SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lrv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3lrv PRE-MRNA-SPLICING
FACTOR 19
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 497
PHE A 496
ASN A 187
ASP A 494
 None
None
SO4  A  69 (-4.3A)
None
 1.29A 1p6kB-3lrvA:
undetectable		 1p6kB-3lrvA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3lrv PRE-MRNA-SPLICING
FACTOR 19
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 497
PHE A 496
ASN A 187
ASP A 494
 None
None
SO4  A  69 (-4.3A)
None
 1.22A 1rs6B-3lrvA:
undetectable		 1rs6B-3lrvA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3lrv PRE-MRNA-SPLICING
FACTOR 19
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 497
PHE A 496
ASN A 187
ASP A 494
 None
None
SO4  A  69 (-4.3A)
None
 1.30A 1zzqB-3lrvA:
undetectable		 1zzqB-3lrvA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 3lrv PRE-MRNA-SPLICING
FACTOR 19
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 337
GLY A 336
ILE A 289
SER A 334
PRO A 350
 None
 1.23A 3bjwF-3lrvA:
undetectable		 3bjwF-3lrvA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3lrv PRE-MRNA-SPLICING
FACTOR 19
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 485
ASP A 227
THR A 230
ALA A 500
GLU A 181
 None
 1.08A 3g88A-3lrvA:
undetectable		 3g88A-3lrvA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G88_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3lrv PRE-MRNA-SPLICING
FACTOR 19
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 485
ASP A 227
THR A 230
ALA A 500
GLU A 181
 None
 1.08A 3g88B-3lrvA:
undetectable		 3g88B-3lrvA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3lrv PRE-MRNA-SPLICING
FACTOR 19
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 485
ASP A 227
THR A 230
ALA A 500
GLU A 181
 None
 1.02A 3g8bA-3lrvA:
undetectable		 3g8bA-3lrvA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 3lrv PRE-MRNA-SPLICING
FACTOR 19
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 497
PHE A 496
ASN A 187
ASP A 494
 None
None
SO4  A  69 (-4.3A)
None
 1.31A 3n66B-3lrvA:
undetectable		 3n66B-3lrvA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 3lrv PRE-MRNA-SPLICING
FACTOR 19
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 488
ASP A 478
GLY A 485
ILE A 447
ILE A 436
 None
 0.96A 3s43A-3lrvA:
undetectable		 3s43A-3lrvA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 3lrv PRE-MRNA-SPLICING
FACTOR 19
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 484
ALA A 500
SER A 228
GLU A 181
 None
 0.89A 3u9hA-3lrvA:
undetectable		 3u9hA-3lrvA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrv PRE-MRNA-SPLICING
FACTOR 19
(Saccharomyces
cerevisiae) 		4 / 7 ASN A 497
PHE A 496
ASN A 187
ASP A 494
 None
None
SO4  A  69 (-4.3A)
None
 1.32A 4kcnB-3lrvA:
undetectable		 4kcnB-3lrvA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3lrv PRE-MRNA-SPLICING
FACTOR 19
(Saccharomyces
cerevisiae) 		4 / 8 PRO A 196
VAL A 210
VAL A 337
GLY A 336
 None
 0.93A 4mk4A-3lrvA:
undetectable		 4mk4A-3lrvA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 3lrv PRE-MRNA-SPLICING
FACTOR 19
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 480
GLU A 392
GLU A 379
 None
 0.92A 5jsdB-3lrvA:
undetectable
5jsdC-3lrvA:
undetectable		 5jsdB-3lrvA:
17.80
5jsdC-3lrvA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrv PRE-MRNA-SPLICING
FACTOR 19
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 497
PHE A 496
ASN A 187
ASP A 494
 None
None
SO4  A  69 (-4.3A)
None
 1.29A 5vunA-3lrvA:
undetectable		 5vunA-3lrvA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrv PRE-MRNA-SPLICING
FACTOR 19
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 497
PHE A 496
ASN A 187
ASP A 494
 None
None
SO4  A  69 (-4.3A)
None
 1.27A 5vunB-3lrvA:
undetectable		 5vunB-3lrvA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrv PRE-MRNA-SPLICING
FACTOR 19
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 497
PHE A 496
ASN A 187
ASP A 494
 None
None
SO4  A  69 (-4.3A)
None
 1.28A 5vuoB-3lrvA:
undetectable		 5vuoB-3lrvA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3lrv PRE-MRNA-SPLICING
FACTOR 19
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 333
ARG A 308
THR A 310
 None
 0.79A 5z84J-3lrvA:
undetectable		 5z84J-3lrvA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3lrv PRE-MRNA-SPLICING
FACTOR 19
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 497
PHE A 496
ASN A 187
ASP A 494
 None
None
SO4  A  69 (-4.3A)
None
 1.26A 6auuB-3lrvA:
undetectable		 6auuB-3lrvA:
22.43