SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lre'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3lre KINESIN-LIKE PROTEIN
KIF18A
(Homo
sapiens) 		5 / 12 LEU A 259
LEU A 312
GLY A 289
SER A 310
ALA A 352
 None
 1.14A 2br4A-3lreA:
undetectable		 2br4A-3lreA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 3lre KINESIN-LIKE PROTEIN
KIF18A
(Homo
sapiens) 		5 / 12 VAL A 187
LEU A 160
THR A 108
ILE A 257
LEU A 312
 None
 1.14A 2oipA-3lreA:
undetectable		 2oipA-3lreA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3lre KINESIN-LIKE PROTEIN
KIF18A
(Homo
sapiens) 		5 / 12 LEU A 160
VAL A 189
HIS A 229
LEU A 285
LEU A 110
 None
 1.48A 2prgB-3lreA:
undetectable		 2prgB-3lreA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 3lre KINESIN-LIKE PROTEIN
KIF18A
(Homo
sapiens) 		3 / 3 LYS A 311
ARG A 168
VAL A 162
 None
 0.99A 2r2vC-3lreA:
undetectable
2r2vD-3lreA:
undetectable		 2r2vC-3lreA:
9.85
2r2vD-3lreA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 3lre KINESIN-LIKE PROTEIN
KIF18A
(Homo
sapiens) 		5 / 12 ALA A 349
VAL A  36
THR A  93
VAL A 109
MET A 328
 None
 1.06A 3czhA-3lreA:
undetectable		 3czhA-3lreA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 3lre KINESIN-LIKE PROTEIN
KIF18A
(Homo
sapiens) 		5 / 12 ALA A 349
VAL A  36
THR A  93
VAL A 109
MET A 328
 None
 1.04A 3czhB-3lreA:
undetectable		 3czhB-3lreA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3lre KINESIN-LIKE PROTEIN
KIF18A
(Homo
sapiens) 		4 / 4 PHE A 232
TYR A 134
ILE A 327
LEU A 110
 None
 1.32A 3sudA-3lreA:
undetectable		 3sudA-3lreA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 3lre KINESIN-LIKE PROTEIN
KIF18A
(Homo
sapiens) 		5 / 12 MET A 123
LEU A 135
ILE A 329
ILE A 327
LEU A 256
 None
 1.16A 4j24A-3lreA:
undetectable		 4j24A-3lreA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 3lre KINESIN-LIKE PROTEIN
KIF18A
(Homo
sapiens) 		5 / 12 MET A 123
LEU A 135
ILE A 329
ILE A 327
LEU A 256
 None
 1.16A 4j24C-3lreA:
undetectable		 4j24C-3lreA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 3lre KINESIN-LIKE PROTEIN
KIF18A
(Homo
sapiens) 		5 / 12 ALA A 117
TYR A 348
TYR A 112
LEU A 285
LEU A 288
 ADP  A 500 (-4.4A)
None
None
None
None
 1.14A 4l9qB-3lreA:
undetectable		 4l9qB-3lreA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 3lre KINESIN-LIKE PROTEIN
KIF18A
(Homo
sapiens) 		5 / 12 LYS A 347
TYR A 348
TYR A 112
LEU A 285
LEU A 288
 None
 1.24A 4l9qB-3lreA:
undetectable		 4l9qB-3lreA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3lre KINESIN-LIKE PROTEIN
KIF18A
(Homo
sapiens) 		5 / 11 LEU A 312
LEU A 288
LEU A 316
ALA A 111
LEU A 110
 None
 1.20A 4wg0D-3lreA:
undetectable
4wg0E-3lreA:
undetectable
4wg0F-3lreA:
undetectable		 4wg0D-3lreA:
3.38
4wg0E-3lreA:
3.38
4wg0F-3lreA:
3.38