SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lpz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 3lpz GET4 (YOR164C
HOMOLOG)
(Chaetomium
thermophilum) 		3 / 3 MET A 243
LEU A 246
SER A 247
 None
 0.38A 1ee2A-3lpzA:
undetectable		 1ee2A-3lpzA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 3lpz GET4 (YOR164C
HOMOLOG)
(Chaetomium
thermophilum) 		3 / 3 ALA A  88
VAL A  85
TRP A 117
 None
 0.90A 1micA-3lpzA:
undetectable
1micB-3lpzA:
undetectable		 1micA-3lpzA:
4.26
1micB-3lpzA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 3lpz GET4 (YOR164C
HOMOLOG)
(Chaetomium
thermophilum) 		3 / 3 ARG A  32
VAL A  48
THR A  77
 None
 0.85A 3nduD-3lpzA:
undetectable		 3nduD-3lpzA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3lpz GET4 (YOR164C
HOMOLOG)
(Chaetomium
thermophilum) 		5 / 12 ILE A   8
ILE A   9
LEU A  12
ALA A  47
VAL A  54
 None
 0.69A 3rukB-3lpzA:
undetectable		 3rukB-3lpzA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1000_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3lpz GET4 (YOR164C
HOMOLOG)
(Chaetomium
thermophilum) 		4 / 6 GLU A 149
LYS A 150
TRP A 170
GLU A 144
 None
 1.22A 4a7tA-3lpzA:
undetectable		 4a7tA-3lpzA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3lpz GET4 (YOR164C
HOMOLOG)
(Chaetomium
thermophilum) 		4 / 6 GLU A 149
LYS A 150
TRP A 170
GLU A 144
 None
 1.20A 4a7uA-3lpzA:
undetectable		 4a7uA-3lpzA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 3lpz GET4 (YOR164C
HOMOLOG)
(Chaetomium
thermophilum) 		3 / 3 ARG A 230
GLU A 228
ASN A 221
 None
 0.82A 4imaD-3lpzA:
undetectable		 4imaD-3lpzA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 3lpz GET4 (YOR164C
HOMOLOG)
(Chaetomium
thermophilum) 		3 / 3 ARG A 230
GLU A 228
ASN A 221
 None
 0.82A 4ip7D-3lpzA:
undetectable		 4ip7D-3lpzA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA603_1
(SERUM ALBUMIN)		 3lpz GET4 (YOR164C
HOMOLOG)
(Chaetomium
thermophilum) 		5 / 11 LEU A  70
ARG A  32
SER A  66
LEU A  51
LEU A  58
 None
 1.42A 4or0A-3lpzA:
3.3		 4or0A-3lpzA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_C_QDNC602_1
(CYTOCHROME P450 2D6)		 3lpz GET4 (YOR164C
HOMOLOG)
(Chaetomium
thermophilum) 		5 / 11 GLY A  62
LEU A  59
GLU A 104
ALA A  28
PHE A 100
 None
 1.20A 4wnuC-3lpzA:
undetectable		 4wnuC-3lpzA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 3lpz GET4 (YOR164C
HOMOLOG)
(Chaetomium
thermophilum) 		5 / 9 LEU A  70
GLY A  67
ILE A  50
LEU A  12
THR A  31
 None
 1.11A 4x3mB-3lpzA:
undetectable		 4x3mB-3lpzA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 3lpz GET4 (YOR164C
HOMOLOG)
(Chaetomium
thermophilum) 		5 / 12 LEU A 163
ASP A 174
THR A 178
LEU A 181
ILE A 281
 None
 1.49A 5dlvA-3lpzA:
undetectable		 5dlvA-3lpzA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 3lpz GET4 (YOR164C
HOMOLOG)
(Chaetomium
thermophilum) 		5 / 12 LEU A 163
ASP A 174
THR A 178
LEU A 181
ILE A 281
 None
 1.50A 5dlvB-3lpzA:
undetectable		 5dlvB-3lpzA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3lpz GET4 (YOR164C
HOMOLOG)
(Chaetomium
thermophilum) 		4 / 6 VAL A 106
LEU A  74
ARG A  79
PHE A  78
 None
 0.88A 5jw1A-3lpzA:
undetectable		 5jw1A-3lpzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3lpz GET4 (YOR164C
HOMOLOG)
(Chaetomium
thermophilum) 		6 / 12 GLY A  64
GLY A  62
VAL A  54
LEU A  70
GLY A  67
GLY A  68
 None
 1.44A 5zhmB-3lpzA:
undetectable		 5zhmB-3lpzA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3lpz GET4 (YOR164C
HOMOLOG)
(Chaetomium
thermophilum) 		5 / 10 VAL A 187
ALA A 186
LEU A 238
LEU A 229
LEU A 245
 None
 1.01A 6f6nA-3lpzA:
undetectable
6f6nB-3lpzA:
undetectable		 6f6nA-3lpzA:
13.79
6f6nB-3lpzA:
12.96