SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lt3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OKC_A_SAMA500_0 (TYPE I RESTRICTION ENZYME STYSJI M PROTEIN)	3lt3	POSSIBLE MEMBRANE-ASSOCIATED SERINE PROTEASE (Mycobacterium tuberculosis)	5 / 12	ILE A 207 GLY A 295 GLY A 222 THR A 305 VAL A 293	None	1.13A	2okcA-3lt3A: undetectable	2okcA-3lt3A: 19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LL3_A_017A202_2 (PROTEASE)	3lt3	POSSIBLE MEMBRANE-ASSOCIATED SERINE PROTEASE (Mycobacterium tuberculosis)	5 / 9	ALA A 285 ASP A 349 VAL A 291 GLY A 356 ILE A 309	None	1.07A	4ll3B-3lt3A: undetectable	4ll3B-3lt3A: 19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZJZ_A_BEZA1001_0 (BENZOATE-COENZYME A LIGASE)	3lt3	POSSIBLE MEMBRANE-ASSOCIATED SERINE PROTEASE (Mycobacterium tuberculosis)	5 / 8	VAL A 331 PHE A 359 GLY A 360 ALA A 361 GLY A 369	None	1.21A	4zjzA-3lt3A: undetectable	4zjzA-3lt3A: 18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B6I_A_ADNA302_1 (FLUORINASE)	3lt3	POSSIBLE MEMBRANE-ASSOCIATED SERINE PROTEASE (Mycobacterium tuberculosis)	4 / 7	THR A 303 TYR A 296 PRO A 297 THR A 221	None	1.35A	5b6iA-3lt3A: undetectable	5b6iA-3lt3A: 21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5I6X_A_8PRA705_1 (SODIUM-DEPENDENT SEROTONIN TRANSPORTER)	3lt3	POSSIBLE MEMBRANE-ASSOCIATED SERINE PROTEASE (Mycobacterium tuberculosis)	5 / 10	ALA A 307 ILE A 334 TYR A 332 GLY A 345 VAL A 338	None	1.24A	5i6xA-3lt3A: undetectable	5i6xA-3lt3A: 15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KPC_A_SAMA401_0 (PAVINE N-METHYLTRANSFERASE)	3lt3	POSSIBLE MEMBRANE-ASSOCIATED SERINE PROTEASE (Mycobacterium tuberculosis)	6 / 12	GLY A 222 GLY A 344 THR A 221 VAL A 245 THR A 244 ALA A 266	None	1.38A	5kpcA-3lt3A: undetectable	5kpcA-3lt3A: 18.80

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2OKC_A_SAMA500_0","TYPE I RESTRICTION ENZYME STYSJI M PROTEIN","3lt3","POSSIBLE MEMBRANE-ASSOCIATED SERINE PROTEASE","Mycobacterium tuberculosis",5,"ILE A 207;GLY A 295;GLY A 222;THR A 305;VAL A 293","None","1.13A","2okcA-3lt3A:undetectable","2okcA-3lt3A:19.24"],["4LL3_A_017A202_2","PROTEASE;PROTEASE","3lt3","POSSIBLE MEMBRANE-ASSOCIATED SERINE PROTEASE","Mycobacterium tuberculosis",5,"ALA A 285;ASP A 349;VAL A 291;GLY A 356;ILE A 309","None","1.07A","4ll3B-3lt3A:undetectable","4ll3B-3lt3A:19.14"],["4ZJZ_A_BEZA1001_0","BENZOATE-COENZYME A LIGASE","3lt3","POSSIBLE MEMBRANE-ASSOCIATED SERINE PROTEASE","Mycobacterium tuberculosis",5,"VAL A 331;PHE A 359;GLY A 360;ALA A 361;GLY A 369","None","1.21A","4zjzA-3lt3A:undetectable","4zjzA-3lt3A:18.86"],["5B6I_A_ADNA302_1","FLUORINASE","3lt3","POSSIBLE MEMBRANE-ASSOCIATED SERINE PROTEASE","Mycobacterium tuberculosis",4,"THR A 303;TYR A 296;PRO A 297;THR A 221","None","1.35A","5b6iA-3lt3A:undetectable","5b6iA-3lt3A:21.67"],["5I6X_A_8PRA705_1","SODIUM-DEPENDENT SEROTONIN TRANSPORTER","3lt3","POSSIBLE MEMBRANE-ASSOCIATED SERINE PROTEASE","Mycobacterium tuberculosis",5,"ALA A 307;ILE A 334;TYR A 332;GLY A 345;VAL A 338","None","1.24A","5i6xA-3lt3A:undetectable","5i6xA-3lt3A:15.89"],["5KPC_A_SAMA401_0","PAVINE N-METHYLTRANSFERASE","3lt3","POSSIBLE MEMBRANE-ASSOCIATED SERINE PROTEASE","Mycobacterium tuberculosis",6,"GLY A 222;GLY A 344;THR A 221;VAL A 245;THR A 244;ALA A 266","None","1.38A","5kpcA-3lt3A:undetectable","5kpcA-3lt3A:18.80"]]