SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lst'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		5 / 11 LEU A 173
GLY A 177
VAL A 185
ASP A 187
VAL A 247
 None
None
None
SAH  A 346 ( 4.5A)
None
 1.16A 1akdA-3lstA:
undetectable		 1akdA-3lstA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		6 / 10 GLY A 189
ASP A 212
VAL A 216
ASP A 237
ASN A 256
TRP A 257
 SAH  A 346 (-4.0A)
SAH  A 346 (-3.0A)
None
SAH  A 346 (-3.6A)
None
None
 0.51A 1fpqA-3lstA:
18.0		 1fpqA-3lstA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		4 / 4 ALA A 186
VAL A 185
ALA A 245
HIS A 244
 None
 1.16A 1q23K-3lstA:
undetectable		 1q23K-3lstA:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		5 / 8 ASP A 187
GLY A 190
GLY A 193
GLY A 194
LEU A 196
 SAH  A 346 ( 4.5A)
SAH  A 346 (-3.6A)
None
None
None
 0.43A 1qzzA-3lstA:
5.0		 1qzzA-3lstA:
34.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		7 / 12 GLY A 189
GLY A 190
GLY A 191
ASP A 237
PHE A 238
ASN A 256
TRP A 257
 SAH  A 346 (-4.0A)
SAH  A 346 (-3.6A)
SAH  A 346 ( 3.7A)
SAH  A 346 (-3.6A)
SAH  A 346 (-3.4A)
None
None
 0.49A 1qzzA-3lstA:
3.0		 1qzzA-3lstA:
34.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		7 / 12 GLY A 189
GLY A 190
GLY A 191
ASP A 237
PHE A 238
ASN A 256
TRP A 257
 SAH  A 346 (-4.0A)
SAH  A 346 (-3.6A)
SAH  A 346 ( 3.7A)
SAH  A 346 (-3.6A)
SAH  A 346 (-3.4A)
None
None
 0.36A 1xdsA-3lstA:
16.3		 1xdsA-3lstA:
34.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		7 / 12 GLY A 189
GLY A 190
GLY A 191
ASP A 237
PHE A 238
ASN A 256
TRP A 257
 SAH  A 346 (-4.0A)
SAH  A 346 (-3.6A)
SAH  A 346 ( 3.7A)
SAH  A 346 (-3.6A)
SAH  A 346 (-3.4A)
None
None
 0.41A 1xdsB-3lstA:
24.5		 1xdsB-3lstA:
34.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		5 / 11 LEU A 173
GLY A 177
VAL A 185
ASP A 187
VAL A 247
 None
None
None
SAH  A 346 ( 4.5A)
None
 1.18A 2a1nA-3lstA:
undetectable		 2a1nA-3lstA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		5 / 10 LEU A 173
GLY A 177
VAL A 185
ASP A 187
VAL A 247
 None
None
None
SAH  A 346 ( 4.5A)
None
 1.16A 2cp4A-3lstA:
undetectable		 2cp4A-3lstA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		5 / 9 HIS A 248
VAL A 272
LEU A 280
ARG A 278
GLY A 342
 None
 1.50A 2xf3B-3lstA:
undetectable		 2xf3B-3lstA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		3 / 3 GLY A 191
ASP A 212
ASP A 237
 SAH  A 346 ( 3.7A)
SAH  A 346 (-3.0A)
SAH  A 346 (-3.6A)
 0.35A 3ou7C-3lstA:
11.3		 3ou7C-3lstA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_A_ADNA401_2
(ADENOSINE KINASE,
PUTATIVE)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		4 / 5 LEU A 144
ALA A 305
PHE A 118
ASN A 256
 None
 1.01A 3uq6A-3lstA:
undetectable		 3uq6A-3lstA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		4 / 4 LEU A 144
ALA A 305
PHE A 118
ASN A 256
 None
 1.11A 3vaqA-3lstA:
3.8		 3vaqA-3lstA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_A_ADNA401_2
(PUTATIVE ADENOSINE
KINASE)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		4 / 4 LEU A 144
ALA A 305
PHE A 118
ASN A 256
 None
 1.09A 3vasA-3lstA:
undetectable		 3vasA-3lstA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		5 / 12 GLY A 189
GLY A 191
VAL A 216
PHE A 238
TRP A 257
 SAH  A 346 (-4.0A)
SAH  A 346 ( 3.7A)
None
SAH  A 346 (-3.4A)
None
 0.75A 4a6eA-3lstA:
28.3		 4a6eA-3lstA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		5 / 12 ALA A 245
ASP A 187
ILE A 253
GLY A 236
ASP A 212
 None
SAH  A 346 ( 4.5A)
SAH  A 346 (-4.9A)
None
SAH  A 346 (-3.0A)
 1.49A 4iilA-3lstA:
2.9		 4iilA-3lstA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		5 / 12 VAL A 247
ILE A 339
GLY A 177
LEU A 206
LEU A 200
 None
 0.98A 4o1zA-3lstA:
undetectable		 4o1zA-3lstA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		8 / 11 SER A 166
GLY A 189
GLY A 190
ASP A 212
VAL A 216
ASP A 237
LYS A 251
ILE A 253
 SAH  A 346 (-2.9A)
SAH  A 346 (-4.0A)
SAH  A 346 (-3.6A)
SAH  A 346 (-3.0A)
None
SAH  A 346 (-3.6A)
SAH  A 346 (-2.7A)
SAH  A 346 (-4.9A)
 0.79A 4pghA-3lstA:
18.5		 4pghA-3lstA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		6 / 11 SER A 166
GLY A 191
ASP A 212
ASP A 237
LYS A 251
ILE A 253
 SAH  A 346 (-2.9A)
SAH  A 346 ( 3.7A)
SAH  A 346 (-3.0A)
SAH  A 346 (-3.6A)
SAH  A 346 (-2.7A)
SAH  A 346 (-4.9A)
 1.12A 4pghA-3lstA:
18.5		 4pghA-3lstA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		8 / 12 SER A 166
ASP A 187
GLY A 189
ASP A 212
ASP A 237
LYS A 251
ILE A 253
TRP A 257
 SAH  A 346 (-2.9A)
SAH  A 346 ( 4.5A)
SAH  A 346 (-4.0A)
SAH  A 346 (-3.0A)
SAH  A 346 (-3.6A)
SAH  A 346 (-2.7A)
SAH  A 346 (-4.9A)
None
 0.77A 4pghB-3lstA:
14.3		 4pghB-3lstA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		8 / 11 SER A 166
GLY A 189
ASP A 212
VAL A 216
ASP A 237
LYS A 251
ILE A 253
TRP A 257
 SAH  A 346 (-2.9A)
SAH  A 346 (-4.0A)
SAH  A 346 (-3.0A)
None
SAH  A 346 (-3.6A)
SAH  A 346 (-2.7A)
SAH  A 346 (-4.9A)
None
 0.88A 4pghC-3lstA:
30.0		 4pghC-3lstA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		5 / 12 GLY A 189
GLY A 190
ASP A 212
ASP A 237
LYS A 251
 SAH  A 346 (-4.0A)
SAH  A 346 (-3.6A)
SAH  A 346 (-3.0A)
SAH  A 346 (-3.6A)
SAH  A 346 (-2.7A)
 0.92A 4pghD-3lstA:
29.4		 4pghD-3lstA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		7 / 12 SER A 166
GLY A 189
GLY A 190
ASP A 212
LYS A 251
ILE A 253
TRP A 257
 SAH  A 346 (-2.9A)
SAH  A 346 (-4.0A)
SAH  A 346 (-3.6A)
SAH  A 346 (-3.0A)
SAH  A 346 (-2.7A)
SAH  A 346 (-4.9A)
None
 0.79A 4pghD-3lstA:
29.4		 4pghD-3lstA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		6 / 12 SER A 166
GLY A 191
ASP A 212
LYS A 251
ILE A 253
TRP A 257
 SAH  A 346 (-2.9A)
SAH  A 346 ( 3.7A)
SAH  A 346 (-3.0A)
SAH  A 346 (-2.7A)
SAH  A 346 (-4.9A)
None
 1.10A 4pghD-3lstA:
29.4		 4pghD-3lstA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		5 / 10 ALA A  45
THR A  64
LEU A  91
VAL A  82
LEU A  76
 None
 0.94A 4rz7A-3lstA:
undetectable		 4rz7A-3lstA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		4 / 6 THR A 307
SER A 143
LEU A 144
ASP A 145
 None
 1.01A 4wozA-3lstA:
undetectable
4wozB-3lstA:
undetectable		 4wozA-3lstA:
22.13
4wozB-3lstA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		6 / 12 GLY A 191
GLY A 194
LEU A 196
ALA A 214
ARG A 213
LEU A 211
 SAH  A 346 ( 3.7A)
None
None
None
SAH  A 346 (-3.4A)
None
 1.43A 5c0oG-3lstA:
10.0		 5c0oG-3lstA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		4 / 6 PHE A  89
LEU A  91
ARG A  88
GLY A  51
 None
 1.11A 5o4yF-3lstA:
undetectable		 5o4yF-3lstA:
4.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		5 / 12 GLY A 190
VAL A 216
PHE A 238
LEU A 239
TRP A 257
 SAH  A 346 (-3.6A)
None
SAH  A 346 (-3.4A)
SAH  A 346 ( 4.4A)
None
 0.47A 5w7pA-3lstA:
22.9		 5w7pA-3lstA:
25.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		5 / 12 GLY A 189
GLY A 191
ARG A 213
PHE A 238
TRP A 257
 SAH  A 346 (-4.0A)
SAH  A 346 ( 3.7A)
SAH  A 346 (-3.4A)
SAH  A 346 (-3.4A)
None
 0.50A 6clxA-3lstA:
19.2		 6clxA-3lstA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CLX_B_SAMB401_0
(O-METHYLTRANSFERASE)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		5 / 10 GLY A 190
ASP A 212
ARG A 213
PHE A 238
VAL A 249
 SAH  A 346 (-3.6A)
SAH  A 346 (-3.0A)
SAH  A 346 (-3.4A)
SAH  A 346 (-3.4A)
None
 1.30A 6clxB-3lstA:
18.4		 6clxB-3lstA:
35.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		6 / 11 GLY A 189
GLY A 191
ASP A 212
VAL A 216
ASP A 237
LYS A 251
 SAH  A 346 (-4.0A)
SAH  A 346 ( 3.7A)
SAH  A 346 (-3.0A)
None
SAH  A 346 (-3.6A)
SAH  A 346 (-2.7A)
 0.55A 6i5zD-3lstA:
29.7		 6i5zD-3lstA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		5 / 11 SER A 166
GLY A 189
GLY A 191
ASP A 212
LYS A 251
 SAH  A 346 (-2.9A)
SAH  A 346 (-4.0A)
SAH  A 346 ( 3.7A)
SAH  A 346 (-3.0A)
SAH  A 346 (-2.7A)
 1.02A 6i5zD-3lstA:
29.7		 6i5zD-3lstA:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3lst CALO1
METHYLTRANSFERASE
(Micromonospora
echinospora) 		5 / 12 ASP A 187
GLY A 189
GLY A 191
ASP A 237
PHE A 238
 SAH  A 346 ( 4.5A)
SAH  A 346 (-4.0A)
SAH  A 346 ( 3.7A)
SAH  A 346 (-3.6A)
SAH  A 346 (-3.4A)
 0.76A 6nj9K-3lstA:
7.4		 6nj9K-3lstA:
22.32