SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lsc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZM_A_MZMA262_1
(CARBONIC ANHYDRASE I)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 8 HIS A 238
HIS A 274
THR A 325
HIS A  63
 ZN  A 458 (-3.2A)
AOO  A 457 ( 4.6A)
AOO  A 457 (-4.0A)
ZN  A 458 (-3.3A)
 0.85A 1bzmA-3lscA:
undetectable		 1bzmA-3lscA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 296
HIS A 238
SER A 161
THR A 324
ARG A 302
 None
ZN  A 458 (-3.2A)
None
None
None
 1.20A 1jffB-3lscA:
3.0		 1jffB-3lscA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_1
(DNA GYRASE SUBUNIT B)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 ASP A 143
GLU A 147
ARG A 108
ARG A 112
THR A 150
 None
 1.42A 1kijA-3lscA:
undetectable		 1kijA-3lscA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 VAL A  89
GLY A  88
ALA A  70
ILE A 107
HIS A  65
 None
None
None
None
ZN  A 458 ( 3.2A)
 1.19A 1kxhA-3lscA:
undetectable		 1kxhA-3lscA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 9 LEU A 383
VAL A  33
ILE A  48
VAL A  35
ILE A  32
 None
 1.01A 1ohrB-3lscA:
undetectable		 1ohrB-3lscA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 8 HIS A 130
ASP A 128
THR A 150
PHE A 156
 None
 1.08A 1p7lC-3lscA:
undetectable		 1p7lC-3lscA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 8 HIS A 130
ASP A 128
THR A 150
PHE A 156
 None
 1.08A 1p7lD-3lscA:
undetectable		 1p7lD-3lscA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 8 HIS A 130
ASP A 128
THR A 150
PHE A 156
 None
 1.09A 1rg9A-3lscA:
undetectable		 1rg9A-3lscA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 8 HIS A 130
ASP A 128
THR A 150
PHE A 156
 None
 1.10A 1rg9B-3lscA:
undetectable		 1rg9B-3lscA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 8 HIS A 130
ASP A 128
THR A 150
PHE A 156
 None
 1.09A 1rg9C-3lscA:
undetectable		 1rg9C-3lscA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 8 HIS A 130
ASP A 128
THR A 150
PHE A 156
 None
 1.08A 1rg9D-3lscA:
undetectable		 1rg9D-3lscA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 335
GLY A 122
GLY A  58
LEU A 380
GLY A 381
 None
 1.20A 1y4lA-3lscA:
undetectable		 1y4lA-3lscA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 GLY A   6
VAL A  35
LEU A   3
LEU A  39
LEU A 422
 None
 1.25A 1ya4B-3lscA:
2.3		 1ya4B-3lscA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		3 / 3 SER A  43
VAL A  33
LEU A  26
 None
 0.65A 1yajG-3lscA:
1.8		 1yajG-3lscA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 335
LEU A 339
GLY A 321
ALA A 294
ALA A 273
 None
 1.04A 2bm9A-3lscA:
undetectable		 2bm9A-3lscA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 335
LEU A 339
GLY A 321
ALA A 294
ALA A 273
 None
 1.02A 2bm9D-3lscA:
undetectable		 2bm9D-3lscA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 335
LEU A 339
GLY A 321
ALA A 294
ALA A 273
 None
 0.99A 2bm9E-3lscA:
undetectable		 2bm9E-3lscA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 335
LEU A 339
GLY A 321
ALA A 294
ALA A 273
 None
 1.06A 2bm9F-3lscA:
undetectable		 2bm9F-3lscA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 335
LEU A 339
GLY A 321
ALA A 294
ALA A 273
 None
 0.96A 2br4A-3lscA:
undetectable		 2br4A-3lscA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_C_SAMC301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 335
LEU A 339
GLY A 321
ALA A 294
ALA A 273
 None
 0.99A 2br4C-3lscA:
undetectable		 2br4C-3lscA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 335
LEU A 339
GLY A 321
ALA A 294
ALA A 273
 None
 0.98A 2br4D-3lscA:
undetectable		 2br4D-3lscA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 335
LEU A 339
GLY A 321
ALA A 294
ALA A 273
 None
 0.96A 2br4E-3lscA:
undetectable		 2br4E-3lscA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 335
LEU A 339
GLY A 321
ALA A 294
ALA A 273
 None
 0.98A 2br4F-3lscA:
undetectable		 2br4F-3lscA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 383
ALA A 389
ILE A  48
VAL A  35
ILE A  32
 None
 1.02A 2f80A-3lscA:
undetectable		 2f80A-3lscA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 383
ALA A 389
VAL A  33
ILE A  48
VAL A  35
 None
 1.01A 2f80A-3lscA:
undetectable		 2f80A-3lscA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F81_A_017A302_1
(POL POLYPROTEIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 383
ALA A 389
VAL A  33
ILE A  48
VAL A  35
 None
 1.01A 2f81A-3lscA:
undetectable		 2f81A-3lscA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 5 ASP A  41
LEU A   3
LYS A   1
ARG A   5
 None
 1.07A 2gj5A-3lscA:
undetectable		 2gj5A-3lscA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 383
ALA A 389
ILE A  48
VAL A  35
ILE A  32
 None
 0.96A 2hs2A-3lscA:
undetectable		 2hs2A-3lscA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 296
HIS A 238
SER A 161
THR A 324
ARG A 302
 None
ZN  A 458 (-3.2A)
None
None
None
 1.20A 2hxfB-3lscA:
2.7		 2hxfB-3lscA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 296
HIS A 238
SER A 161
THR A 324
ARG A 302
 None
ZN  A 458 (-3.2A)
None
None
None
 1.20A 2hxhB-3lscA:
2.7		 2hxhB-3lscA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		6 / 12 LEU A 383
ALA A 389
VAL A  33
ILE A  48
VAL A  35
ILE A  32
 None
 1.15A 2ienA-3lscA:
undetectable		 2ienA-3lscA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IEN_B_017B402_1
(PROTEASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		6 / 12 LEU A 383
ASP A  28
VAL A  33
ILE A  48
VAL A  35
ILE A  32
 None
 1.50A 2ienA-3lscA:
undetectable		 2ienA-3lscA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 4 PRO A 299
ASP A 338
ASP A 418
ASP A 331
 None
 1.44A 2nyuA-3lscA:
undetectable		 2nyuA-3lscA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1003_0
(ALDEHYDE
DEHYDROGENASE A)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 5 ILE A 206
LEU A 191
ALA A 207
PHE A 133
 None
 1.02A 2opxA-3lscA:
undetectable		 2opxA-3lscA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 296
HIS A 238
SER A 161
THR A 324
ARG A 302
 None
ZN  A 458 (-3.2A)
None
None
None
 1.20A 2p4nB-3lscA:
2.6		 2p4nB-3lscA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 383
VAL A  33
ILE A  48
VAL A  35
ILE A  32
 None
 0.91A 2pymA-3lscA:
undetectable		 2pymA-3lscA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 383
VAL A  33
ILE A  48
VAL A  35
ILE A  32
 None
 0.91A 2pymB-3lscA:
undetectable		 2pymB-3lscA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 383
VAL A  33
ILE A  48
VAL A  35
ILE A  32
 None
 0.93A 2pynA-3lscA:
undetectable		 2pynA-3lscA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 383
VAL A  33
ILE A  48
VAL A  35
ILE A  32
 None
 0.92A 2pynB-3lscA:
undetectable		 2pynB-3lscA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 9 ALA A 389
VAL A  33
ILE A  48
VAL A  35
ILE A  32
 None
 1.06A 2q5kA-3lscA:
undetectable		 2q5kA-3lscA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 383
VAL A  33
ILE A  48
VAL A  35
ILE A  32
 None
 0.92A 2q63B-3lscA:
undetectable		 2q63B-3lscA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_B_REAB1445_1
(PUTATIVE CYTOCHROME
P450 120)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 ALA A 144
PHE A 102
THR A 448
GLY A  69
PRO A 453
 None
 1.19A 2ve3B-3lscA:
undetectable		 2ve3B-3lscA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 296
HIS A 238
SER A 161
THR A 324
ARG A 302
 None
ZN  A 458 (-3.2A)
None
None
None
 1.20A 2wbeB-3lscA:
2.3		 2wbeB-3lscA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 5 ARG A 108
ALA A 144
ASP A 143
GLU A 147
 None
 0.85A 2xrzA-3lscA:
undetectable		 2xrzA-3lscA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		6 / 12 LEU A 383
ALA A 389
VAL A  33
ILE A  48
VAL A  35
ILE A  32
 None
 1.15A 3bvbA-3lscA:
undetectable		 3bvbA-3lscA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 296
HIS A 238
SER A 161
THR A 324
ARG A 302
 None
ZN  A 458 (-3.2A)
None
None
None
 1.20A 3dcoB-3lscA:
2.4		 3dcoB-3lscA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 296
HIS A 238
SER A 161
THR A 324
ARG A 302
 None
ZN  A 458 (-3.2A)
None
None
None
 1.21A 3edlB-3lscA:
2.5		 3edlB-3lscA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		3 / 3 TYR A 240
TYR A 313
ILE A 293
 None
 0.77A 3eteA-3lscA:
undetectable
3eteB-3lscA:
undetectable		 3eteA-3lscA:
22.33
3eteB-3lscA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		6 / 12 ALA A 367
GLY A 370
LEU A 375
LEU A 364
SER A  62
GLY A 323
 None
 1.43A 3g2oA-3lscA:
undetectable		 3g2oA-3lscA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 296
HIS A 238
SER A 161
THR A 324
ARG A 302
 None
ZN  A 458 (-3.2A)
None
None
None
 1.19A 3iz0B-3lscA:
2.3		 3iz0B-3lscA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		6 / 12 LEU A 383
ALA A 389
VAL A  33
ILE A  48
VAL A  35
ILE A  32
 None
 1.13A 3jw2A-3lscA:
undetectable		 3jw2A-3lscA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		6 / 12 LEU A 383
ALA A 389
VAL A  33
ILE A  48
VAL A  35
ILE A  32
 None
 1.16A 3k4vB-3lscA:
undetectable		 3k4vB-3lscA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 ASP A 143
GLU A 147
ARG A 108
ARG A 112
THR A 150
 None
 1.49A 3lpsA-3lscA:
undetectable		 3lpsA-3lscA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 SER A 161
HIS A 130
PHE A 102
VAL A  89
TRP A  85
 None
 1.31A 3lxeA-3lscA:
undetectable		 3lxeA-3lscA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 SER A 161
HIS A 130
PHE A 102
VAL A  89
TRP A  85
 None
 1.30A 3lxeB-3lscA:
undetectable		 3lxeB-3lscA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZU_A_017A200_2
(HIV-1 PROTEASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		6 / 12 LEU A 383
ALA A 389
VAL A  33
ILE A  48
VAL A  35
ILE A  32
 None
 1.25A 3lzuB-3lscA:
undetectable		 3lzuB-3lscA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 383
ALA A 389
ILE A  48
VAL A  35
ILE A  32
 None
 1.05A 3nu3A-3lscA:
undetectable		 3nu3A-3lscA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 TYR A  67
ALA A 328
GLY A  69
GLY A 326
TRP A  85
 AOO  A 457 (-4.7A)
None
None
None
None
 1.15A 3ou6B-3lscA:
undetectable		 3ou6B-3lscA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 TYR A  67
ALA A 328
GLY A  69
GLY A 326
TRP A  85
 AOO  A 457 (-4.7A)
None
None
None
None
 1.16A 3ou7A-3lscA:
undetectable		 3ou7A-3lscA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 TYR A  67
ALA A 328
GLY A  69
GLY A 326
TRP A  85
 AOO  A 457 (-4.7A)
None
None
None
None
 1.18A 3ou7D-3lscA:
undetectable		 3ou7D-3lscA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		6 / 12 LEU A 383
ALA A 389
VAL A  33
ILE A  48
VAL A  35
ILE A  32
 None
 1.10A 3tl9B-3lscA:
undetectable		 3tl9B-3lscA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_1
(ADENOSINE KINASE,
PUTATIVE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 441
GLY A 122
GLY A 121
VAL A 431
LEU A 116
 None
 1.01A 3uq6A-3lscA:
undetectable		 3uq6A-3lscA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V35_A_NTIA317_1
(ALDOSE REDUCTASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 8 TRP A 265
TRP A 257
PHE A 239
PRO A 210
 None
 1.46A 3v35A-3lscA:
4.2		 3v35A-3lscA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 441
GLY A 122
GLY A 121
VAL A 431
LEU A 116
 None
 0.98A 3vaqA-3lscA:
undetectable		 3vaqA-3lscA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_1
(PUTATIVE ADENOSINE
KINASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 441
GLY A 122
GLY A 121
VAL A 431
LEU A 116
 None
 0.99A 3vasA-3lscA:
undetectable		 3vasA-3lscA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 441
GLY A 122
GLY A 121
VAL A 431
LEU A 116
 None
 0.96A 3vasB-3lscA:
undetectable		 3vasB-3lscA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 5 ASP A 379
GLU A 199
GLY A 202
ASP A 390
 None
 1.33A 3w9tD-3lscA:
undetectable		 3w9tD-3lscA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 6 ARG A 419
ASP A 440
GLU A 109
LEU A 120
 None
 1.39A 4ax8A-3lscA:
undetectable		 4ax8A-3lscA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 7 PRO A 210
SER A 161
VAL A 213
MET A 163
 None
 1.46A 4kmmA-3lscA:
undetectable		 4kmmA-3lscA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 10 GLU A 312
ILE A 318
VAL A 320
ALA A 275
ILE A 293
 None
 1.01A 4lbgA-3lscA:
3.1		 4lbgA-3lscA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 GLY A   6
LEU A   7
ALA A  34
VAL A  10
VAL A 424
 None
 1.13A 4wnwB-3lscA:
undetectable		 4wnwB-3lscA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 ASP A 244
HIS A 238
HIS A  65
LEU A  86
TRP A  85
 None
ZN  A 458 (-3.2A)
ZN  A 458 ( 3.2A)
AOO  A 457 ( 4.5A)
None
 1.42A 4yhaA-3lscA:
undetectable		 4yhaA-3lscA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 4 ASP A  49
GLY A   6
ASP A  24
ASP A  41
 None
 1.05A 5e72A-3lscA:
undetectable		 5e72A-3lscA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		3 / 3 ASN A 433
ASP A  49
GLY A  50
 None
 0.46A 5fctB-3lscA:
undetectable		 5fctB-3lscA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 9 LEU A 336
LEU A  59
ALA A 342
MET A 366
ALA A 367
 None
 1.44A 5g44A-3lscA:
undetectable		 5g44A-3lscA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 296
HIS A 238
SER A 161
THR A 324
ARG A 302
 None
ZN  A 458 (-3.2A)
None
None
None
 1.16A 5hnwB-3lscA:
2.4		 5hnwB-3lscA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 296
HIS A 238
SER A 161
THR A 324
ARG A 302
 None
ZN  A 458 (-3.2A)
None
None
None
 1.21A 5hnyB-3lscA:
3.0		 5hnyB-3lscA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 296
HIS A 238
SER A 161
THR A 324
ARG A 302
 None
ZN  A 458 (-3.2A)
None
None
None
 1.15A 5hnzB-3lscA:
2.9		 5hnzB-3lscA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 5 PRO A 299
HIS A 236
LEU A 115
TYR A  67
 None
None
None
AOO  A 457 (-4.7A)
 1.46A 5igjA-3lscA:
undetectable		 5igjA-3lscA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_1
(ADENOSINE KINASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		6 / 12 GLY A 323
ASN A  61
ALA A 342
LEU A 363
ASN A 330
GLY A 333
 None
 1.34A 5kb5A-3lscA:
undetectable		 5kb5A-3lscA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KM8_B_L8PB201_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 2,
MITOCHONDRIAL)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 8 ALA A 159
SER A 161
HIS A  65
HIS A  63
 None
None
ZN  A 458 ( 3.2A)
ZN  A 458 (-3.3A)
 0.97A 5km8A-3lscA:
undetectable
5km8B-3lscA:
undetectable		 5km8A-3lscA:
14.91
5km8B-3lscA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 4 HIS A  65
HIS A 236
HIS A  63
HIS A 238
 ZN  A 458 ( 3.2A)
None
ZN  A 458 (-3.3A)
ZN  A 458 (-3.2A)
 1.02A 5mhxA-3lscA:
undetectable		 5mhxA-3lscA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 4 HIS A  65
HIS A 236
HIS A  63
HIS A 238
 ZN  A 458 ( 3.2A)
None
ZN  A 458 (-3.3A)
ZN  A 458 (-3.2A)
 1.02A 5mhyA-3lscA:
undetectable		 5mhyA-3lscA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 4 HIS A  65
HIS A 236
HIS A  63
HIS A 238
 ZN  A 458 ( 3.2A)
None
ZN  A 458 (-3.3A)
ZN  A 458 (-3.2A)
 1.02A 5mhzA-3lscA:
undetectable		 5mhzA-3lscA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 4 HIS A  65
HIS A 236
HIS A  63
HIS A 238
 ZN  A 458 ( 3.2A)
None
ZN  A 458 (-3.3A)
ZN  A 458 (-3.2A)
 1.02A 5mi1A-3lscA:
undetectable		 5mi1A-3lscA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 4 HIS A  65
HIS A 236
HIS A  63
HIS A 238
 ZN  A 458 ( 3.2A)
None
ZN  A 458 (-3.3A)
ZN  A 458 (-3.2A)
 1.01A 5mi2A-3lscA:
undetectable		 5mi2A-3lscA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 4 HIS A  65
HIS A 236
HIS A  63
HIS A 238
 ZN  A 458 ( 3.2A)
None
ZN  A 458 (-3.3A)
ZN  A 458 (-3.2A)
 1.02A 5miaA-3lscA:
undetectable		 5miaA-3lscA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 4 HIS A  65
HIS A 236
HIS A  63
HIS A 238
 ZN  A 458 ( 3.2A)
None
ZN  A 458 (-3.3A)
ZN  A 458 (-3.2A)
 1.01A 5mibA-3lscA:
undetectable		 5mibA-3lscA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 4 HIS A  65
HIS A 236
HIS A  63
HIS A 238
 ZN  A 458 ( 3.2A)
None
ZN  A 458 (-3.3A)
ZN  A 458 (-3.2A)
 1.01A 5micA-3lscA:
undetectable		 5micA-3lscA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 4 HIS A  65
HIS A 236
HIS A  63
HIS A 238
 ZN  A 458 ( 3.2A)
None
ZN  A 458 (-3.3A)
ZN  A 458 (-3.2A)
 1.02A 5mieA-3lscA:
undetectable		 5mieA-3lscA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 8 HIS A 130
ASP A 128
THR A 150
PHE A 156
 None
 1.09A 5t8sB-3lscA:
undetectable		 5t8sB-3lscA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 4 LEU A 335
GLY A 323
SER A  62
SER A 371
 None
 1.19A 5uunA-3lscA:
undetectable		 5uunA-3lscA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 411
LEU A 364
ALA A 367
SER A 371
GLY A 333
 None
 0.92A 6b0iB-3lscA:
undetectable		 6b0iB-3lscA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA814_0
(UNCHARACTERIZED
PROTEIN)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		4 / 5 GLN A  64
ASN A  61
THR A 324
LEU A 296
 None
 1.39A 6d8pA-3lscA:
1.7		 6d8pA-3lscA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 3lsc TRIAZINE HYDROLASE
(Paenarthrobacter
aurescens) 		5 / 12 LEU A  59
GLY A 323
GLY A 332
LEU A 115
ILE A 123
 None
 0.84A 6dh6B-3lscA:
undetectable		 6dh6B-3lscA:
11.16