SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3lti'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DG4_A_RAPA501_1 (FK506-BINDING PROTEIN 1A)	3lti	DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA (Escherichia coli)	5 / 11	TYR A 291 GLU A 240 ILE A 285 ILE A 269 PHE A 253	MLY A 295 ( 4.5A) None None None None	1.24A	2dg4A-3ltiA: undetectable	2dg4A-3ltiA: 16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q72_A_IXXA801_1 (TRANSPORTER)	3lti	DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA (Escherichia coli)	5 / 11	LEU A 210 ILE A 425 PHE A 385 ALA A 206 LEU A 184	None MLY A 422 ( 4.1A) None None None	1.11A	2q72A-3ltiA: undetectable	2q72A-3ltiA: 18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Q72_A_IXXA801_1 (TRANSPORTER)	3lti	DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA (Escherichia coli)	5 / 11	LEU A 213 LEU A 210 ILE A 425 ALA A 206 LEU A 184	MLY A 422 ( 4.1A) None MLY A 422 ( 4.1A) None None	1.08A	2q72A-3ltiA: undetectable	2q72A-3ltiA: 18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QB4_A_DSMA801_1 (TRANSPORTER)	3lti	DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA (Escherichia coli)	5 / 12	LEU A 210 ILE A 425 PHE A 385 ALA A 206 LEU A 184	None MLY A 422 ( 4.1A) None None None	1.09A	2qb4A-3ltiA: undetectable	2qb4A-3ltiA: 18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QB4_A_DSMA801_1 (TRANSPORTER)	3lti	DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA (Escherichia coli)	5 / 12	LEU A 213 LEU A 210 ILE A 425 ALA A 206 LEU A 184	MLY A 422 ( 4.1A) None MLY A 422 ( 4.1A) None None	1.06A	2qb4A-3ltiA: undetectable	2qb4A-3ltiA: 18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QJU_A_DSMA801_1 (TRANSPORTER)	3lti	DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA (Escherichia coli)	5 / 11	LEU A 210 ILE A 425 PHE A 385 ALA A 206 LEU A 184	None MLY A 422 ( 4.1A) None None None	1.13A	2qjuA-3ltiA: undetectable	2qjuA-3ltiA: 18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QJU_A_DSMA801_1 (TRANSPORTER)	3lti	DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA (Escherichia coli)	5 / 11	LEU A 213 LEU A 210 ILE A 425 ALA A 206 LEU A 184	MLY A 422 ( 4.1A) None MLY A 422 ( 4.1A) None None	1.06A	2qjuA-3ltiA: undetectable	2qjuA-3ltiA: 18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GWV_A_RFXA801_1 (TRANSPORTER)	3lti	DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA (Escherichia coli)	5 / 12	LEU A 213 LEU A 210 ILE A 425 ALA A 206 LEU A 184	MLY A 422 ( 4.1A) None MLY A 422 ( 4.1A) None None	1.05A	3gwvA-3ltiA: undetectable	3gwvA-3ltiA: 18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ODR_A_FK5A201_1 (PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1A CHIMERA)	3lti	DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA (Escherichia coli)	6 / 12	ASP A 427 LEU A 223 LEU A 210 ILE A 209 LEU A 213 ILE A 176	None MLY A 430 ( 4.4A) None None MLY A 422 ( 4.1A) None	1.38A	4odrA-3ltiA: undetectable 4odrB-3ltiA: undetectable	4odrA-3ltiA: 16.04 4odrB-3ltiA: 16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QT3_A_RAPA202_1 (FK506-BINDING PROTEIN (FKBP)-TYPE PEPTIDYL-PROPYL ISOMERASE)	3lti	DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA (Escherichia coli)	5 / 10	TYR A 291 GLU A 240 ILE A 285 ILE A 269 PHE A 253	MLY A 295 ( 4.5A) None None None None	1.25A	4qt3A-3ltiA: undetectable	4qt3A-3ltiA: 17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EKU_A_ZMRA901_2 (SIALIDASE)	3lti	DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA (Escherichia coli)	4 / 6	ASP A 427 ASN A 406 LEU A 397 SER A 417	None	1.12A	6ekuA-3ltiA: undetectable	6ekuA-3ltiA: 18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MKE_D_FK5D201_1 (PEPTIDYLPROLYL ISOMERASE)	3lti	DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA (Escherichia coli)	5 / 10	TYR A 291 PHE A 230 ILE A 285 ILE A 269 PHE A 253	MLY A 295 ( 4.5A) None None None None	1.46A	6mkeD-3ltiA: undetectable	6mkeD-3ltiA: 13.11

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2DG4_A_RAPA501_1","FK506-BINDING PROTEIN 1A","3lti","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","Escherichia coli",5,"TYR A 291;GLU A 240;ILE A 285;ILE A 269;PHE A 253","MLY A 295 ( 4.5A);None;None;None;None","1.24A","2dg4A-3ltiA:undetectable","2dg4A-3ltiA:16.16"],["2Q72_A_IXXA801_1","TRANSPORTER","3lti","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","Escherichia coli",5,"LEU A 210;ILE A 425;PHE A 385;ALA A 206;LEU A 184","None;MLY A 422 ( 4.1A);None;None;None","1.11A","2q72A-3ltiA:undetectable","2q72A-3ltiA:18.43"],["2Q72_A_IXXA801_1","TRANSPORTER","3lti","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","Escherichia coli",5,"LEU A 213;LEU A 210;ILE A 425;ALA A 206;LEU A 184","MLY A 422 ( 4.1A);None;MLY A 422 ( 4.1A);None;None","1.08A","2q72A-3ltiA:undetectable","2q72A-3ltiA:18.43"],["2QB4_A_DSMA801_1","TRANSPORTER","3lti","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","Escherichia coli",5,"LEU A 210;ILE A 425;PHE A 385;ALA A 206;LEU A 184","None;MLY A 422 ( 4.1A);None;None;None","1.09A","2qb4A-3ltiA:undetectable","2qb4A-3ltiA:18.43"],["2QB4_A_DSMA801_1","TRANSPORTER","3lti","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","Escherichia coli",5,"LEU A 213;LEU A 210;ILE A 425;ALA A 206;LEU A 184","MLY A 422 ( 4.1A);None;MLY A 422 ( 4.1A);None;None","1.06A","2qb4A-3ltiA:undetectable","2qb4A-3ltiA:18.43"],["2QJU_A_DSMA801_1","TRANSPORTER","3lti","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","Escherichia coli",5,"LEU A 210;ILE A 425;PHE A 385;ALA A 206;LEU A 184","None;MLY A 422 ( 4.1A);None;None;None","1.13A","2qjuA-3ltiA:undetectable","2qjuA-3ltiA:18.52"],["2QJU_A_DSMA801_1","TRANSPORTER","3lti","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","Escherichia coli",5,"LEU A 213;LEU A 210;ILE A 425;ALA A 206;LEU A 184","MLY A 422 ( 4.1A);None;MLY A 422 ( 4.1A);None;None","1.06A","2qjuA-3ltiA:undetectable","2qjuA-3ltiA:18.52"],["3GWV_A_RFXA801_1","TRANSPORTER","3lti","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","Escherichia coli",5,"LEU A 213;LEU A 210;ILE A 425;ALA A 206;LEU A 184","MLY A 422 ( 4.1A);None;MLY A 422 ( 4.1A);None;None","1.05A","3gwvA-3ltiA:undetectable","3gwvA-3ltiA:18.38"],["4ODR_A_FK5A201_1","PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1A CHIMERA;PEPTIDYL-PROLYL CIS-TRANS ISOMERASE SLYD, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP1A CHIMERA","3lti","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","Escherichia coli",6,"ASP A 427;LEU A 223;LEU A 210;ILE A 209;LEU A 213;ILE A 176","None;MLY A 430 ( 4.4A);None;None;MLY A 422 ( 4.1A);None","1.38A","4odrA-3ltiA:undetectable;4odrB-3ltiA:undetectable","4odrA-3ltiA:16.04;4odrB-3ltiA:16.04"],["4QT3_A_RAPA202_1","FK506-BINDING PROTEIN (FKBP)-TYPE PEPTIDYL-PROPYL ISOMERASE","3lti","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","Escherichia coli",5,"TYR A 291;GLU A 240;ILE A 285;ILE A 269;PHE A 253","MLY A 295 ( 4.5A);None;None;None;None","1.25A","4qt3A-3ltiA:undetectable","4qt3A-3ltiA:17.23"],["6EKU_A_ZMRA901_2","SIALIDASE","3lti","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","Escherichia coli",4,"ASP A 427;ASN A 406;LEU A 397;SER A 417","None","1.12A","6ekuA-3ltiA:undetectable","6ekuA-3ltiA:18.29"],["6MKE_D_FK5D201_1","PEPTIDYLPROLYL ISOMERASE","3lti","DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA","Escherichia coli",5,"TYR A 291;PHE A 230;ILE A 285;ILE A 269;PHE A 253","MLY A 295 ( 4.5A);None;None;None;None","1.46A","6mkeD-3ltiA:undetectable","6mkeD-3ltiA:13.11"]]