SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lrp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 3lrp ADP-RIBOSYLATION
FACTOR 1
(Plasmodium
falciparum) 		4 / 7 ALA A 103
GLU A 106
LEU A 107
VAL A 123
 None
 0.93A 1hk2A-3lrpA:
undetectable		 1hk2A-3lrpA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 3lrp ADP-RIBOSYLATION
FACTOR 1
(Plasmodium
falciparum) 		5 / 10 LEU A 166
LEU A  34
VAL A  37
ILE A  20
PHE A 170
 None
 1.16A 2w9gA-3lrpA:
undetectable		 2w9gA-3lrpA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3lrp ADP-RIBOSYLATION
FACTOR 1
(Plasmodium
falciparum) 		4 / 6 ARG A  75
GLY A  70
GLU A 105
GLU A 106
 None
 1.06A 3k9fA-3lrpA:
undetectable
3k9fB-3lrpA:
undetectable
3k9fD-3lrpA:
2.2		 3k9fA-3lrpA:
18.28
3k9fB-3lrpA:
18.28
3k9fD-3lrpA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 3lrp ADP-RIBOSYLATION
FACTOR 1
(Plasmodium
falciparum) 		4 / 7 VAL A  56
PHE A  58
PHE A 170
ILE A  33
 None
 1.00A 3zjqB-3lrpA:
undetectable		 3zjqB-3lrpA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 3lrp ADP-RIBOSYLATION
FACTOR 1
(Plasmodium
falciparum) 		5 / 12 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 182 (-3.1A)
GDP  A 182 (-4.3A)
None
None
None
 0.92A 4ax8A-3lrpA:
3.3		 4ax8A-3lrpA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 3lrp ADP-RIBOSYLATION
FACTOR 1
(Plasmodium
falciparum) 		5 / 12 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 182 (-3.1A)
GDP  A 182 (-4.3A)
None
None
None
 0.94A 4aztA-3lrpA:
2.4		 4aztA-3lrpA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 3lrp ADP-RIBOSYLATION
FACTOR 1
(Plasmodium
falciparum) 		5 / 12 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 182 (-3.1A)
GDP  A 182 (-4.3A)
None
None
None
 0.91A 4azvA-3lrpA:
2.1		 4azvA-3lrpA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 3lrp ADP-RIBOSYLATION
FACTOR 1
(Plasmodium
falciparum) 		5 / 12 GLY A  29
ALA A  27
ILE A  33
VAL A  91
ILE A  89
 GDP  A 182 (-3.1A)
GDP  A 182 (-4.3A)
None
None
None
 0.97A 4uw0A-3lrpA:
2.5		 4uw0A-3lrpA:
15.25