SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ltm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 3ltm ALPHA-REP4
(synthetic
construct) 		5 / 9 ALA A  40
TYR A  24
ALA A  16
GLY A  44
ILE A  46
 None
 1.33A 2v7bB-3ltmA:
undetectable		 2v7bB-3ltmA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 3ltm ALPHA-REP4
(synthetic
construct) 		5 / 11 ALA A 135
ILE A 139
GLY A 109
LEU A 117
ALA A 113
 None
 1.22A 3kw2A-3ltmA:
undetectable		 3kw2A-3ltmA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 3ltm ALPHA-REP4
(synthetic
construct) 		5 / 11 ALA A 135
ILE A 139
GLY A 109
LEU A 117
ALA A 113
 None
 1.24A 3kw2B-3ltmA:
undetectable		 3kw2B-3ltmA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 3ltm ALPHA-REP4
(synthetic
construct) 		5 / 12 GLY A  44
GLY A  47
VAL A  52
ALA A  70
ALA A  69
 None
None
None
None
12P  A1002 (-3.8A)
 1.06A 3mteA-3ltmA:
undetectable		 3mteA-3ltmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 3ltm ALPHA-REP4
(synthetic
construct) 		5 / 12 GLY A 106
GLY A 109
VAL A 114
ALA A 132
ALA A 131
 None
None
None
None
1PE  A1001 (-3.3A)
 0.99A 3mteA-3ltmA:
undetectable		 3mteA-3ltmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 3ltm ALPHA-REP4
(synthetic
construct) 		5 / 12 GLY A 106
GLY A 109
VAL A 114
ALA A 132
ALA A 131
 None
None
None
None
1PE  A1001 (-3.3A)
 1.03A 3mteB-3ltmA:
undetectable		 3mteB-3ltmA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 3ltm ALPHA-REP4
(synthetic
construct) 		5 / 12 GLY A  44
GLY A  47
VAL A  52
ALA A  70
ALA A  69
 None
None
None
None
12P  A1002 (-3.8A)
 1.03A 3p2kD-3ltmA:
undetectable		 3p2kD-3ltmA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 3ltm ALPHA-REP4
(synthetic
construct) 		5 / 12 GLY A 106
GLY A 109
VAL A 114
ALA A 132
ALA A 131
 None
None
None
None
1PE  A1001 (-3.3A)
 0.99A 3p2kD-3ltmA:
undetectable		 3p2kD-3ltmA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3ltm ALPHA-REP4
(synthetic
construct) 		5 / 12 GLU A  80
LEU A  86
GLY A  78
LEU A  55
ALA A  70
 None
 1.25A 5kbwA-3ltmA:
undetectable		 5kbwA-3ltmA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 3ltm ALPHA-REP4
(synthetic
construct) 		5 / 12 GLU A  80
LEU A  86
GLY A  78
LEU A  55
ALA A  70
 None
 1.23A 5kc4E-3ltmA:
undetectable		 5kc4E-3ltmA:
21.33