SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lsz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1S9P_B_DESB459_1 (ESTROGEN-RELATED RECEPTOR GAMMA)	3lsz	GLUTATHIONE S-TRANSFERASE (Rhodobacter sphaeroides)	5 / 12	LEU A 174 ALA A 175 LEU A 198 VAL A 194 PHE A 167	None	1.30A	1s9pB-3lszA: undetectable	1s9pB-3lszA: 24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1V8B_A_ADNA502_2 (ADENOSYLHOMOCYSTEINA SE)	3lsz	GLUTATHIONE S-TRANSFERASE (Rhodobacter sphaeroides)	3 / 3	GLU A 68 GLU A 27 LEU A 16	None	0.72A	1v8bA-3lszA: undetectable	1v8bA-3lszA: 16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OAX_D_SNLD4001_2 (MINERALOCORTICOID RECEPTOR)	3lsz	GLUTATHIONE S-TRANSFERASE (Rhodobacter sphaeroides)	4 / 5	LEU A 55 LEU A 47 CYH A 65 THR A 74	None None None TRS A 301 (-3.2A)	1.43A	2oaxD-3lszA: undetectable	2oaxD-3lszA: 19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VUF_A_FUAA2002_1 (SERUM ALBUMIN)	3lsz	GLUTATHIONE S-TRANSFERASE (Rhodobacter sphaeroides)	4 / 9	PHE A 108 ALA A 109 VAL A 113 GLU A 114	None None None GSH A 300 ( 4.7A)	0.60A	2vufA-3lszA: undetectable	2vufA-3lszA: 16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B9M_A_SALA1100_1 (SERUM ALBUMIN)	3lsz	GLUTATHIONE S-TRANSFERASE (Rhodobacter sphaeroides)	4 / 4	LEU A 149 ARG A 200 LEU A 198 ALA A 193	None	1.16A	3b9mA-3lszA: undetectable	3b9mA-3lszA: 16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P2K_A_SAMA6735_1 (16S RRNA METHYLASE)	3lsz	GLUTATHIONE S-TRANSFERASE (Rhodobacter sphaeroides)	3 / 3	ASP A 171 GLU A 98 SER A 203	None	0.82A	3p2kA-3lszA: undetectable	3p2kA-3lszA: 23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UNA_A_SALA1340_1 (XANTHINE DEHYDROGENASE/OXIDAS E)	3lsz	GLUTATHIONE S-TRANSFERASE (Rhodobacter sphaeroides)	5 / 9	LEU A 77 SER A 106 VAL A 169 LEU A 172 ALA A 175	None	1.27A	3unaA-3lszA: undetectable	3unaA-3lszA: 10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VLN_A_ASCA904_0 (GLUTATHIONE S-TRANSFERASE OMEGA-1)	3lsz	GLUTATHIONE S-TRANSFERASE (Rhodobacter sphaeroides)	4 / 6	ARG A 14 PRO A 64 GLU A 75 SER A 76	GSH A 300 ( 4.8A) GSH A 300 ( 4.6A) GSH A 300 (-3.1A) GSH A 300 (-2.7A)	0.68A	3vlnA-3lszA: 18.3	3vlnA-3lszA: 23.74

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1S9P_B_DESB459_1","ESTROGEN-RELATED RECEPTOR GAMMA","3lsz","GLUTATHIONE S-TRANSFERASE","Rhodobacter sphaeroides",5,"LEU A 174;ALA A 175;LEU A 198;VAL A 194;PHE A 167","None","1.30A","1s9pB-3lszA:undetectable","1s9pB-3lszA:24.38"],["1V8B_A_ADNA502_2","ADENOSYLHOMOCYSTEINASE","3lsz","GLUTATHIONE S-TRANSFERASE","Rhodobacter sphaeroides",3,"GLU A  68;GLU A  27;LEU A  16","None","0.72A","1v8bA-3lszA:undetectable","1v8bA-3lszA:16.77"],["2OAX_D_SNLD4001_2","MINERALOCORTICOID RECEPTOR","3lsz","GLUTATHIONE S-TRANSFERASE","Rhodobacter sphaeroides",4,"LEU A  55;LEU A  47;CYH A  65;THR A  74","None;None;None;TRS A 301 (-3.2A)","1.43A","2oaxD-3lszA:undetectable","2oaxD-3lszA:19.64"],["2VUF_A_FUAA2002_1","SERUM ALBUMIN","3lsz","GLUTATHIONE S-TRANSFERASE","Rhodobacter sphaeroides",4,"PHE A 108;ALA A 109;VAL A 113;GLU A 114","None;None;None;GSH A 300 ( 4.7A)","0.60A","2vufA-3lszA:undetectable","2vufA-3lszA:16.30"],["3B9M_A_SALA1100_1","SERUM ALBUMIN","3lsz","GLUTATHIONE S-TRANSFERASE","Rhodobacter sphaeroides",4,"LEU A 149;ARG A 200;LEU A 198;ALA A 193","None","1.16A","3b9mA-3lszA:undetectable","3b9mA-3lszA:16.30"],["3P2K_A_SAMA6735_1","16S RRNA METHYLASE","3lsz","GLUTATHIONE S-TRANSFERASE","Rhodobacter sphaeroides",3,"ASP A 171;GLU A  98;SER A 203","None","0.82A","3p2kA-3lszA:undetectable","3p2kA-3lszA:23.62"],["3UNA_A_SALA1340_1","XANTHINE DEHYDROGENASE\/OXIDASE","3lsz","GLUTATHIONE S-TRANSFERASE","Rhodobacter sphaeroides",5,"LEU A  77;SER A 106;VAL A 169;LEU A 172;ALA A 175","None","1.27A","3unaA-3lszA:undetectable","3unaA-3lszA:10.21"],["3VLN_A_ASCA904_0","GLUTATHIONE S-TRANSFERASE OMEGA-1","3lsz","GLUTATHIONE S-TRANSFERASE","Rhodobacter sphaeroides",4,"ARG A  14;PRO A  64;GLU A  75;SER A  76","GSH A 300 ( 4.8A);GSH A 300 ( 4.6A);GSH A 300 (-3.1A);GSH A 300 (-2.7A)","0.68A","3vlnA-3lszA:18.3","3vlnA-3lszA:23.74"]]