SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lss'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 3lss SERYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		4 / 6 ILE A 429
PRO A 449
LEU A 350
ILE A 436
 None
 1.02A 2q83B-3lssA:
3.1		 2q83B-3lssA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMQ_A_BEZA3_0
(PROTEIN NDRG2)		 3lss SERYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		4 / 7 GLN A   6
PHE A   8
ARG A   9
ARG A 129
 None
 1.44A 2qmqA-3lssA:
undetectable		 2qmqA-3lssA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3lss SERYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		4 / 6 PRO A 325
SER A 324
GLU A 280
TYR A 403
 None
 1.33A 2x7hA-3lssA:
undetectable		 2x7hA-3lssA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3lss SERYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		4 / 8 ASP A 371
ASN A 154
GLU A 373
ASP A 149
 ATP  A 501 ( 4.5A)
None
None
None
 1.07A 4gkiE-3lssA:
undetectable
4gkiG-3lssA:
undetectable		 4gkiE-3lssA:
20.33
4gkiG-3lssA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 3lss SERYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		4 / 6 TYR A 222
GLU A 343
THR A 339
LEU A 217
 None
 1.30A 4qzuC-3lssA:
undetectable		 4qzuC-3lssA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3lss SERYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		6 / 12 ALA A 374
PRO A 351
GLY A 349
ALA A 428
LYS A 316
GLU A 318
 None
None
None
ATP  A 501 (-3.2A)
None
None
 1.45A 5c0oG-3lssA:
undetectable		 5c0oG-3lssA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 3lss SERYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		4 / 8 TRP A 331
GLU A 329
HIS A 420
THR A 425
 None
None
None
ATP  A 501 (-3.7A)
 1.32A 5hqaA-3lssA:
undetectable		 5hqaA-3lssA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3lss SERYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		5 / 12 ILE A 462
GLY A 200
GLU A 438
ALA A 208
ILE A 308
 None
 1.08A 5igyA-3lssA:
undetectable		 5igyA-3lssA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3lss SERYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		5 / 12 ILE A 462
GLY A 200
GLU A 438
ALA A 208
ILE A 308
 None
 1.12A 5ih0A-3lssA:
undetectable		 5ih0A-3lssA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 3lss SERYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		5 / 10 ARG A 295
GLU A 297
PHE A 314
ALA A 428
GLU A 384
 ATP  A 501 (-2.9A)
ATP  A 501 (-3.3A)
ATP  A 501 (-3.6A)
ATP  A 501 (-3.2A)
ATP  A 501 (-2.5A)
 1.22A 6bniA-3lssA:
10.4		 6bniA-3lssA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 3lss SERYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		5 / 10 ARG A 295
GLU A 297
PHE A 314
GLU A 384
ARG A 431
 ATP  A 501 (-2.9A)
ATP  A 501 (-3.3A)
ATP  A 501 (-3.6A)
ATP  A 501 (-2.5A)
ATP  A 501 (-3.9A)
 0.64A 6bniA-3lssA:
10.4		 6bniA-3lssA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 3lss SERYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		5 / 10 ARG A 295
GLU A 297
PHE A 314
GLU A 384
ARG A 431
 ATP  A 501 (-2.9A)
ATP  A 501 (-3.3A)
ATP  A 501 (-3.6A)
ATP  A 501 (-2.5A)
ATP  A 501 (-3.9A)
 0.65A 6bniB-3lssA:
12.0		 6bniB-3lssA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_2
(PROTEASE)		 3lss SERYL-TRNA
SYNTHETASE
(Trypanosoma
brucei) 		3 / 3 LEU A 350
ASP A 371
ILE A 338
 None
ATP  A 501 ( 4.5A)
None
 0.62A 6dh0B-3lssA:
undetectable		 6dh0B-3lssA:
10.88