SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ls2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 3ls2 S-FORMYLGLUTATHIONE
HYDROLASE
(Pseudoalteromona
s
haloplanktis) 		5 / 11 GLN A  17
ALA A  32
VAL A  10
LEU A 271
ALA A  71
 None
 1.23A 1n4hA-3ls2A:
undetectable		 1n4hA-3ls2A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 3ls2 S-FORMYLGLUTATHIONE
HYDROLASE
(Pseudoalteromona
s
haloplanktis) 		4 / 7 TYR A 122
HIS A  20
LEU A   2
ILE A 131
 None
 1.14A 1tuvA-3ls2A:
undetectable		 1tuvA-3ls2A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3ls2 S-FORMYLGLUTATHIONE
HYDROLASE
(Pseudoalteromona
s
haloplanktis) 		5 / 11 SER A 264
ILE A 143
ALA A 169
PHE A 170
PHE A  61
 None
 1.26A 1uduA-3ls2A:
undetectable		 1uduA-3ls2A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3ls2 S-FORMYLGLUTATHIONE
HYDROLASE
(Pseudoalteromona
s
haloplanktis) 		5 / 11 LEU A 248
HIS A 274
HIS A 270
PHE A 273
GLY A 145
 None
 1.15A 1zz1A-3ls2A:
undetectable		 1zz1A-3ls2A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3ls2 S-FORMYLGLUTATHIONE
HYDROLASE
(Pseudoalteromona
s
haloplanktis) 		5 / 12 LEU A 248
HIS A 274
HIS A 270
PHE A 273
GLY A 145
 None
 1.14A 1zz1B-3ls2A:
undetectable
1zz1C-3ls2A:
undetectable		 1zz1B-3ls2A:
23.36
1zz1C-3ls2A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C2B_E_SAME500_0
(THREONINE SYNTHASE
1, CHLOROPLASTIC)		 3ls2 S-FORMYLGLUTATHIONE
HYDROLASE
(Pseudoalteromona
s
haloplanktis) 		5 / 11 SER A 171
GLY A 150
SER A 202
LEU A 250
ASP A 225
 None
 1.12A 2c2bE-3ls2A:
undetectable
2c2bF-3ls2A:
1.2		 2c2bE-3ls2A:
19.38
2c2bF-3ls2A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3ls2 S-FORMYLGLUTATHIONE
HYDROLASE
(Pseudoalteromona
s
haloplanktis) 		5 / 12 LEU A  54
ILE A 173
GLN A 231
ASP A  97
LEU A 190
 None
 1.07A 2jn3A-3ls2A:
undetectable		 2jn3A-3ls2A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 3ls2 S-FORMYLGLUTATHIONE
HYDROLASE
(Pseudoalteromona
s
haloplanktis) 		4 / 4 ALA A 153
TYR A  49
ALA A 167
TYR A 164
 None
 1.25A 2wlkA-3ls2A:
undetectable
2wlkB-3ls2A:
undetectable		 2wlkA-3ls2A:
19.57
2wlkB-3ls2A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 3ls2 S-FORMYLGLUTATHIONE
HYDROLASE
(Pseudoalteromona
s
haloplanktis) 		5 / 12 PRO A 128
ASN A 107
ILE A 131
TYR A  49
ILE A 156
 None
 1.35A 3q5pA-3ls2A:
undetectable		 3q5pA-3ls2A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5R_A_KANA2002_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 3ls2 S-FORMYLGLUTATHIONE
HYDROLASE
(Pseudoalteromona
s
haloplanktis) 		5 / 11 PRO A 128
ASN A 107
ILE A 131
TYR A  49
ILE A 156
 None
 1.38A 3q5rA-3ls2A:
undetectable		 3q5rA-3ls2A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3ls2 S-FORMYLGLUTATHIONE
HYDROLASE
(Pseudoalteromona
s
haloplanktis) 		4 / 8 PHE A 262
TYR A 260
GLY A 150
ILE A 173
 None
 0.98A 4qoiA-3ls2A:
undetectable
4qoiB-3ls2A:
2.2		 4qoiA-3ls2A:
20.34
4qoiB-3ls2A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 3ls2 S-FORMYLGLUTATHIONE
HYDROLASE
(Pseudoalteromona
s
haloplanktis) 		5 / 11 GLY A  53
PHE A 262
ASP A 225
ASN A 226
TYR A 256
 None
 1.47A 4rtrA-3ls2A:
undetectable		 4rtrA-3ls2A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ls2 S-FORMYLGLUTATHIONE
HYDROLASE
(Pseudoalteromona
s
haloplanktis) 		5 / 12 TYR A 260
PHE A 104
GLY A 182
HIS A 146
MET A 148
 None
 1.35A 5esgA-3ls2A:
undetectable		 5esgA-3ls2A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ls2 S-FORMYLGLUTATHIONE
HYDROLASE
(Pseudoalteromona
s
haloplanktis) 		5 / 12 TYR A  96
PHE A 104
GLY A 182
HIS A 146
MET A 148
 None
 1.26A 5eslA-3ls2A:
undetectable		 5eslA-3ls2A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_A_Z80A401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3ls2 S-FORMYLGLUTATHIONE
HYDROLASE
(Pseudoalteromona
s
haloplanktis) 		5 / 11 ILE A  78
VAL A  10
ASP A  58
TRP A  50
ALA A  65
 None
 1.00A 5lg3A-3ls2A:
undetectable		 5lg3A-3ls2A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3ls2 S-FORMYLGLUTATHIONE
HYDROLASE
(Pseudoalteromona
s
haloplanktis) 		5 / 12 TYR A  96
PHE A 104
GLY A 182
HIS A 146
MET A 148
 None
 1.37A 5v5zA-3ls2A:
undetectable		 5v5zA-3ls2A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)		 3ls2 S-FORMYLGLUTATHIONE
HYDROLASE
(Pseudoalteromona
s
haloplanktis) 		5 / 12 MET A 148
LEU A  54
ARG A  86
TYR A 122
ASP A  94
 None
 1.47A 5vlmC-3ls2A:
undetectable		 5vlmC-3ls2A:
20.40