SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ltl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3ltl BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A 777
ALA A 805
ALA A 828
LEU A 870
TYR A 852
 None
 1.14A 1cbrA-3ltlA:
undetectable		 1cbrA-3ltlA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3ltl BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A 777
ALA A 805
ALA A 828
LEU A 870
TYR A 852
 None
 1.13A 1cbrB-3ltlA:
undetectable		 1cbrB-3ltlA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 3ltl BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A 777
ALA A 805
ALA A 828
LEU A 870
TYR A 852
 None
 1.07A 1cbsA-3ltlA:
undetectable		 1cbsA-3ltlA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 3ltl BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1
(Homo
sapiens) 		4 / 6 PRO A 713
ASP A 754
ASN A 755
ASP A 756
 None
 1.42A 1hpkA-3ltlA:
undetectable		 1hpkA-3ltlA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 3ltl BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1
(Homo
sapiens) 		5 / 12 HIS A 770
MET A 801
LEU A 781
PHE A 788
ILE A 832
 CA  A   2 (-4.0A)
None
None
None
None
 1.16A 1xosA-3ltlA:
undetectable		 1xosA-3ltlA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 3ltl BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1
(Homo
sapiens) 		4 / 5 LEU A 743
ILE A 717
ILE A 733
ALA A 734
 None
 0.77A 2i2zA-3ltlA:
2.9		 2i2zA-3ltlA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 3ltl BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1
(Homo
sapiens) 		5 / 10 LEU A 781
LEU A 834
MET A 833
MET A 801
LEU A 827
 None
 1.21A 2ocfA-3ltlA:
undetectable		 2ocfA-3ltlA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3ltl BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1
(Homo
sapiens) 		5 / 12 ASN A 856
LEU A 865
ILE A 873
TYR A 808
THR A 816
 None
 1.02A 3fl9B-3ltlA:
undetectable		 3fl9B-3ltlA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3ltl BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1
(Homo
sapiens) 		5 / 12 ASN A 856
LEU A 865
ILE A 873
TYR A 808
THR A 816
 None
 1.11A 3fl9G-3ltlA:
undetectable		 3fl9G-3ltlA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3ltl BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 865
PHE A 818
ALA A 828
ALA A 780
VAL A 778
 None
 1.03A 4nkxC-3ltlA:
undetectable		 4nkxC-3ltlA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3ltl BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 865
PHE A 818
ALA A 828
ALA A 780
VAL A 778
 None
 0.99A 4nkxD-3ltlA:
undetectable		 4nkxD-3ltlA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3ltl BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1
(Homo
sapiens) 		4 / 4 ILE A 831
ILE A 882
ARG A 782
LEU A 834
 None
 1.14A 5dzkh-3ltlA:
undetectable
5dzkn-3ltlA:
undetectable
5dzkv-3ltlA:
undetectable		 5dzkh-3ltlA:
19.73
5dzkn-3ltlA:
19.73
5dzkv-3ltlA:
1.98