SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lqz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3lqz HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DP ALPHA 1
CHAIN
(Homo
sapiens) 		4 / 5 THR A  41
PHE A  54
GLU A  55
GLY A  58
 None
 1.29A 1icvC-3lqzA:
undetectable
1icvD-3lqzA:
undetectable		 1icvC-3lqzA:
23.04
1icvD-3lqzA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3lqz HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DP ALPHA 1
CHAIN
(Homo
sapiens) 		4 / 5 GLU A  55
GLY A  58
THR A  41
PHE A  54
 None
 1.27A 1icvC-3lqzA:
undetectable
1icvD-3lqzA:
undetectable		 1icvC-3lqzA:
23.04
1icvD-3lqzA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3lqz HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DP ALPHA 1
CHAIN
(Homo
sapiens) 		4 / 8 PHE A 145
PHE A 113
GLN A  14
TRP A 168
 None
None
None
NAG  A 182 ( 4.0A)
 1.07A 2aoxA-3lqzA:
undetectable		 2aoxA-3lqzA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_B_THAB401_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3lqz HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DP ALPHA 1
CHAIN
(Homo
sapiens) 		4 / 7 PHE A 145
PHE A 113
GLN A  14
TRP A 168
 None
None
None
NAG  A 182 ( 4.0A)
 1.07A 2aoxB-3lqzA:
undetectable		 2aoxB-3lqzA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3lqz HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DP ALPHA 1
CHAIN
(Homo
sapiens) 		3 / 3 SER A 144
GLU A  88
ASP A  85
 None
 0.84A 3bwmA-3lqzA:
undetectable		 3bwmA-3lqzA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 3lqz HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DP ALPHA 1
CHAIN
(Homo
sapiens) 		3 / 3 SER A 144
GLU A  88
ASP A  85
 None
 0.84A 3bwyA-3lqzA:
undetectable		 3bwyA-3lqzA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3lqz HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DP ALPHA 1
CHAIN
(Homo
sapiens) 		4 / 6 GLU A  21
HIS A 108
VAL A 165
PHE A 137
 None
 1.22A 4a97E-3lqzA:
3.6		 4a97E-3lqzA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM7_A_29JA603_1
(TRANSPORTER)		 3lqz HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DP ALPHA 1
CHAIN
(Homo
sapiens) 		5 / 10 VAL A  42
TYR A  33
SER A  53
GLY A  49
ASP A  35
 None
 1.46A 4mm7A-3lqzA:
undetectable		 4mm7A-3lqzA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3lqz HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DP ALPHA 1
CHAIN
(Homo
sapiens) 		4 / 7 ILE A  63
LEU A  60
GLY A  58
GLY A  59
 None
 0.83A 5a06A-3lqzA:
undetectable		 5a06A-3lqzA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3lqz HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DP ALPHA 1
CHAIN
(Homo
sapiens) 		4 / 7 ILE A  63
LEU A  60
GLY A  58
GLY A  59
 None
 0.81A 5a06B-3lqzA:
undetectable		 5a06B-3lqzA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3lqz HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DP ALPHA 1
CHAIN
(Homo
sapiens) 		4 / 7 ILE A  63
LEU A  60
GLY A  58
GLY A  59
 None
 0.81A 5a06C-3lqzA:
undetectable		 5a06C-3lqzA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3lqz HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DP ALPHA 1
CHAIN
(Homo
sapiens) 		4 / 7 ILE A  63
LEU A  60
GLY A  58
GLY A  59
 None
 0.83A 5a06E-3lqzA:
undetectable		 5a06E-3lqzA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3lqz HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DP ALPHA 1
CHAIN
(Homo
sapiens) 		4 / 7 ILE A  63
LEU A  60
GLY A  58
GLY A  59
 None
 0.81A 5a06F-3lqzA:
undetectable		 5a06F-3lqzA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 3lqz HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DP ALPHA 1
CHAIN
(Homo
sapiens) 		4 / 4 LEU A 170
ASP A 171
GLN A 172
VAL A 132
 None
 1.44A 6bzoF-3lqzA:
undetectable		 6bzoF-3lqzA:
16.44