SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lrk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		4 / 4 THR A 272
LEU A 271
VAL A 266
LEU A 264
 None
 0.95A 1fbmD-3lrkA:
undetectable		 1fbmD-3lrkA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 310
VAL A 312
TRP A 397
 GOL  A7003 (-3.6A)
None
None
 0.87A 1nt6A-3lrkA:
undetectable		 1nt6A-3lrkA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		3 / 3 ALA A 310
VAL A 312
TRP A 397
 GOL  A7003 (-3.6A)
None
None
 0.88A 1nt6B-3lrkA:
undetectable		 1nt6B-3lrkA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 360
ALA A 358
ALA A 284
VAL A 286
ALA A 324
 None
 1.12A 1sa1A-3lrkA:
undetectable
1sa1B-3lrkA:
undetectable		 1sa1A-3lrkA:
20.97
1sa1B-3lrkA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 360
ALA A 358
ALA A 284
VAL A 286
ALA A 324
 None
 1.12A 1sa1C-3lrkA:
undetectable
1sa1D-3lrkA:
undetectable		 1sa1C-3lrkA:
20.97
1sa1D-3lrkA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 439
ASP A 436
GLY A 418
ALA A 310
 None
None
None
GOL  A7003 (-3.6A)
 0.89A 2aohA-3lrkA:
undetectable		 2aohA-3lrkA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ECP_B_ACRB992_1
(MALTODEXTRIN
PHOSPHORYLASE)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		5 / 10 ASN A 150
ASP A 262
ARG A 205
ASP A  73
ALA A 233
 None
GOL  A7002 (-2.9A)
GOL  A7002 (-3.9A)
GOL  A7001 (-3.4A)
None
 1.32A 2ecpB-3lrkA:
undetectable		 2ecpB-3lrkA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 307
GLU A 276
ASN A 270
 None
None
NAG  A3001 (-2.2A)
 0.75A 2y7hC-3lrkA:
undetectable		 2y7hC-3lrkA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  69
LEU A 103
PHE A 108
ARG A  55
 None
 1.03A 2zxwN-3lrkA:
undetectable
2zxwW-3lrkA:
undetectable		 2zxwN-3lrkA:
20.99
2zxwW-3lrkA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  69
LEU A 103
PHE A 108
ARG A  55
 None
 0.98A 3ag2N-3lrkA:
undetectable
3ag2W-3lrkA:
undetectable		 3ag2N-3lrkA:
20.99
3ag2W-3lrkA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A  69
LEU A 103
PHE A 108
ARG A  55
 None
 1.01A 3ag4N-3lrkA:
undetectable
3ag4W-3lrkA:
undetectable		 3ag4N-3lrkA:
20.99
3ag4W-3lrkA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 340
GLU A 213
THR A 211
HIS A 236
 None
 1.47A 3glqB-3lrkA:
undetectable		 3glqB-3lrkA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		3 / 3 SER A  45
ASP A  43
ASP A  51
 None
 0.87A 3iv6A-3lrkA:
undetectable		 3iv6A-3lrkA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 201
ILE A 200
GLY A 199
SER A 184
LEU A 185
 None
 1.08A 3kw2A-3lrkA:
undetectable		 3kw2A-3lrkA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		5 / 11 ALA A 201
ILE A 200
GLY A 199
SER A 184
LEU A 185
 None
 1.11A 3kw2B-3lrkA:
undetectable		 3kw2B-3lrkA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 331
GLY A 362
GLY A 341
ALA A 278
LEU A 360
 None
 1.19A 3vywA-3lrkA:
undetectable		 3vywA-3lrkA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_B_SAMB401_0
(MNMC2)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 331
GLY A 362
GLY A 341
ALA A 278
LEU A 360
 None
 1.17A 3vywB-3lrkA:
undetectable		 3vywB-3lrkA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_0
(MNMC2)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 331
GLY A 362
GLY A 341
ALA A 278
LEU A 360
 None
 1.20A 3vywD-3lrkA:
undetectable		 3vywD-3lrkA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 274
ARG A 400
LYS A 277
 None
 1.15A 3wipG-3lrkA:
undetectable		 3wipG-3lrkA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_D_HCYD1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		5 / 12 SER A 347
GLN A 309
ILE A 315
SER A 311
PHE A 464
 None
GOL  A7003 (-4.1A)
None
None
None
 1.44A 4c49D-3lrkA:
undetectable		 4c49D-3lrkA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 149
ASN A 153
SER A 207
 GOL  A7001 (-4.1A)
None
None
 0.71A 4obwA-3lrkA:
undetectable		 4obwA-3lrkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		3 / 3 ASN A  38
ASP A  35
ASP A 149
 GOL  A7002 (-4.0A)
GOL  A7002 (-3.5A)
GOL  A7001 (-4.1A)
 0.88A 4obwD-3lrkA:
undetectable		 4obwD-3lrkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 149
TYR A 113
TRP A 188
 GOL  A7001 (-4.1A)
GOL  A7001 ( 4.9A)
None
 1.00A 4p7nA-3lrkA:
9.8		 4p7nA-3lrkA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		4 / 6 ILE A  69
LEU A 103
PHE A 108
ARG A  55
 None
 0.96A 5b1aN-3lrkA:
undetectable
5b1aW-3lrkA:
undetectable		 5b1aN-3lrkA:
20.99
5b1aW-3lrkA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  50
GLY A  33
ALA A  53
LEU A 103
GLY A 293
 None
 0.77A 5kb5A-3lrkA:
undetectable		 5kb5A-3lrkA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB306_0
(WELO5)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 342
ARG A 329
TYR A 331
 None
 0.47A 5trqB-3lrkA:
undetectable		 5trqB-3lrkA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		4 / 7 THR A 177
PHE A 138
LEU A 146
SER A 115
 None
 1.19A 5uxcA-3lrkA:
2.2		 5uxcA-3lrkA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		4 / 5 ASN A  36
ASP A  35
ASN A 263
ASP A 209
 None
GOL  A7002 (-3.5A)
GOL  A7002 (-3.1A)
GOL  A7002 ( 3.9A)
 1.02A 5vooA-3lrkA:
8.5		 5vooA-3lrkA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		4 / 5 ASN A  36
ASP A  35
ASN A 263
ASP A 209
 None
GOL  A7002 (-3.5A)
GOL  A7002 (-3.1A)
GOL  A7002 ( 3.9A)
 1.03A 5vooC-3lrkA:
8.5		 5vooC-3lrkA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		4 / 5 ASN A  36
ASP A  35
ASN A 263
ASP A 209
 None
GOL  A7002 (-3.5A)
GOL  A7002 (-3.1A)
GOL  A7002 ( 3.9A)
 1.04A 5vooE-3lrkA:
8.4		 5vooE-3lrkA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		4 / 8 ILE A  69
LEU A 103
PHE A 108
ARG A  55
 None
 0.94A 5zcqN-3lrkA:
undetectable
5zcqW-3lrkA:
undetectable		 5zcqN-3lrkA:
20.99
5zcqW-3lrkA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 260
ILE A 291
ASN A  36
TYR A 113
 None
None
None
GOL  A7001 ( 4.9A)
 1.09A 6hisA-3lrkA:
undetectable
6hisB-3lrkA:
undetectable		 6hisA-3lrkA:
12.44
6hisB-3lrkA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 260
ILE A 291
ASN A  36
TYR A 113
 None
None
None
GOL  A7001 ( 4.9A)
 1.10A 6hisB-3lrkA:
undetectable
6hisC-3lrkA:
undetectable		 6hisB-3lrkA:
12.44
6hisC-3lrkA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 260
ILE A 291
ASN A  36
TYR A 113
 None
None
None
GOL  A7001 ( 4.9A)
 1.09A 6hisC-3lrkA:
undetectable
6hisD-3lrkA:
undetectable		 6hisC-3lrkA:
12.44
6hisD-3lrkA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 260
ILE A 291
ASN A  36
TYR A 113
 None
None
None
GOL  A7001 ( 4.9A)
 1.09A 6hisD-3lrkA:
undetectable
6hisE-3lrkA:
undetectable		 6hisD-3lrkA:
12.44
6hisE-3lrkA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 3lrk ALPHA-GALACTOSIDASE
1
(Saccharomyces
cerevisiae) 		4 / 8 ASN A  36
TYR A 113
ASP A 260
ILE A 291
 None
GOL  A7001 ( 4.9A)
None
None
 1.09A 6hisA-3lrkA:
undetectable
6hisE-3lrkA:
undetectable		 6hisA-3lrkA:
12.44
6hisE-3lrkA:
12.44