SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lrh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 VAL A 109
ARG A  62
VAL A  18
GLU A  84
 None
 0.93A 1zzrA-3lrhA:
undetectable
1zzrB-3lrhA:
undetectable		 1zzrA-3lrhA:
17.01
1zzrB-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 GLU A  84
VAL A 109
ARG A  62
VAL A  18
 None
 0.95A 1zzrA-3lrhA:
undetectable
1zzrB-3lrhA:
undetectable		 1zzrA-3lrhA:
17.01
1zzrB-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 VAL A 109
ARG A  62
VAL A  18
GLU A  84
 None
 0.91A 1zzuA-3lrhA:
undetectable
1zzuB-3lrhA:
undetectable		 1zzuA-3lrhA:
17.01
1zzuB-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 GLU A  84
VAL A 109
ARG A  62
VAL A  18
 None
 0.91A 1zzuA-3lrhA:
undetectable
1zzuB-3lrhA:
undetectable		 1zzuA-3lrhA:
17.01
1zzuB-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		3 / 3 TRP A  36
GLN A  38
TRP A  99
 None
 1.36A 2vqyA-3lrhA:
undetectable		 2vqyA-3lrhA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 8 LEU A  40
VAL A 109
ILE A  76
PHE A  63
 None
 0.97A 2weyB-3lrhA:
undetectable		 2weyB-3lrhA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 VAL A 109
ARG A  62
VAL A  18
GLU A  84
 None
 0.94A 3dqrA-3lrhA:
undetectable
3dqrB-3lrhA:
undetectable		 3dqrA-3lrhA:
17.01
3dqrB-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DQR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 GLU A  84
VAL A 109
ARG A  62
VAL A  18
 None
 0.96A 3dqrA-3lrhA:
undetectable
3dqrB-3lrhA:
undetectable		 3dqrA-3lrhA:
17.01
3dqrB-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 VAL A 109
ARG A  62
VAL A  18
GLU A  84
 None
 0.90A 3jx2A-3lrhA:
undetectable
3jx2B-3lrhA:
undetectable		 3jx2A-3lrhA:
17.01
3jx2B-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 GLU A  84
VAL A 109
ARG A  62
VAL A  18
 None
 0.91A 3jx2A-3lrhA:
undetectable
3jx2B-3lrhA:
undetectable		 3jx2A-3lrhA:
17.01
3jx2B-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 VAL A 109
ARG A  62
VAL A  18
GLU A  84
 None
 0.95A 3jx3A-3lrhA:
undetectable
3jx3B-3lrhA:
undetectable		 3jx3A-3lrhA:
17.01
3jx3B-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 GLU A  84
VAL A 109
ARG A  62
VAL A  18
 None
 0.91A 3jx3A-3lrhA:
undetectable
3jx3B-3lrhA:
undetectable		 3jx3A-3lrhA:
17.01
3jx3B-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 GLU A  84
VAL A 109
ARG A  62
VAL A  18
 None
 0.94A 3jx4A-3lrhA:
undetectable
3jx4B-3lrhA:
undetectable		 3jx4A-3lrhA:
17.01
3jx4B-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 VAL A 109
ARG A  62
VAL A  18
GLU A  84
 None
 0.92A 3jx5A-3lrhA:
undetectable
3jx5B-3lrhA:
undetectable		 3jx5A-3lrhA:
17.01
3jx5B-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 GLU A  84
VAL A 109
ARG A  62
VAL A  18
 None
 0.92A 3jx5A-3lrhA:
undetectable
3jx5B-3lrhA:
undetectable		 3jx5A-3lrhA:
17.01
3jx5B-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 VAL A 109
ARG A  62
VAL A  18
GLU A  84
 None
 0.83A 3jx6A-3lrhA:
undetectable
3jx6B-3lrhA:
undetectable		 3jx6A-3lrhA:
17.27
3jx6B-3lrhA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX6_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 GLU A  84
VAL A 109
ARG A  62
VAL A  18
 None
 0.87A 3jx6A-3lrhA:
undetectable
3jx6B-3lrhA:
undetectable		 3jx6A-3lrhA:
17.27
3jx6B-3lrhA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 VAL A 109
ARG A  62
VAL A  18
GLU A  84
 None
 0.86A 3nljA-3lrhA:
undetectable
3nljB-3lrhA:
undetectable		 3nljA-3lrhA:
17.27
3nljB-3lrhA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLJ_B_H4BB761_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 GLU A  84
VAL A 109
ARG A  62
VAL A  18
 None
 0.88A 3nljA-3lrhA:
undetectable
3nljB-3lrhA:
undetectable		 3nljA-3lrhA:
17.27
3nljB-3lrhA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 VAL A 109
ARG A  62
VAL A  18
GLU A  84
 None
 0.90A 3nlpA-3lrhA:
undetectable
3nlpB-3lrhA:
undetectable		 3nlpA-3lrhA:
17.01
3nlpB-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 GLU A  84
VAL A 109
ARG A  62
VAL A  18
 None
 0.93A 3nlpA-3lrhA:
undetectable
3nlpB-3lrhA:
undetectable		 3nlpA-3lrhA:
17.01
3nlpB-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 8 VAL A 109
ARG A  62
VAL A  18
GLU A  84
 None
 0.88A 3nlqA-3lrhA:
undetectable
3nlqB-3lrhA:
undetectable		 3nlqA-3lrhA:
17.01
3nlqB-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 GLU A  84
VAL A 109
ARG A  62
VAL A  18
 None
 0.89A 3nlqA-3lrhA:
undetectable
3nlqB-3lrhA:
undetectable		 3nlqA-3lrhA:
17.01
3nlqB-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 VAL A 109
ARG A  62
VAL A  18
GLU A  84
 None
 0.89A 3nlrA-3lrhA:
undetectable
3nlrB-3lrhA:
undetectable		 3nlrA-3lrhA:
17.01
3nlrB-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 8 GLU A  84
VAL A 109
ARG A  62
VAL A  18
 None
 0.90A 3nlrA-3lrhA:
undetectable
3nlrB-3lrhA:
undetectable		 3nlrA-3lrhA:
17.01
3nlrB-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_A_HCYA1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		5 / 12 ALA A  12
SER A  11
VAL A 107
ILE A  20
SER A  73
 None
 1.25A 4c49A-3lrhA:
undetectable		 4c49A-3lrhA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 VAL A 109
ARG A  62
VAL A  18
GLU A  84
 None
 0.92A 4cx3A-3lrhA:
undetectable
4cx3B-3lrhA:
undetectable		 4cx3A-3lrhA:
17.01
4cx3B-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 GLU A  84
VAL A 109
ARG A  62
VAL A  18
 None
 0.92A 4cx3A-3lrhA:
undetectable
4cx3B-3lrhA:
undetectable		 4cx3A-3lrhA:
17.01
4cx3B-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 VAL A 109
ARG A  62
VAL A  18
GLU A  84
 None
 0.94A 4cx4A-3lrhA:
undetectable
4cx4B-3lrhA:
undetectable		 4cx4A-3lrhA:
17.01
4cx4B-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 GLU A  84
VAL A 109
ARG A  62
VAL A  18
 None
 0.92A 4cx4A-3lrhA:
undetectable
4cx4B-3lrhA:
undetectable		 4cx4A-3lrhA:
17.01
4cx4B-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		5 / 12 GLY A 102
GLY A 104
SER A   7
ILE A  37
ALA A  89
 None
 1.09A 4qtuB-3lrhA:
undetectable		 4qtuB-3lrhA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		5 / 12 GLY A 102
GLY A 104
SER A   7
ILE A  37
ALA A  89
 None
 1.11A 4qtuD-3lrhA:
undetectable		 4qtuD-3lrhA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 5 VAL A  18
ILE A  20
VAL A 107
THR A 105
 None
 0.76A 4xdtA-3lrhA:
undetectable		 4xdtA-3lrhA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 GLU A  84
VAL A 109
ARG A  62
VAL A  18
 None
 0.88A 5addA-3lrhA:
undetectable
5addB-3lrhA:
undetectable		 5addA-3lrhA:
17.01
5addB-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 GLU A  84
VAL A 109
ARG A  62
VAL A  18
 None
 0.87A 5adeA-3lrhA:
undetectable
5adeB-3lrhA:
undetectable		 5adeA-3lrhA:
17.01
5adeB-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 VAL A 109
ARG A  62
VAL A  18
GLU A  84
 None
 0.91A 5g0pA-3lrhA:
undetectable
5g0pB-3lrhA:
undetectable		 5g0pA-3lrhA:
17.01
5g0pB-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 7 GLU A  84
VAL A 109
ARG A  62
VAL A  18
 None
 0.92A 5g0pA-3lrhA:
undetectable
5g0pB-3lrhA:
undetectable		 5g0pA-3lrhA:
17.01
5g0pB-3lrhA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens) 		4 / 8 THR A  19
SER A  64
ALA A  72
ASP A  52
 None
 1.09A 5l5fY-3lrhA:
undetectable
5l5fZ-3lrhA:
undetectable		 5l5fY-3lrhA:
20.74
5l5fZ-3lrhA:
19.82