SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lra'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 3lra DISKS LARGE HOMOLOG
1, MAGUK P55
SUBFAMILY MEMBER 7,
PROTEIN LIN-7
HOMOLOG C
(Homo
sapiens) 		5 / 9 ASN A 154
LEU A 148
ALA A 145
LEU A 144
LEU A 164
 None
 0.98A 1hwiA-3lraA:
undetectable		 1hwiA-3lraA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 3lra DISKS LARGE HOMOLOG
1, MAGUK P55
SUBFAMILY MEMBER 7,
PROTEIN LIN-7
HOMOLOG C
(Homo
sapiens) 		4 / 8 ASN A 154
LEU A 148
ALA A 145
LEU A 144
 None
 0.84A 1hwiD-3lraA:
undetectable		 1hwiD-3lraA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_D_C2FD1200_0
(GLYCINE
N-METHYLTRANSFERASE)		 3lra DISKS LARGE HOMOLOG
1, MAGUK P55
SUBFAMILY MEMBER 7,
PROTEIN LIN-7
HOMOLOG C
(Homo
sapiens) 		5 / 12 LEU A 103
SER A  20
TYR A  18
LEU A  14
HIS A  13
 None
 1.13A 3thrA-3lraA:
undetectable
3thrB-3lraA:
undetectable
3thrC-3lraA:
undetectable
3thrD-3lraA:
undetectable		 3thrA-3lraA:
22.26
3thrB-3lraA:
22.26
3thrC-3lraA:
22.26
3thrD-3lraA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3lra DISKS LARGE HOMOLOG
1, MAGUK P55
SUBFAMILY MEMBER 7,
PROTEIN LIN-7
HOMOLOG C
(Homo
sapiens) 		5 / 11 LEU A 160
LEU A 164
GLU A 213
ALA A 228
LEU A 229
 None
 1.11A 4wg0H-3lraA:
undetectable
4wg0I-3lraA:
undetectable
4wg0J-3lraA:
undetectable		 4wg0H-3lraA:
4.35
4wg0I-3lraA:
4.35
4wg0J-3lraA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3lra DISKS LARGE HOMOLOG
1, MAGUK P55
SUBFAMILY MEMBER 7,
PROTEIN LIN-7
HOMOLOG C
(Homo
sapiens) 		5 / 11 LEU A 212
GLU A 156
LEU A 160
LEU A 148
LEU A 144
 None
 1.03A 4wg0K-3lraA:
undetectable
4wg0L-3lraA:
undetectable
4wg0M-3lraA:
undetectable		 4wg0K-3lraA:
4.35
4wg0L-3lraA:
4.35
4wg0M-3lraA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 3lra DISKS LARGE HOMOLOG
1, MAGUK P55
SUBFAMILY MEMBER 7,
PROTEIN LIN-7
HOMOLOG C
(Homo
sapiens) 		4 / 7 VAL A   3
GLN A  53
LEU A 115
SER A 114
 None
 1.09A 4zphA-3lraA:
undetectable
4zphB-3lraA:
undetectable		 4zphA-3lraA:
20.15
4zphB-3lraA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3lra DISKS LARGE HOMOLOG
1, MAGUK P55
SUBFAMILY MEMBER 7,
PROTEIN LIN-7
HOMOLOG C
(Homo
sapiens) 		4 / 4 GLN A   9
THR A   8
GLU A  54
LEU A 189
 None
 1.06A 5m66A-3lraA:
undetectable		 5m66A-3lraA:
19.28