SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lpx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 3lpx DNA GYRASE, A
SUBUNIT
(Colwellia
psychrerythraea) 		4 / 6 ILE A 130
SER A 133
ARG A 162
ILE A 191
 None
 1.15A 2q72A-3lpxA:
undetectable		 2q72A-3lpxA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_C_VDYC6178_1
(VITAMIN D
HYDROXYLASE)		 3lpx DNA GYRASE, A
SUBUNIT
(Colwellia
psychrerythraea) 		5 / 12 THR A 324
MET A 277
ILE A 274
LEU A 273
ILE A 305
 None
 0.99A 3a51C-3lpxA:
1.7		 3a51C-3lpxA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 3lpx DNA GYRASE, A
SUBUNIT
(Colwellia
psychrerythraea) 		4 / 6 ARG A 517
PHE A 217
TYR A 266
PRO A 215
 None
 1.33A 3jqaA-3lpxA:
undetectable		 3jqaA-3lpxA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 3lpx DNA GYRASE, A
SUBUNIT
(Colwellia
psychrerythraea) 		4 / 6 ARG A 517
PHE A 217
TYR A 266
PRO A 215
 None
 1.26A 3jqaC-3lpxA:
undetectable		 3jqaC-3lpxA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3lpx DNA GYRASE, A
SUBUNIT
(Colwellia
psychrerythraea) 		3 / 3 ASN A 399
ASN A 401
GLU A 405
 None
 0.93A 3kpdB-3lpxA:
undetectable		 3kpdB-3lpxA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3lpx DNA GYRASE, A
SUBUNIT
(Colwellia
psychrerythraea) 		3 / 3 ARG A 358
GLU A 360
THR A 142
 None
 0.90A 3v4tA-3lpxA:
undetectable		 3v4tA-3lpxA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3lpx DNA GYRASE, A
SUBUNIT
(Colwellia
psychrerythraea) 		5 / 12 ILE A 274
LEU A 286
LEU A 292
VAL A 316
LEU A 273
 None
 1.20A 4m11C-3lpxA:
1.4		 4m11C-3lpxA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3lpx DNA GYRASE, A
SUBUNIT
(Colwellia
psychrerythraea) 		5 / 12 ILE A 182
PRO A 215
LEU A 332
ARG A  99
GLY A 170
 None
 1.33A 5k7uA-3lpxA:
undetectable		 5k7uA-3lpxA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 3lpx DNA GYRASE, A
SUBUNIT
(Colwellia
psychrerythraea) 		5 / 12 LEU A 203
LEU A 351
ILE A 502
LEU A 506
LEU A 356
 None
 1.26A 5toaB-3lpxA:
undetectable		 5toaB-3lpxA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3lpx DNA GYRASE, A
SUBUNIT
(Colwellia
psychrerythraea) 		4 / 7 THR A 519
PHE A 217
HIS A 185
ILE A 212
 None
 1.20A 5vkqA-3lpxA:
3.4
5vkqB-3lpxA:
3.4		 5vkqA-3lpxA:
15.38
5vkqB-3lpxA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3lpx DNA GYRASE, A
SUBUNIT
(Colwellia
psychrerythraea) 		4 / 7 THR A 519
PHE A 217
HIS A 185
ILE A 212
 None
 1.18A 5vkqC-3lpxA:
3.3
5vkqD-3lpxA:
3.4		 5vkqC-3lpxA:
15.38
5vkqD-3lpxA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 3lpx DNA GYRASE, A
SUBUNIT
(Colwellia
psychrerythraea) 		5 / 11 THR A  88
VAL A 103
MET A  92
ILE A  74
VAL A  73
 None
 1.45A 6hcoA-3lpxA:
undetectable
6hcoB-3lpxA:
undetectable		 6hcoA-3lpxA:
21.25
6hcoB-3lpxA:
21.25