SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ltj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 3ltj ALPHAREP-4
(synthetic
construct) 		5 / 11 ALA A  73
ILE A  77
GLY A  47
LEU A  55
ALA A  51
 None
 1.17A 3kw2A-3ltjA:
undetectable		 3kw2A-3ltjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 3ltj ALPHAREP-4
(synthetic
construct) 		5 / 11 ALA A 104
ILE A 108
GLY A  78
LEU A  86
ALA A  82
 None
 1.22A 3kw2A-3ltjA:
undetectable		 3kw2A-3ltjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 3ltj ALPHAREP-4
(synthetic
construct) 		5 / 11 ALA A 135
ILE A 139
GLY A 109
LEU A 117
ALA A 113
 None
 1.20A 3kw2A-3ltjA:
undetectable		 3kw2A-3ltjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 3ltj ALPHAREP-4
(synthetic
construct) 		5 / 11 ALA A 166
ILE A 170
GLY A 140
LEU A 148
ALA A 144
 None
 1.17A 3kw2A-3ltjA:
undetectable		 3kw2A-3ltjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 3ltj ALPHAREP-4
(synthetic
construct) 		5 / 11 ALA A  73
ILE A  77
GLY A  47
LEU A  55
ALA A  51
 None
 1.19A 3kw2B-3ltjA:
undetectable		 3kw2B-3ltjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 3ltj ALPHAREP-4
(synthetic
construct) 		5 / 11 ALA A 104
ILE A 108
GLY A  78
LEU A  86
ALA A  82
 None
 1.24A 3kw2B-3ltjA:
undetectable		 3kw2B-3ltjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 3ltj ALPHAREP-4
(synthetic
construct) 		5 / 11 ALA A 135
ILE A 139
GLY A 109
LEU A 117
ALA A 113
 None
 1.22A 3kw2B-3ltjA:
undetectable		 3kw2B-3ltjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 3ltj ALPHAREP-4
(synthetic
construct) 		5 / 11 ALA A 166
ILE A 170
GLY A 140
LEU A 148
ALA A 144
 None
 1.18A 3kw2B-3ltjA:
undetectable		 3kw2B-3ltjA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 3ltj ALPHAREP-4
(synthetic
construct) 		5 / 12 GLY A  44
GLY A  47
VAL A  52
ALA A  70
ALA A  69
 None
 0.98A 3mteA-3ltjA:
undetectable		 3mteA-3ltjA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 3ltj ALPHAREP-4
(synthetic
construct) 		5 / 12 GLY A 106
GLY A 109
VAL A 114
ALA A 132
ALA A 131
 None
 0.99A 3mteA-3ltjA:
undetectable		 3mteA-3ltjA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 3ltj ALPHAREP-4
(synthetic
construct) 		5 / 12 GLY A  44
GLY A  47
VAL A  52
ALA A  70
ALA A  69
 None
 1.01A 3mteB-3ltjA:
undetectable		 3mteB-3ltjA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 3ltj ALPHAREP-4
(synthetic
construct) 		5 / 12 GLY A 106
GLY A 109
VAL A 114
ALA A 132
ALA A 131
 None
 1.03A 3mteB-3ltjA:
undetectable		 3mteB-3ltjA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 3ltj ALPHAREP-4
(synthetic
construct) 		5 / 12 GLY A  44
GLY A  47
VAL A  52
ALA A  70
ALA A  69
 None
 1.09A 3p2kC-3ltjA:
undetectable		 3p2kC-3ltjA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 3ltj ALPHAREP-4
(synthetic
construct) 		5 / 12 GLY A  44
GLY A  47
VAL A  52
ALA A  70
ALA A  69
 None
 0.98A 3p2kD-3ltjA:
undetectable		 3p2kD-3ltjA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 3ltj ALPHAREP-4
(synthetic
construct) 		5 / 12 GLY A 106
GLY A 109
VAL A 114
ALA A 132
ALA A 131
 None
 0.98A 3p2kD-3ltjA:
undetectable		 3p2kD-3ltjA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 3ltj ALPHAREP-4
(synthetic
construct) 		3 / 3 ALA A 135
GLN A  76
GLY A  44
 None
 0.62A 4odoC-3ltjA:
undetectable		 4odoC-3ltjA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3ltj ALPHAREP-4
(synthetic
construct) 		4 / 8 LEU A  59
GLU A  84
LEU A 105
ILE A 108
 None
 0.96A 5mzjA-3ltjA:
undetectable		 5mzjA-3ltjA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA602_0
(THIOCYANATE
DEHYDROGENASE)		 3ltj ALPHAREP-4
(synthetic
construct) 		3 / 3 LYS A  12
HIS A  12
HIS A  14
 None
 1.07A 5oexA-3ltjA:
undetectable		 5oexA-3ltjA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB602_0
(THIOCYANATE
DEHYDROGENASE)		 3ltj ALPHAREP-4
(synthetic
construct) 		3 / 3 LYS A  12
HIS A  12
HIS A  14
 None
 1.08A 5oexB-3ltjA:
undetectable		 5oexB-3ltjA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC603_0
(THIOCYANATE
DEHYDROGENASE)		 3ltj ALPHAREP-4
(synthetic
construct) 		3 / 3 LYS A  12
HIS A  12
HIS A  14
 None
 1.08A 5oexC-3ltjA:
undetectable		 5oexC-3ltjA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 3ltj ALPHAREP-4
(synthetic
construct) 		3 / 3 LYS A  12
HIS A  12
HIS A  14
 None
 1.09A 5oexD-3ltjA:
undetectable		 5oexD-3ltjA:
19.70