLY A 130
LEU A 133
HIS A 123
 None
 0.50A 5u63A-3lpsA:
undetectable		 5u63A-3lpsA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		3 / 3 GLY A 130
LEU A 133
HIS A 123
 None
 0.53A 5u63B-3lpsA:
undetectable		 5u63B-3lpsA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		5 / 10 LEU A 246
LEU A 228
GLU A 110
VAL A 111
ILE A  84
 None
 1.06A 5v02B-3lpsA:
undetectable
5v02R-3lpsA:
undetectable		 5v02B-3lpsA:
12.37
5v02R-3lpsA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 3lps TOPOISOMERASE IV
SUBUNIT B
(Xanthomonas
oryzae) 		4 / 8 VAL A 163
THR A  71
ASP A  85
VAL A 158
 None
 1.00A 6cp4A-3lpsA:
undetectable		 6cp4A-3lpsA:
21.66