SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lsp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 3lsp DEST
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 169
ILE A 121
TYR A 115
VAL A  67
 None
 1.11A 1db1A-3lspA:
undetectable		 1db1A-3lspA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 3lsp DEST
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 169
PHE A 166
ALA A 167
LEU A 172
 None
 1.03A 1ukbA-3lspA:
undetectable		 1ukbA-3lspA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 3lsp DEST
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 117
LEU A 119
GLU A 113
ASP A  57
 None
 0.91A 3ps9A-3lspA:
undetectable		 3ps9A-3lspA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3lsp DEST
(Pseudomonas
aeruginosa) 		4 / 6 GLY A 200
GLY A 201
MET A 146
ILE A 197
 None
 0.94A 4fglD-3lspA:
undetectable		 4fglD-3lspA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 3lsp DEST
(Pseudomonas
aeruginosa) 		4 / 7 ALA A  20
GLU A  66
LEU A  63
LEU A  59
 None
 0.98A 4iomA-3lspA:
undetectable		 4iomA-3lspA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3lsp DEST
(Pseudomonas
aeruginosa) 		5 / 12 PHE A  96
GLU A  66
SER A 105
LEU A 108
ILE A 173
 OLA  A 221 ( 4.6A)
None
SO4  A 222 ( 4.4A)
None
None
 1.41A 4k39A-3lspA:
undetectable		 4k39A-3lspA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 3lsp DEST
(Pseudomonas
aeruginosa) 		3 / 3 ASN A  81
ALA A  91
ARG A  94
 None
 0.66A 5cvtB-3lspA:
undetectable		 5cvtB-3lspA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3lsp DEST
(Pseudomonas
aeruginosa) 		4 / 4 GLU A 171
PRO A 170
ILE A 173
LEU A 172
 None
 1.11A 5m45A-3lspA:
2.0		 5m45A-3lspA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3lsp DEST
(Pseudomonas
aeruginosa) 		4 / 4 GLU A 171
PRO A 170
ILE A 173
LEU A 172
 None
 1.15A 5m45D-3lspA:
2.1		 5m45D-3lspA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3lsp DEST
(Pseudomonas
aeruginosa) 		4 / 4 GLU A 171
PRO A 170
ILE A 173
LEU A 172
 None
 1.09A 5m45G-3lspA:
undetectable		 5m45G-3lspA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 3lsp DEST
(Pseudomonas
aeruginosa) 		4 / 4 GLU A 171
PRO A 170
ILE A 173
LEU A 172
 None
 1.16A 5m45J-3lspA:
undetectable		 5m45J-3lspA:
14.29